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International Journal of Colorectal Disease

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01-07-2020 | Anemia | Original Article

Impacts of anemia and transfusion on oncologic outcomes in patients undergoing surgery for colorectal cancer

Authors: Yoon-Hye Kwon, Han-Ki Lim, Min Jung Kim, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park

Published in: International Journal of Colorectal Disease | Issue 7/2020

Abstract

Purpose

This study aimed to evaluate the prevalence of preoperative anemia and impacts of anemia and transfusion on survival in patients undergoing surgery for colorectal cancer.

Methods

This study included patients who underwent surgery for primary colorectal cancer between 2011 and 2012. The influence of preoperative anemia and postoperative transfusion on recurrence-free survival and overall survival were retrospectively investigated. Anemia was defined as hemoglobin level < 13 g/dL in males and < 12 g/dL in females. The primary outcome was the prevalence of preoperative anemia in patients with colorectal cancer. Secondary outcomes included preoperative anemia management, postoperative 30-day mortality and morbidity, tumor recurrence, and overall survival.

Results

Among a total of 1899 patients, 823 patients (43.3%) were anemic preoperatively, and 264 patients (13.9%) received postoperative transfusions. Postoperative transfusion was associated with 30-day postoperative complications (OR = 1.514, 95% CI = 1.020 ~ 2.247) but not preoperative anemia (OR = 1.143, 95% CI, 0.811 ~ 1.611). Preoperative anemia (HR = 1.459, 95% CI = 1.104 ~ 1.929) and postoperative transfusion (HR = 1.566, 95% CI = 1.089 ~ 2.252) were significantly associated with worse recurrence-free survival in multivariable analysis. Preoperative anemia (HR = 1.572, 95% CI = 1.274 ~ 1.940) and postoperative transfusion (HR = 1.381, 95% CI = 1.076 ~ 1.773) were significant independent risk factors for worse overall survival.

Conclusions

Preoperative anemia and postoperative transfusion were associated with worse survival in patients undergoing surgery for colorectal cancer. An alternative therapy to treat anemia and reduce transfusions should be introduced to improve oncologic outcomes.

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Title: Impacts of anemia and transfusion on oncologic outcomes in patients undergoing surgery for colorectal cancer
Authors: Yoon-Hye Kwon
Han-Ki Lim
Min Jung Kim
Ji Won Park
Seung-Bum Ryoo
Seung-Yong Jeong
Kyu Joo Park
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Keywords: Anemia
Colorectal Cancer
Colorectal Cancer
Published in: International Journal of Colorectal Disease / Issue 7/2020
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-020-03601-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Impacts of anemia and transfusion on oncologic outcomes in patients undergoing surgery for colorectal cancer

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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