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International Journal of Colorectal Disease

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Open Access 01-10-2019 | Constipation | Short Communication

Normal colonic transit time predicts the outcome of colonic manometry in patients with chronic constipation—an exploratory study

Authors: Lisa Vork, Mark H. P. van Avesaat, Eduard A. van Hoboken, Joanna W. Kruimel, Jose M. Conchillo, Daniel Keszthelyi, Ad A. M. Masclee

Published in: International Journal of Colorectal Disease | Issue 10/2019

Abstract

Purpose

Colonic manometry (CM) can be of additive value in the diagnostic workup of colonic motility in chronic constipated patients. However, it is claimed that colonic motor disturbances occur in normal-transit constipation (NTC) and slow-transit (STC) constipation, as measured using a radio-opaque marker study, and therefore, the relationship between colonic motor disturbances on CM and colonic transit time (CTT) remains unclear. Our aim was to compare results from colonic marker study with the outcome of CM in patients with treatment-refractory chronic constipation (CC).

Method

Eighty-seven CC patients and 12 healthy volunteers, undergoing both a CTT study and a 24-h CM in a Dutch tertiary referral center, were included. CTT was measured using radio-opaque markers (X-ray at day 4 after ingestion of 20 markers at day 0). CM was performed using a catheter with 6 solid-state pressure sensors, endoscopically clipped to the mucosa in the right colon. CM was defined as normal when at least three high-amplitude propagating contractions (HAPCs), i.e., propagating waves with amplitude ≥ 80 mmHg over at least three sensors, were identified.

Results

In total, 70 patients showed STC on CTT, of which 21 (30%) showed normal CM. All 17 NTC patients and healthy volunteers showed normal CM. The negative predictive value of CTT for normal CM was 100%.

Conclusion

Colonic manometry should be considered in therapy-refractory STC patients in order to further delineate colonic motility. However, in this exploratory study, for patients presenting with NTC on a radio-opaque marker study, colonic manometry does not appear to have added value.

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Title: Normal colonic transit time predicts the outcome of colonic manometry in patients with chronic constipation—an exploratory study
Authors: Lisa Vork
Mark H. P. van Avesaat
Eduard A. van Hoboken
Joanna W. Kruimel
Jose M. Conchillo
Daniel Keszthelyi
Ad A. M. Masclee
Publication date: 01-10-2019
Publisher: Springer Berlin Heidelberg
Keywords: Constipation
Constipation
Published in: International Journal of Colorectal Disease / Issue 10/2019
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-019-03376-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Normal colonic transit time predicts the outcome of colonic manometry in patients with chronic constipation—an exploratory study

Abstract

Purpose

Method

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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