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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 8/2019

01-08-2019 | Familial Adenomatous Polyposis | Original Article

Common habitual behaviors and synchronous colorectal cancer risk: a retrospective case-control study

Authors: Yi-Hung Kuo, Hsin-Yuan Hung, Jeng-Fu You, Jy-Ming Chiang, Chih-Chien Chin

Published in: International Journal of Colorectal Disease | Issue 8/2019

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Abstract

Purpose

The association of habitual behaviors with the prevalence of synchronous colorectal cancer (sCRC) is unknown. Here, we investigated whether these behaviors, which are known risk factors for colorectal polyps, may be related to sCRC risk.

Methods

We enrolled 17,093 patients who underwent cancer treatment between January 1995 and December 2016 and examined the association of age, sex, familial history of hereditary colorectal cancer (CRC), and status of three common habitual behaviors (smoking and alcohol and coffee consumption) with the prevalence of sCRC.

Results

Of the enrolled patients, 960 (5.6%) patients had sCRC. The independent risk factors for sCRC prevalence included advanced age, male sex, hereditary CRC, smoking, and daily alcohol consumption of more than one bottle (> 600 mL). Contrary to these factors, daily coffee consumption of more than one cup seemed to provide a protection from sCRC. In the Kaplan-Meier test, the significantly worse 5-year overall survival (OS) was noted in smokers with stage 0–III CRC. The effect of alcohol consumption on 5-year OS was significant in stages II and III. Compared with those without daily coffee consumption, patients with daily coffee consumption had significantly higher 5-year OS in stages I (93.0% vs. 86.4%), II (87.1% vs. 77.2%), III (71.5% vs. 61.9%), and IV (18.0% vs. 13.0%).

Conclusions

sCRC prevalence was significantly associated with habitual behaviors. Patients with smoking or with daily alcohol consumption of one bottle had higher sCRC prevalence than did those without these habits. Coffee consumption could be a protective factor for lowering sCRC risk.
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Metadata
Title
Common habitual behaviors and synchronous colorectal cancer risk: a retrospective case-control study
Authors
Yi-Hung Kuo
Hsin-Yuan Hung
Jeng-Fu You
Jy-Ming Chiang
Chih-Chien Chin
Publication date
01-08-2019
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 8/2019
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-019-03326-x

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