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Published in: International Journal of Colorectal Disease 1/2019

01-01-2019 | Original Article

Preoperative anatomical road mapping reduces variability of operating time, estimated blood loss, and lymph node yield in right colectomy with extended D3 mesenterectomy for cancer

Authors: Christer-Daniel Willard, Erik Kjaestad, Bojan V. Stimec, Bjorn Edwin, Dejan Ignjatovic, RCC Study Group

Published in: International Journal of Colorectal Disease | Issue 1/2019

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Abstract

Objective

To assess the impact of individual patient anatomy on operating time, estimated blood loss (EBL), and lymph node yield in right colectomy with extended D3 mesenterectomy, where surgeons have access to a preoperative 3-D reconstruction of the vascular anatomy of patients before surgery.

Aim/summary background data

Data on the impact of individual patient vascular anatomy when surgeons have an anatomical road map as a guide at surgery is still missing in the literature.

Method

Consecutive patients enrolled in an ongoing trial were classified into 4 groups and 2 subgroups using a 3-D vascular anatomy reconstruction derived from the staging CT. Outcome measures are operating time, EBL, vascular events, and D3 volume lymph node yield. SPSS was used for statistical analysis.

Results

One hundred seventy-six (77 men) patients included. Mean operating time was 200 ± 50 min. Type 4b required significantly longer operating time (mean, 219 ± 59) compared to type 3 (mean, 188 ± 43) (p = 0.004). Vascular events occurred most often in anatomy type 4b (20.0%) and 3 (19.2%). No difference in EBL and lymph node yield was found (p = 0.102 and p = 0.803, respectively).

Conclusion

The use of a roadmap at surgery seems to even differences in operating time, EBL, and lymph node yield, independent of the complexity of the individual patient’s central mesenteric vascular anatomy. The incidents of vascular events requiring hemostasis do not cause differences in EBL between the anatomy groups, suggesting that preoperative awareness of the anatomy is beneficial at surgery.
Literature
1.
go back to reference Miyamoto R, Tadano S, Sano N, Inagawa S, Adachi S, Yamamoto M (2017) The impact of three-dimensional reconstruction on laparoscopic-assisted surgery for right-sided colon cancer. Wideochir Inne Tech Maloinwazyjne 12(3):251–256PubMedPubMedCentral Miyamoto R, Tadano S, Sano N, Inagawa S, Adachi S, Yamamoto M (2017) The impact of three-dimensional reconstruction on laparoscopic-assisted surgery for right-sided colon cancer. Wideochir Inne Tech Maloinwazyjne 12(3):251–256PubMedPubMedCentral
2.
go back to reference Hohenberger W, Weber K, Matzel K, Papadopoulos T, Merkel S (2009) Standardized surgery for colonic cancer: complete mesocolic excision and central ligation--technical notes and outcome. Colorectal Dis 11(4):354–364 discussion 64-5CrossRef Hohenberger W, Weber K, Matzel K, Papadopoulos T, Merkel S (2009) Standardized surgery for colonic cancer: complete mesocolic excision and central ligation--technical notes and outcome. Colorectal Dis 11(4):354–364 discussion 64-5CrossRef
3.
go back to reference West NP, Hohenberger W, Weber K, Perrakis A, Finan PJ, Quirke P (2010) Complete mesocolic excision with central vascular ligation produces an oncologically superior specimen compared with standard surgery for carcinoma of the colon. J Clin Oncol Off J Am Soc Clin Oncol 28(2):272–278CrossRef West NP, Hohenberger W, Weber K, Perrakis A, Finan PJ, Quirke P (2010) Complete mesocolic excision with central vascular ligation produces an oncologically superior specimen compared with standard surgery for carcinoma of the colon. J Clin Oncol Off J Am Soc Clin Oncol 28(2):272–278CrossRef
4.
go back to reference Nesgaard JM, Stimec BV, Bakka AO, Edwin B, Ignjatovic D (2017) Navigating the mesentery: part II. Vascular abnormalities and a review of the literature. Colorectal Dis 19(7):656–666CrossRefPubMed Nesgaard JM, Stimec BV, Bakka AO, Edwin B, Ignjatovic D (2017) Navigating the mesentery: part II. Vascular abnormalities and a review of the literature. Colorectal Dis 19(7):656–666CrossRefPubMed
5.
go back to reference Nesgaard JM, Stimec BV, Bakka AO, Edwin B, Ignjatovic D (2015) Navigating the mesentery: a comparative pre- and per-operative visualization of the vascular anatomy. Colorectal Dis 17(9):810–818CrossRefPubMed Nesgaard JM, Stimec BV, Bakka AO, Edwin B, Ignjatovic D (2015) Navigating the mesentery: a comparative pre- and per-operative visualization of the vascular anatomy. Colorectal Dis 17(9):810–818CrossRefPubMed
6.
go back to reference Mari FS, Nigri G, Pancaldi A, De Cecco CN, Gasparrini M, Dall’Oglio A et al (2013) Role of CT angiography with three-dimensional reconstruction of mesenteric vessels in laparoscopic colorectal resections: a randomized controlled trial. Surg Endosc 27(6):2058–2067CrossRefPubMed Mari FS, Nigri G, Pancaldi A, De Cecco CN, Gasparrini M, Dall’Oglio A et al (2013) Role of CT angiography with three-dimensional reconstruction of mesenteric vessels in laparoscopic colorectal resections: a randomized controlled trial. Surg Endosc 27(6):2058–2067CrossRefPubMed
7.
go back to reference Wang JB, Huang CM, Zheng CH, Li P, Xie JW, Lin JX, Lu J (2014) Role of 3DCT in laparoscopic total gastrectomy with spleen-preserving splenic lymph node dissection. World J Gastroenterol 20(16):4797–4805CrossRefPubMedPubMedCentral Wang JB, Huang CM, Zheng CH, Li P, Xie JW, Lin JX, Lu J (2014) Role of 3DCT in laparoscopic total gastrectomy with spleen-preserving splenic lymph node dissection. World J Gastroenterol 20(16):4797–4805CrossRefPubMedPubMedCentral
8.
go back to reference Takiguchi S, Sekimoto M, Fujiwara Y, Yasuda T, Yano M, Hori M, Murakami T, Nakamura H, Monden M (2004) Laparoscopic lymph node dissection for gastric cancer with intraoperative navigation using three-dimensional angio computed tomography images reconstructed as laparoscopic view. Surg Endosc 18(1):106–110CrossRefPubMed Takiguchi S, Sekimoto M, Fujiwara Y, Yasuda T, Yano M, Hori M, Murakami T, Nakamura H, Monden M (2004) Laparoscopic lymph node dissection for gastric cancer with intraoperative navigation using three-dimensional angio computed tomography images reconstructed as laparoscopic view. Surg Endosc 18(1):106–110CrossRefPubMed
9.
go back to reference Kanamoto T, Matsuki M, Okuda J, Inada Y, Tatsugami F, Tanikake M, Yoshikawa S, Narabayashi I, Kawasaki H, Tanaka K, Yamamoto T, Tanigawa N, Egashira Y, Shibayama Y (2007) Preoperative evaluation of local invasion and metastatic lymph nodes of colorectal cancer and mesenteric vascular variations using multidetector-row computed tomography before laparoscopic surgery. J Comput Assist Tomogr 31(6):831–839CrossRefPubMed Kanamoto T, Matsuki M, Okuda J, Inada Y, Tatsugami F, Tanikake M, Yoshikawa S, Narabayashi I, Kawasaki H, Tanaka K, Yamamoto T, Tanigawa N, Egashira Y, Shibayama Y (2007) Preoperative evaluation of local invasion and metastatic lymph nodes of colorectal cancer and mesenteric vascular variations using multidetector-row computed tomography before laparoscopic surgery. J Comput Assist Tomogr 31(6):831–839CrossRefPubMed
10.
go back to reference Sakaguchi T, Suzuki S, Morita Y, Oishi K, Suzuki A, Fukumoto K, Inaba K, Kamiya K, Ota M, Setoguchi T, Takehara Y, Nasu H, Nakamura S, Konno H (2010) Analysis of anatomic variants of mesenteric veins by 3-dimensional portography using multidetector-row computed tomography. Am J Surg 200(1):15–22CrossRefPubMed Sakaguchi T, Suzuki S, Morita Y, Oishi K, Suzuki A, Fukumoto K, Inaba K, Kamiya K, Ota M, Setoguchi T, Takehara Y, Nasu H, Nakamura S, Konno H (2010) Analysis of anatomic variants of mesenteric veins by 3-dimensional portography using multidetector-row computed tomography. Am J Surg 200(1):15–22CrossRefPubMed
11.
go back to reference Spasojevic M, Stimec BV, Dyrbekk AP, Tepavcevic Z, Edwin B, Bakka A et al (2013) Lymph node distribution in the d3 area of the right mesocolon: implications for an anatomically correct cancer resection. A postmortem study. Dis Colon Rectum 56(12):1381–1387CrossRefPubMed Spasojevic M, Stimec BV, Dyrbekk AP, Tepavcevic Z, Edwin B, Bakka A et al (2013) Lymph node distribution in the d3 area of the right mesocolon: implications for an anatomically correct cancer resection. A postmortem study. Dis Colon Rectum 56(12):1381–1387CrossRefPubMed
12.
go back to reference Nesgaard JM, Stimec BV, Soulie P, Edwin B, Bakka A, Ignjatovic D (2018) Defining minimal clearances for adequate lymphatic resection relevant to right colectomy for cancer: a post-mortem study. Surg Endosc 32:3806–3812CrossRefPubMed Nesgaard JM, Stimec BV, Soulie P, Edwin B, Bakka A, Ignjatovic D (2018) Defining minimal clearances for adequate lymphatic resection relevant to right colectomy for cancer: a post-mortem study. Surg Endosc 32:3806–3812CrossRefPubMed
13.
go back to reference Negoi I, Beuran M, Hostiuc S, Negoi RI, Inoue Y (2018) Surgical anatomy of the superior mesenteric vessels related to colon and pancreatic surgery: a systematic review and meta-analysis. Sci Rep 8(1):4184CrossRefPubMedPubMedCentral Negoi I, Beuran M, Hostiuc S, Negoi RI, Inoue Y (2018) Surgical anatomy of the superior mesenteric vessels related to colon and pancreatic surgery: a systematic review and meta-analysis. Sci Rep 8(1):4184CrossRefPubMedPubMedCentral
14.
go back to reference Liang JT, Lai HS, Huang J, Sun CT (2015) Long-term oncologic results of laparoscopic D3 lymphadenectomy with complete mesocolic excision for right-sided colon cancer with clinically positive lymph nodes. Surg Endosc 29(8):2394–2401CrossRef Liang JT, Lai HS, Huang J, Sun CT (2015) Long-term oncologic results of laparoscopic D3 lymphadenectomy with complete mesocolic excision for right-sided colon cancer with clinically positive lymph nodes. Surg Endosc 29(8):2394–2401CrossRef
15.
go back to reference Feng B, Sun J, Ling TL, Lu AG, Wang ML, Chen XY, Ma JJ, Li JW, Zang L, Han DP, Zheng MH (2012) Laparoscopic complete mesocolic excision (CME) with medial access for right-hemi colon cancer: feasibility and technical strategies. Surg Endosc 26(12):3669–3675CrossRefPubMed Feng B, Sun J, Ling TL, Lu AG, Wang ML, Chen XY, Ma JJ, Li JW, Zang L, Han DP, Zheng MH (2012) Laparoscopic complete mesocolic excision (CME) with medial access for right-hemi colon cancer: feasibility and technical strategies. Surg Endosc 26(12):3669–3675CrossRefPubMed
16.
go back to reference Bae SU, Saklani AP, Lim DR, Kim DW, Hur H, Min BS, Baik SH, Lee KY, Kim NK (2014) Laparoscopic-assisted versus open complete mesocolic excision and central vascular ligation for right-sided colon cancer. Ann Surg Oncol 21(7):2288–2294CrossRefPubMed Bae SU, Saklani AP, Lim DR, Kim DW, Hur H, Min BS, Baik SH, Lee KY, Kim NK (2014) Laparoscopic-assisted versus open complete mesocolic excision and central vascular ligation for right-sided colon cancer. Ann Surg Oncol 21(7):2288–2294CrossRefPubMed
17.
go back to reference Pelz JOW, Wagner J, Lichthardt S, Baur J, Kastner C, Matthes N, Germer CT, Wiegering A (2018) Laparoscopic right-sided colon resection for colon cancer-has the control group so far been chosen correctly? World J Surg Oncol 16(1):117CrossRefPubMedPubMedCentral Pelz JOW, Wagner J, Lichthardt S, Baur J, Kastner C, Matthes N, Germer CT, Wiegering A (2018) Laparoscopic right-sided colon resection for colon cancer-has the control group so far been chosen correctly? World J Surg Oncol 16(1):117CrossRefPubMedPubMedCentral
18.
go back to reference Lee SD, Lim SB (2009) D3 lymphadenectomy using a medial to lateral approach for curable right-sided colon cancer. Int J Color Dis 24(3):295–300CrossRef Lee SD, Lim SB (2009) D3 lymphadenectomy using a medial to lateral approach for curable right-sided colon cancer. Int J Color Dis 24(3):295–300CrossRef
19.
go back to reference Ignjatovic D, Sund S, Stimec B, Bergamaschi R (2007) Vascular relationships in right colectomy for cancer: clinical implications. Tech Coloproctol 11(3):247–250CrossRefPubMed Ignjatovic D, Sund S, Stimec B, Bergamaschi R (2007) Vascular relationships in right colectomy for cancer: clinical implications. Tech Coloproctol 11(3):247–250CrossRefPubMed
20.
go back to reference Natsume T, Shuto K, Yanagawa N, Akai T, Kawahira H, Hayashi H, Matsubara H (2011) The classification of anatomic variations in the perigastric vessels by dual-phase CT to reduce intraoperative bleeding during laparoscopic gastrectomy. Surg Endosc 25(5):1420–1424CrossRefPubMed Natsume T, Shuto K, Yanagawa N, Akai T, Kawahira H, Hayashi H, Matsubara H (2011) The classification of anatomic variations in the perigastric vessels by dual-phase CT to reduce intraoperative bleeding during laparoscopic gastrectomy. Surg Endosc 25(5):1420–1424CrossRefPubMed
21.
go back to reference Galizia G, Lieto E, De Vita F, Ferraraccio F, Zamboli A, Mabilia A et al (2014) Is complete mesocolic excision with central vascular ligation safe and effective in the surgical treatment of right-sided colon cancers? A prospective study. Int J Color Dis 29(1):89–97CrossRef Galizia G, Lieto E, De Vita F, Ferraraccio F, Zamboli A, Mabilia A et al (2014) Is complete mesocolic excision with central vascular ligation safe and effective in the surgical treatment of right-sided colon cancers? A prospective study. Int J Color Dis 29(1):89–97CrossRef
22.
go back to reference Ogino T, Takemasa I, Horitsugi G, Furuyashiki M, Ohta K, Uemura M et al (2014) Preoperative evaluation of venous anatomy in laparoscopic complete mesocolic excision for right colon cancer. Ann Surg Oncol 21(Suppl 3):S429–S435CrossRefPubMed Ogino T, Takemasa I, Horitsugi G, Furuyashiki M, Ohta K, Uemura M et al (2014) Preoperative evaluation of venous anatomy in laparoscopic complete mesocolic excision for right colon cancer. Ann Surg Oncol 21(Suppl 3):S429–S435CrossRefPubMed
23.
go back to reference Storli KE, Sondenaa K, Furnes B, Nesvik I, Gudlaugsson E, Bukholm I et al (2014) Short term results of complete (D3) vs. standard (D2) mesenteric excision in colon cancer shows improved outcome of complete mesenteric excision in patients with TNM stages I-II. Tech Coloproctol 18(6):557–564CrossRefPubMed Storli KE, Sondenaa K, Furnes B, Nesvik I, Gudlaugsson E, Bukholm I et al (2014) Short term results of complete (D3) vs. standard (D2) mesenteric excision in colon cancer shows improved outcome of complete mesenteric excision in patients with TNM stages I-II. Tech Coloproctol 18(6):557–564CrossRefPubMed
24.
go back to reference Kessler H, Hohenberger W (2013) Extended lymphadenectomy in colon cancer is crucial. World J Surg 37(8):1789–1798CrossRefPubMed Kessler H, Hohenberger W (2013) Extended lymphadenectomy in colon cancer is crucial. World J Surg 37(8):1789–1798CrossRefPubMed
25.
go back to reference Kotake K, Mizuguchi T, Moritani K, Wada O, Ozawa H, Oki I, Sugihara K (2014) Impact of D3 lymph node dissection on survival for patients with T3 and T4 colon cancer. Int J Color Dis 29(7):847–852CrossRef Kotake K, Mizuguchi T, Moritani K, Wada O, Ozawa H, Oki I, Sugihara K (2014) Impact of D3 lymph node dissection on survival for patients with T3 and T4 colon cancer. Int J Color Dis 29(7):847–852CrossRef
26.
go back to reference Munkedal DL, West NP, Iversen LH, Hagemann-Madsen R, Quirke P, Laurberg S (2014) Implementation of complete mesocolic excision at a university hospital in Denmark: an audit of consecutive, prospectively collected colon cancer specimens. Eur J Surg Oncol 40(11):1494–1501CrossRefPubMed Munkedal DL, West NP, Iversen LH, Hagemann-Madsen R, Quirke P, Laurberg S (2014) Implementation of complete mesocolic excision at a university hospital in Denmark: an audit of consecutive, prospectively collected colon cancer specimens. Eur J Surg Oncol 40(11):1494–1501CrossRefPubMed
27.
go back to reference Kotake K, Kobayashi H, Asano M, Ozawa H, Sugihara K (2015) Influence of extent of lymph node dissection on survival for patients with pT2 colon cancer. Int J Color Dis 30(6):813–820CrossRef Kotake K, Kobayashi H, Asano M, Ozawa H, Sugihara K (2015) Influence of extent of lymph node dissection on survival for patients with pT2 colon cancer. Int J Color Dis 30(6):813–820CrossRef
28.
go back to reference Cho MS, Baek SJ, Hur H, Soh Min B, Baik SH, Kyu Kim N (2015) Modified complete mesocolic excision with central vascular ligation for the treatment of right-sided colon cancer: long-term outcomes and prognostic factors. Ann Surg 261(4):708–715CrossRefPubMed Cho MS, Baek SJ, Hur H, Soh Min B, Baik SH, Kyu Kim N (2015) Modified complete mesocolic excision with central vascular ligation for the treatment of right-sided colon cancer: long-term outcomes and prognostic factors. Ann Surg 261(4):708–715CrossRefPubMed
Metadata
Title
Preoperative anatomical road mapping reduces variability of operating time, estimated blood loss, and lymph node yield in right colectomy with extended D3 mesenterectomy for cancer
Authors
Christer-Daniel Willard
Erik Kjaestad
Bojan V. Stimec
Bjorn Edwin
Dejan Ignjatovic
RCC Study Group
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 1/2019
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-018-3177-5

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