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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 12/2017

Open Access 01-12-2017 | Original Article

Safety of endoscopic mucosal resection (EMR) of large non-pedunculated colorectal adenomas in the elderly

Authors: K. Bronsgeest, J. F. Huisman, A. Langers, J. J. Boonstra, B. E. Schenk, W. H. de Vos tot Nederveen Cappel, H. F. A. Vasen, J. C. H. Hardwick

Published in: International Journal of Colorectal Disease | Issue 12/2017

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Abstract

Background

Endoscopic mucosal resection (EMR) has been proven to be safe and effective for the treatment of colorectal adenomas. However, data are limited on the safety of this technique for large polyps and in elderly patients. Aims of our study were to examine the bleeding and perforation rates in patients with large non-pedunculated adenomas (≥20mm) and to evaluate the influence of size (≥40mm) and age (≥75 years) on the complication rates.

Methods

In this multicenter retrospective study, patients who underwent EMR of non-pedunculated adenomas ≥20mm between January 2012 and March 2016 were included. The demographics of the patients, the use of antithrombotic drugs, size of the polyps, type of resection, pathology report, occurrence of post-polypectomy bleeding, and perforation- and recurrence rate were collected.

Results

In 343 patients, 412 adenomas were removed. Eighty patients (23.3%) were ≥75 years of age, 138 polyps (33.5%) were ≥40mm. Bleeding complications were observed in 28 cases (6.8%) and were found significantly more frequent in adenomas ≥40mm, independent of the use of antithrombotic therapy. Five perforations (1.2%) were described, not related to the size of the polyp. There was no significant difference in complication rates between patients <75 years and patients ≥75 years. Bleeding complications rates were significantly higher in patients receiving double antithrombotic therapy.

Conclusion

EMR is safe in elderly patients. EMR of adenomas of ≥40mm was associated with more bleeding complications. Future studies should address how the bleeding rates can be reduced in these patients, especially in those who use double antithrombotic treatment.
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Metadata
Title
Safety of endoscopic mucosal resection (EMR) of large non-pedunculated colorectal adenomas in the elderly
Authors
K. Bronsgeest
J. F. Huisman
A. Langers
J. J. Boonstra
B. E. Schenk
W. H. de Vos tot Nederveen Cappel
H. F. A. Vasen
J. C. H. Hardwick
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 12/2017
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-017-2892-7

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