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Published in: International Journal of Colorectal Disease 7/2016

01-07-2016 | Review

Literature review of the role of lateral internal sphincterotomy (LIS) when combined with excisional hemorrhoidectomy

Authors: Sameh Hany Emile, Mohamed Youssef, Hossam Elfeki, Waleed Thabet, Tito M. Abd El-Hamed, Mohamed Farid

Published in: International Journal of Colorectal Disease | Issue 7/2016

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Abstract

Background and aim

Pain following hemorrhoidectomy is a distressing sequel to the procedure. Various methods have been used to alleviate post-hemorrhoidectomy pain; among these methods is the lateral internal sphincterotomy (LIS). This review aimed to analyze all studies that evaluated the impact of LIS on the outcome of excisional hemorrhoidectomy.

Patients and methods

Seventeen studies were included after organized search of the literature using electronic databases including PubMed/Medline and EMBASE. The studies included comprised 2180 patients with median age of 44 years. Variables selected for the review comprised patients’ characteristics, postoperative pain assessment, analgesic consumption, and complications as fecal incontinence (FI), urinary retention, and anal stenosis.

Results

Overall, 933 (42.7 %) patients underwent LIS. Almost all studies assessing postoperative pain reported lower pain scores and less need for postoperative analgesia among patients who underwent LIS in comparison with patients who did not have LIS. Eleven of 13 studies that assessed continence state postoperatively reported higher rates of FI among patients who had LIS with a median rate of 7.7 % versus 1.25 % for patients who did not have LIS. Incidence of urinary retention after LIS ranged from 0 to 60 %. Anal stenosis occurred in 0–14.5 % of patients who had LIS versus 0–36.4 % in patients without LIS.

Conclusion

LIS effectively reduced postoperative pain and need for analgesics following excisional hemorrhoidectomy. LIS also managed to decrease incidence of postoperative urinary retention and anal stenosis significantly. The negative aspect of adding LIS to excisional hemorrhoidectomy was developing minor FI after surgery which was temporary in duration.
Literature
1.
go back to reference Loder PB, Kamm MA, Nicholls RJ, Phillips RK (1994) Haemorrhoids: pathology, pathophysiology and aetiology. Br J Surg 81:946–954CrossRefPubMed Loder PB, Kamm MA, Nicholls RJ, Phillips RK (1994) Haemorrhoids: pathology, pathophysiology and aetiology. Br J Surg 81:946–954CrossRefPubMed
2.
go back to reference Arroyo A, Pérez F, Miranda E, Serrano P, Candela F, Lacueva J, Hernández H, Calpena R (2004) Open versus closed day-case hemorrhoidectomy: is there any difference? Results of a prospective randomised study. Int J Colorectal Dis 19:370–373CrossRefPubMed Arroyo A, Pérez F, Miranda E, Serrano P, Candela F, Lacueva J, Hernández H, Calpena R (2004) Open versus closed day-case hemorrhoidectomy: is there any difference? Results of a prospective randomised study. Int J Colorectal Dis 19:370–373CrossRefPubMed
3.
go back to reference MacRae HM, McLeod RS (1995) Comparison of hemorrhoidal treatment modalities. A meta-analysis. Dis Colon Rectum 38:687–694CrossRefPubMed MacRae HM, McLeod RS (1995) Comparison of hemorrhoidal treatment modalities. A meta-analysis. Dis Colon Rectum 38:687–694CrossRefPubMed
4.
go back to reference Rahimi R, Abdollahi M (2012) A systematic review of the topical drugs for post- hemorrhoidectomy pain. Int J Pharmacol 8:628–637CrossRef Rahimi R, Abdollahi M (2012) A systematic review of the topical drugs for post- hemorrhoidectomy pain. Int J Pharmacol 8:628–637CrossRef
5.
go back to reference Lohsiriwat D, Lohsiriwat V (2005) Outpatient hemorrhoidectomy under perianal anesthetics infiltration. J Med Assoc Thai 88:1821–1824PubMed Lohsiriwat D, Lohsiriwat V (2005) Outpatient hemorrhoidectomy under perianal anesthetics infiltration. J Med Assoc Thai 88:1821–1824PubMed
6.
go back to reference Wasvary HJ, Hain J, Mosed-Vogel M et al (2001) Randomized, prospective, double-blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy. Dis Colon Rectum 44:1069–1073CrossRefPubMed Wasvary HJ, Hain J, Mosed-Vogel M et al (2001) Randomized, prospective, double-blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy. Dis Colon Rectum 44:1069–1073CrossRefPubMed
7.
go back to reference Balfour L, Stoijkovic SG, Botterill ID et al (2002) A randomized, double blind trial of the effect of metronidazole on pain after closed hemorrhoidectomy. Dis Colon Rectum 45:1186–1190CrossRefPubMed Balfour L, Stoijkovic SG, Botterill ID et al (2002) A randomized, double blind trial of the effect of metronidazole on pain after closed hemorrhoidectomy. Dis Colon Rectum 45:1186–1190CrossRefPubMed
8.
go back to reference Vinson-Bonnet B, Coltat JC, Fingerhut A et al (2002) Local infiltration with ropivacaine improves immediate postoperative pain control after hemorrhoidal surgery. Dis Colon Rectum 45:104–108CrossRefPubMed Vinson-Bonnet B, Coltat JC, Fingerhut A et al (2002) Local infiltration with ropivacaine improves immediate postoperative pain control after hemorrhoidal surgery. Dis Colon Rectum 45:104–108CrossRefPubMed
9.
go back to reference Khubchandani IT (2002) Internal sphincterotomy with hemorrhoidectomy does not relieve pain: a prospective, randomized study. Dis Colon Rectum 45:1452–1457CrossRefPubMed Khubchandani IT (2002) Internal sphincterotomy with hemorrhoidectomy does not relieve pain: a prospective, randomized study. Dis Colon Rectum 45:1452–1457CrossRefPubMed
10.
go back to reference Galizia G, Lieto E, Castellano P et al (2000) Lateral internal sphincterotomy together with haemorrhoidectomy for treatment of haemorrhoids: a randomized prospective study. Eur J Surg 166:223–228CrossRefPubMed Galizia G, Lieto E, Castellano P et al (2000) Lateral internal sphincterotomy together with haemorrhoidectomy for treatment of haemorrhoids: a randomized prospective study. Eur J Surg 166:223–228CrossRefPubMed
11.
go back to reference Di Bella F, Estenne G (1990) Indications for internal, medioposterior with anoplasty or lateral sphincterotomy during hemorrhoidectomy: our experience. Minerva Chir 45:361–363PubMed Di Bella F, Estenne G (1990) Indications for internal, medioposterior with anoplasty or lateral sphincterotomy during hemorrhoidectomy: our experience. Minerva Chir 45:361–363PubMed
12.
go back to reference Asfar SK, Juma TH, Ala-Edeen T (1988) Hemorrhoidectomy and sphincterotomy. A prospective study comparing the effectiveness of anal stretch and sphincterotomy in reducing pain after hemorrhoidectomy. Dis Colon Rectum 31:181–185CrossRefPubMed Asfar SK, Juma TH, Ala-Edeen T (1988) Hemorrhoidectomy and sphincterotomy. A prospective study comparing the effectiveness of anal stretch and sphincterotomy in reducing pain after hemorrhoidectomy. Dis Colon Rectum 31:181–185CrossRefPubMed
13.
go back to reference Amorotti C, Mosca D, Trenti C, Pintaudi U (2003) Usefulness of lateral internal sphincterotomy combined with hemorrhoidectomy by the Milligan-Morgan’s technique: results of a prospective randomized trial. Chir Ital 55(6):879–86PubMed Amorotti C, Mosca D, Trenti C, Pintaudi U (2003) Usefulness of lateral internal sphincterotomy combined with hemorrhoidectomy by the Milligan-Morgan’s technique: results of a prospective randomized trial. Chir Ital 55(6):879–86PubMed
14.
go back to reference Chauhan A, Tiwari S, Mishra VK, Bhatia PK (2009) Comparison of internal sphincterotomy with topical diltiazem for post-hemorrhoidectomy pain relief, a prospective randomized trial. J Postgrad Med 55(1):22–6CrossRefPubMed Chauhan A, Tiwari S, Mishra VK, Bhatia PK (2009) Comparison of internal sphincterotomy with topical diltiazem for post-hemorrhoidectomy pain relief, a prospective randomized trial. J Postgrad Med 55(1):22–6CrossRefPubMed
15.
go back to reference Mukadam P, Masu S (2014) Internal sphincterotomy as a postoperative pain relieving method in patients operated for open hemorrhoidectomy. J Res Med Den Sci 2(1):55–58CrossRef Mukadam P, Masu S (2014) Internal sphincterotomy as a postoperative pain relieving method in patients operated for open hemorrhoidectomy. J Res Med Den Sci 2(1):55–58CrossRef
16.
go back to reference De Lucaa S, Tomaselloa G, Damianoa, Palumboa V, Spinellia G, Giovialea M, Accardoc F et al (2012) The management of postoperative pain after hemorrhoidectomy: analysis of three methodics. Acta Med Mediterr 28:301 De Lucaa S, Tomaselloa G, Damianoa, Palumboa V, Spinellia G, Giovialea M, Accardoc F et al (2012) The management of postoperative pain after hemorrhoidectomy: analysis of three methodics. Acta Med Mediterr 28:301
17.
go back to reference Mathai V, Ong BC, Ho YH (1996) Randomized controlled trial of lateral internal sphincterotomy with haemorrhoidectomy. Br J Surg 83(3):380–2CrossRefPubMed Mathai V, Ong BC, Ho YH (1996) Randomized controlled trial of lateral internal sphincterotomy with haemorrhoidectomy. Br J Surg 83(3):380–2CrossRefPubMed
18.
go back to reference Taha S (2013) Routine internal sphincterotomy with hemorrhoidectomy for third and fourth degree hemorrhoids greatly improves the outcome. IJGE 1(4) Taha S (2013) Routine internal sphincterotomy with hemorrhoidectomy for third and fourth degree hemorrhoids greatly improves the outcome. IJGE 1(4)
19.
go back to reference Kanellos I, Zacharakis E, Christoforidis E, Angelopoulos S, Kanellos D, Pramateftakis MG, Betsis D (2005) Usefulness of lateral internal sphincterotomy in reducing postoperative pain after open hemorrhoidectomy. World J Surg 29(4):464–8CrossRefPubMed Kanellos I, Zacharakis E, Christoforidis E, Angelopoulos S, Kanellos D, Pramateftakis MG, Betsis D (2005) Usefulness of lateral internal sphincterotomy in reducing postoperative pain after open hemorrhoidectomy. World J Surg 29(4):464–8CrossRefPubMed
20.
go back to reference Hosseini SV, Sharifi K, Ahmadfard A, Mosallaei M, Pourahmad S, Bolandparvaz S (2007) Role of internal sphincterotomy in the treatment of hemorrhoids: a randomized clinical trial. Arch Iran Med 10(4):504–8PubMed Hosseini SV, Sharifi K, Ahmadfard A, Mosallaei M, Pourahmad S, Bolandparvaz S (2007) Role of internal sphincterotomy in the treatment of hemorrhoids: a randomized clinical trial. Arch Iran Med 10(4):504–8PubMed
21.
go back to reference Junior HM, Moreira J, Moreira H, Iguma C, Almeida A, de Magalhães C (2007) Open hemorrhoidectomy with associated lateral internal sphincterotomy for treatment of hemorrhoids: advantage or disadvantage? Rev Bras Colo Proctol 27(3):293–303CrossRef Junior HM, Moreira J, Moreira H, Iguma C, Almeida A, de Magalhães C (2007) Open hemorrhoidectomy with associated lateral internal sphincterotomy for treatment of hemorrhoids: advantage or disadvantage? Rev Bras Colo Proctol 27(3):293–303CrossRef
22.
23.
go back to reference Abedidost S, Poya M, Shafe SM (2011) The effect of internal sphincterotomy on post hemorrhoidectomy pain. Arak Med Univ J 14(56):58–63 Abedidost S, Poya M, Shafe SM (2011) The effect of internal sphincterotomy on post hemorrhoidectomy pain. Arak Med Univ J 14(56):58–63
24.
go back to reference Das DK, Choudhury UC, Lim ZS (2013) Effectiveness of internal sphincterotomy in reducing post open hemorrhoidectomy pain: a randomized comparative clinical study. Int J Collab Res Intern Med Public Health 5(6):428 Das DK, Choudhury UC, Lim ZS (2013) Effectiveness of internal sphincterotomy in reducing post open hemorrhoidectomy pain: a randomized comparative clinical study. Int J Collab Res Intern Med Public Health 5(6):428
25.
go back to reference Raza M, Khan A, Kamran R, Waqas K, Yusuf A (2013) Hemorrhoidectomy with and without lateral internal sphinterotomy. J Rawalpindi Med Coll 17(2):189–191 Raza M, Khan A, Kamran R, Waqas K, Yusuf A (2013) Hemorrhoidectomy with and without lateral internal sphinterotomy. J Rawalpindi Med Coll 17(2):189–191
26.
go back to reference Lu M, Shi GY, Wang GQ, Wu Y, Liu Y, Wen H (2013) Milligan-Morgan hemorrhoidectomy with anal cushion suspension and partial internal sphincter resection for circumferential mixed hemorrhoids. World J Gastroenterol 19(30):5011–5015CrossRefPubMedPubMedCentral Lu M, Shi GY, Wang GQ, Wu Y, Liu Y, Wen H (2013) Milligan-Morgan hemorrhoidectomy with anal cushion suspension and partial internal sphincter resection for circumferential mixed hemorrhoids. World J Gastroenterol 19(30):5011–5015CrossRefPubMedPubMedCentral
27.
go back to reference McNamara MJ, Percy JP, Fielding IR (1990) A manometric study of anal fissure treated by subcutaneous lateral internal sphincterotomy. Ann Surg 211(2):235–8CrossRefPubMedPubMedCentral McNamara MJ, Percy JP, Fielding IR (1990) A manometric study of anal fissure treated by subcutaneous lateral internal sphincterotomy. Ann Surg 211(2):235–8CrossRefPubMedPubMedCentral
28.
go back to reference Nielsen MB, Rasmussen OO, Pedersen JF et al (1993) Risk of sphincter damage and anal incontinence after anal dilatation for fissure-in-ano. An endosonographic study. Dis Colon Rectum 36:677–680CrossRefPubMed Nielsen MB, Rasmussen OO, Pedersen JF et al (1993) Risk of sphincter damage and anal incontinence after anal dilatation for fissure-in-ano. An endosonographic study. Dis Colon Rectum 36:677–680CrossRefPubMed
29.
go back to reference Johanson JF, Sonnenberg A (1990) Prevalence of hemorrhoids and chronic constipation. An epidemiologic study. Gastroenterology 98:380–386PubMed Johanson JF, Sonnenberg A (1990) Prevalence of hemorrhoids and chronic constipation. An epidemiologic study. Gastroenterology 98:380–386PubMed
30.
go back to reference Nivatvongs S (2007) Hemorrhoids. In: Gordon P, Nivatvongs S (eds) Principles and practice of surgery for the colon, rectum, and anus. Informa Healthcare, New York, p 150 Nivatvongs S (2007) Hemorrhoids. In: Gordon P, Nivatvongs S (eds) Principles and practice of surgery for the colon, rectum, and anus. Informa Healthcare, New York, p 150
31.
go back to reference Ho YH, Tan M (1997) Ambulatory anorectal manometric findings in patients before and after haemorrhoidectom. Int J Colorectal Dis 12:296–297CrossRefPubMed Ho YH, Tan M (1997) Ambulatory anorectal manometric findings in patients before and after haemorrhoidectom. Int J Colorectal Dis 12:296–297CrossRefPubMed
32.
go back to reference Coskun A, Duzgun SA, Uzunkoy A, Bozer M, Aslan O, Canbeyli B (2001) Nitroderm TTS band application for pain after hemorrhoidectomy. Dis Colon Rectum 44(5):680–5CrossRefPubMed Coskun A, Duzgun SA, Uzunkoy A, Bozer M, Aslan O, Canbeyli B (2001) Nitroderm TTS band application for pain after hemorrhoidectomy. Dis Colon Rectum 44(5):680–5CrossRefPubMed
33.
go back to reference Eisenhammer S (1969) Proper principles and practices in the surgical management of hemorrhoids. Dis Colon Rectum 12(4):288–305CrossRefPubMed Eisenhammer S (1969) Proper principles and practices in the surgical management of hemorrhoids. Dis Colon Rectum 12(4):288–305CrossRefPubMed
34.
go back to reference Elton C, Sen P, Montgomery AC (2001) Initial study to assess the effects of topical glyceryl trinitrate for pain after haemorrhoidectomy. Int J Surg Investig 2:353–357PubMed Elton C, Sen P, Montgomery AC (2001) Initial study to assess the effects of topical glyceryl trinitrate for pain after haemorrhoidectomy. Int J Surg Investig 2:353–357PubMed
35.
go back to reference Hwang DY, Yoon SG, Kim HS, Lee JK, Kim KY (2003) Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, doubleblind, placebo-controlled trial. Dis Colon Rectum 46:950–954CrossRefPubMed Hwang DY, Yoon SG, Kim HS, Lee JK, Kim KY (2003) Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, doubleblind, placebo-controlled trial. Dis Colon Rectum 46:950–954CrossRefPubMed
36.
go back to reference Amoli HA, Notash AY, Shahandashti FJ, Kenari AY, Ashraf H (2009) A randomized, prospective, double-blind, placebo-controlled trial of the effect of topical diltiazem on post-hemorrhoidectomy pain. Colorectal Dis 13(3):328–32CrossRef Amoli HA, Notash AY, Shahandashti FJ, Kenari AY, Ashraf H (2009) A randomized, prospective, double-blind, placebo-controlled trial of the effect of topical diltiazem on post-hemorrhoidectomy pain. Colorectal Dis 13(3):328–32CrossRef
37.
go back to reference Perrotti P, Dominici P, Grossi E, Cerutti R, Antropoli C (2010) Topical nifedipine with lidocaine ointment versus active control for pain after hemorrhoidectomy: results of a multicentre, prospective, randomized, double-blind study. Can J Surg 53:17–24PubMedPubMedCentral Perrotti P, Dominici P, Grossi E, Cerutti R, Antropoli C (2010) Topical nifedipine with lidocaine ointment versus active control for pain after hemorrhoidectomy: results of a multicentre, prospective, randomized, double-blind study. Can J Surg 53:17–24PubMedPubMedCentral
38.
go back to reference Davies J, Duffy D, Boyt N, Aghahoseini A, Alexander D, Leveson S (2003) Botulinum toxin (botox) reduces pain after hemorrhoidectomy: results of a double-blind, randomized study. Dis Colon Rectum 46:1097–1102CrossRefPubMed Davies J, Duffy D, Boyt N, Aghahoseini A, Alexander D, Leveson S (2003) Botulinum toxin (botox) reduces pain after hemorrhoidectomy: results of a double-blind, randomized study. Dis Colon Rectum 46:1097–1102CrossRefPubMed
39.
go back to reference Ho YH, Seow-Choen F, Low JY, Tan M, Leong AP (1997) Randomized controlled trial of trimebutine (anal sphincter relaxant) for pain after haemorrhoidectomy. Br J Surg 84(3):377–9CrossRefPubMed Ho YH, Seow-Choen F, Low JY, Tan M, Leong AP (1997) Randomized controlled trial of trimebutine (anal sphincter relaxant) for pain after haemorrhoidectomy. Br J Surg 84(3):377–9CrossRefPubMed
40.
go back to reference Ram E, Alper D, Stein G, Bramnik Z, Dreznik Z (2005) Internal anal sphincter function following lateral internal sphincterotomy for anal fissure: a long-term manometric study. Ann Surg 242(2):208–211CrossRefPubMedPubMedCentral Ram E, Alper D, Stein G, Bramnik Z, Dreznik Z (2005) Internal anal sphincter function following lateral internal sphincterotomy for anal fissure: a long-term manometric study. Ann Surg 242(2):208–211CrossRefPubMedPubMedCentral
41.
go back to reference Casillas S, Hull TL, Zutshi M, Trzcinski R, Bast JF, Xu M (2005) Incontinence after a lateral internal sphincterotomy: are we underestimating it? Dis Colon Rectum 48(6):1193–9CrossRefPubMed Casillas S, Hull TL, Zutshi M, Trzcinski R, Bast JF, Xu M (2005) Incontinence after a lateral internal sphincterotomy: are we underestimating it? Dis Colon Rectum 48(6):1193–9CrossRefPubMed
42.
go back to reference Garg P, Garg M, Menon GR (2013) Long-term continence disturbance after lateral internal sphincterotomy for chronic anal fissure: a systematic review and meta-analysis. Colorectal Dis 15(3):e104–17. doi:10.1111/codi.12108 CrossRefPubMed Garg P, Garg M, Menon GR (2013) Long-term continence disturbance after lateral internal sphincterotomy for chronic anal fissure: a systematic review and meta-analysis. Colorectal Dis 15(3):e104–17. doi:10.​1111/​codi.​12108 CrossRefPubMed
43.
go back to reference Elsebae MM (2007) A study of fecal incontinence in patients with chronic anal fissure: prospective, randomized, controlled trial of the extent of internal anal sphincter division during lateral sphincterotomy. World J Surg 31(10):2052–7CrossRefPubMed Elsebae MM (2007) A study of fecal incontinence in patients with chronic anal fissure: prospective, randomized, controlled trial of the extent of internal anal sphincter division during lateral sphincterotomy. World J Surg 31(10):2052–7CrossRefPubMed
44.
go back to reference Tjandra JJ, Han WR, Ooi BS, Nagesh A, Thorne M (2001) Faecal incontinence after lateral internal sphincterotomy is often associated with coexisting occult sphincter defects: a study using endoanal ultrasonography. ANZ J Surg 71(10):598–602CrossRefPubMed Tjandra JJ, Han WR, Ooi BS, Nagesh A, Thorne M (2001) Faecal incontinence after lateral internal sphincterotomy is often associated with coexisting occult sphincter defects: a study using endoanal ultrasonography. ANZ J Surg 71(10):598–602CrossRefPubMed
45.
go back to reference Chik B, Law WL, Choi HK (2006) Urinary retention after hemorrhoidectomy: impact of stapled hemorrhoidectomy. Asian J Surg 29(4):233–7CrossRefPubMed Chik B, Law WL, Choi HK (2006) Urinary retention after hemorrhoidectomy: impact of stapled hemorrhoidectomy. Asian J Surg 29(4):233–7CrossRefPubMed
Metadata
Title
Literature review of the role of lateral internal sphincterotomy (LIS) when combined with excisional hemorrhoidectomy
Authors
Sameh Hany Emile
Mohamed Youssef
Hossam Elfeki
Waleed Thabet
Tito M. Abd El-Hamed
Mohamed Farid
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 7/2016
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-016-2603-9

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