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International Journal of Colorectal Disease

Published in:

01-06-2016 | Original Article

Abdominoperineal resection and perineal wound healing in recurrent, persistent, or primary anal carcinoma

Authors: J. Hardt, S. Mai, C. Weiß, Peter Kienle, J. Magdeburg

Published in: International Journal of Colorectal Disease | Issue 6/2016

Abstract

Purpose

Chemoradiotherapy is the standard treatment for squamous cell anal cancer. Salvage abdominoperineal resection (APR) is usually reserved for patients presenting with recurrent or persistent disease. Aim of our study was to review the outcomes of salvage surgery and perineal wound healing with or without a vertical rectus abdominis myocutaneous (VRAM) flap in a single institution over a 6-year period.

Methods

Data of all patients with biopsy-proven squamous cell anal cancer treated with chemoradiation at the University Medical Center Mannheim were recorded prospectively. Medical records of all patients who underwent salvage surgery for anal carcinoma between June 2008 and June 2014 were reviewed with regard to surgical and oncological outcomes.

Results

One hundred twenty-four patients received chemoradiation with a 5-year overall survival of 79 %. Seventeen patients required (salvage) APR for recurrent (n = 8), persistent (n = 7), or primary anal carcinoma (n = 2). Median overall survival was 33.4 months. Median duration until completion of perineal wound healing was shorter in the VRAM group (17 vs. 24.5 weeks; p = 0.0541).

Conclusions

Salvage APR has a reasonable chance of long-time survival. Perineal reconstruction with a VRAM flap may reduce the duration until completion of perineal wound healing.

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Title: Abdominoperineal resection and perineal wound healing in recurrent, persistent, or primary anal carcinoma
Authors: J. Hardt
S. Mai
C. Weiß
Peter Kienle
J. Magdeburg
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 6/2016
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-016-2575-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abdominoperineal resection and perineal wound healing in recurrent, persistent, or primary anal carcinoma

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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