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International Journal of Colorectal Disease

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Open Access 01-04-2016 | Original Article

Laparoscopic versus open surgery for rectal cancer: a meta-analysis of 3-year follow-up outcomes

Authors: Dachuan Zhao, Yibin Li, Senming Wang, Zonghai Huang

Published in: International Journal of Colorectal Disease | Issue 4/2016

Abstract

purpose

We wished to evaluate the effectiveness of laparoscopic and open surgery for patients with rectum cancer through a meta-analysis.

Methods

We searched PubMed, EMBASE, and Cochrane database until June 30, 2015, to identify eligible studies. Randomized controlled trials comparing laparoscopic with open surgery for rectum cancer were included. Meta-analysis was performed using the search strategy following the requirement of the Cochrane Library Handbook. Three-year overall survival (OS) and disease-free survival (DFS) were the main endpoints.

Results

Eight randomized controlled trials comprising 3145 patients matched the selection criteria. Meta-analysis showed no significant difference between laparoscopic and open surgery in 3-year overall survival (OS) and disease-free survival (DFS) (hazard ratio (HR)_{3-year OS} = 0.83, 95 % CI [0.68–1.01]; P = 0.06; HR_{3-year DFS} = 0.89, 95 % CI [0.75,1.05]; P = 0.16). No evidence of publication bias was observed.

Conclusion

Our meta-analysis supported the notion that based on the 3-year DFS and OS, oncological outcomes are comparable after laparoscopic and open surgery for rectal cancer.

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Title: Laparoscopic versus open surgery for rectal cancer: a meta-analysis of 3-year follow-up outcomes
Authors: Dachuan Zhao
Yibin Li
Senming Wang
Zonghai Huang
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 4/2016
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-016-2506-9

At a glance: The STEP trials

Springer Medicine

Laparoscopic versus open surgery for rectal cancer: a meta-analysis of 3-year follow-up outcomes

Abstract

purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

purpose

Methods

Results

Conclusion

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