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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 2/2016

01-02-2016 | Original Article

The frequency of early colorectal cancer derived from sessile serrated adenoma/polyps among 1858 serrated polyps from a single institution

Authors: A. Chino, N. Yamamoto, Y. Kato, K. Morishige, H. Ishikawa, T. Kishihara, J. Fujisaki, Y. Ishikawa, Y. Tamegai, M. Igarashi

Published in: International Journal of Colorectal Disease | Issue 2/2016

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Abstract

Background and aim

Sessile serrated adenoma/polyps (SSAPs) are suspected to have a high malignant potential, although few reports have evaluated the incidence of carcinomas derived from SSAPs using the new classification for serrated polyps (SPs). The aim of study was to compare the frequency of cancer coexisting with the various SP subtypes including mixed polyps (MIXs) and conventional adenomas (CADs).

Methods

A total of 18,667 CADs were identified between April 2005 and December 2011, and 1858 SPs (re-classified as SSAP, hyperplastic polyp (HP), traditional serrated adenoma (TSA), or MIX) were removed via snare polypectomy, endoscopic mucosal resection, or endoscopic sub-mucosal dissection.

Results

Among 1160 HP lesions, 1 (0.1 %) coexisting sub-mucosal invasive carcinoma (T1) was detected. Among 430 SSAP lesions, 3 (0.7 %) high-grade dysplasia (HGD/Tis) and 1 (0.2 %) T1 were detected. All of the lesions were detected in the proximal colon, with a mean tumor diameter of 18 mm (SD 9 mm). Among 212 TSA lesions, 3 (1 %) HGD/Tis were detected but no T1 cancer. Among 56 MIX lesions, 9 (16 %) HGD/Tis and 1 (2 %) T1 cancers were detected, and among 18,677 CAD lesions, 964 (5 %) HGD/Tis and 166 (1 %) T1 cancers were identified.

Conclusions

Among the resected lesions that were detected during endoscopic examination, a smaller proportion (1 %) of SSAPs harbored HGD or coexisting cancer, compared to CAD or MIX lesions. Therefore, more attention should be paid to accurately identifying lesions endoscopically for intentional resection and the surveillance of each SP subtype.
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Metadata
Title
The frequency of early colorectal cancer derived from sessile serrated adenoma/polyps among 1858 serrated polyps from a single institution
Authors
A. Chino
N. Yamamoto
Y. Kato
K. Morishige
H. Ishikawa
T. Kishihara
J. Fujisaki
Y. Ishikawa
Y. Tamegai
M. Igarashi
Publication date
01-02-2016
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 2/2016
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-015-2416-2

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