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International Journal of Colorectal Disease

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Open Access 01-01-2016 | Original Article

Practical problems of measuring depth of submucosal invasion in T1 colorectal carcinomas

Authors: Yuta Kouyama, Shin-ei Kudo, Hideyuki Miyachi, Katsuro Ichimasa, Tomokazu Hisayuki, Hiromasa Oikawa, Shingo Matsudaira, Yui J. Kimura, Masashi Misawa, Yuichi Mori, Kenta Kodama, Toyoki Kudo, Takemasa Hayashi, Kunihiko Wakamura, Atsushi Katagiri, Eiji Hidaka, Fumio Ishida, Shigeharu Hamatani

Published in: International Journal of Colorectal Disease | Issue 1/2016

Abstract

Purpose

Submucosal invasion depth (SID) in colorectal carcinoma (CRC) is an important factor in estimating risk of lymph node metastasis, but can be difficult to measure, leading to inadequate or over-extensive treatment. Here, we aimed to clarify the practical aspects of measuring SID in T1 CRC.

Methods

We investigated 568 T1 CRCs that were resected surgically at our hospital from April 2001 to December 2013, and relationships between SID and clinicopathological factors, including the means of measurement, lesion morphology, and lymph node metastasis.

Results

Of these 568 lesions, the SID was ≥1000 μm in 508 lesions. SIDs for lesions measured from the surface layer were all ≥1000 μm. Although lesions with SIDs ≥1000 μm were associated with significantly higher levels of unfavorable histologic types and lymphovascular infiltration than shallower lesions, a depth of ≥1000 μm was not a significant risk factor for lymph node metastasis (LNM) (6.7 vs. 9.8 %; P = 0.64), and no lesions for which the sole pathological factor was SID ≥1000 μm had lymph node metastasis. Protruded lesions showed deeper SIDs than other types.

Conclusions

Although we found several problems of measuring SID in this study, we also found, surprisingly, that SID is not a risk factor for lymph node metastasis, and its measurement is not needed to estimate the risk of lymph node metastasis.

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Title: Practical problems of measuring depth of submucosal invasion in T1 colorectal carcinomas
Authors: Yuta Kouyama
Shin-ei Kudo
Hideyuki Miyachi
Katsuro Ichimasa
Tomokazu Hisayuki
Hiromasa Oikawa
Shingo Matsudaira
Yui J. Kimura
Masashi Misawa
Yuichi Mori
Kenta Kodama
Toyoki Kudo
Takemasa Hayashi
Kunihiko Wakamura
Atsushi Katagiri
Eiji Hidaka
Fumio Ishida
Shigeharu Hamatani
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 1/2016
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-015-2403-7

At a glance: The STEP trials

Springer Medicine

Practical problems of measuring depth of submucosal invasion in T1 colorectal carcinomas

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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