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International Journal of Colorectal Disease

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01-12-2015 | Original Article

Anastomotic leakage after curative rectal cancer resection has no impact on long-term survival: a propensity score analysis

Authors: Sabrina M. Ebinger, René Warschkow, Ignazio Tarantino, Bruno M. Schmied, Lukas Marti

Published in: International Journal of Colorectal Disease | Issue 12/2015

Abstract

Purpose

Anastomotic leakage (AL) is a severe and frequent complication of rectal cancer resection, with an incidence rate of approximately 9 %. Although the impact of AL on morbidity and short-term mortality has been established, the literature is contradictory regarding its influence on long-term, cancer-specific survival. The present investigation assessed the long-term survival of 584 patients with stage I–III rectal cancer.

Methods

The 10-year overall survival and cancer-specific survival were analyzed in 584 patients from a single tertiary center. All patients had undergone curative rectal cancer resection between 1991 and 2010. Patients with and without AL were compared using both a multivariate Cox hazards model and propensity score analysis.

Results

A total of 64 patients developed AL (11.0 %, 95 % confidence interval (CI) = 8.7 to 13.8 %). The median follow-up was 5.2 years for all patients; and 7.4 years for patients still alive at the end of the investigated period. AL did persistently not impair cancer-specific survival based on unadjusted Cox regression (hazard ratio of death (HR) = 1.27, 95 % CI = 0.65 to 2.48, P = 0.489); risk-adjusted Cox regression (HR = 1.10, 95 % CI = 0.54 to 2.20, P = 0.799); and propensity score matching (HR = 1.18, 95 % CI = 0.57 to 2.43, P = 0.660).

Conclusions

Based on the present propensity score analysis, the oncologic outcomes in patients undergoing curative rectal cancer resections were not impaired by the development of anastomotic leakage.

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Title: Anastomotic leakage after curative rectal cancer resection has no impact on long-term survival: a propensity score analysis
Authors: Sabrina M. Ebinger
René Warschkow
Ignazio Tarantino
Bruno M. Schmied
Lukas Marti
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 12/2015
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-015-2331-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Anastomotic leakage after curative rectal cancer resection has no impact on long-term survival: a propensity score analysis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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