Skip to main content
Top
Published in: International Journal of Colorectal Disease 11/2015

01-11-2015 | Review

Conversion during laparoscopic colorectal resections: a complication or a drawback? A systematic review and meta-analysis of short-term outcomes

Authors: Mariano Cesare Giglio, Valerio Celentano, Rachele Tarquini, Gaetano Luglio, Giovanni Domenico De Palma, Luigi Bucci

Published in: International Journal of Colorectal Disease | Issue 11/2015

Login to get access

Abstract

Purpose

Several studies compared the outcomes of laparoscopically completed colorectal resections (LCR) to those requiring conversion to open surgery (COS). However, a comparative analysis between COS patients and patients undergoing planned open surgery (POS) would be useful to clarify if the conversion can be considered a simple drawback or a complication, being cause of additional postoperative morbidity. The aim of this study is to perform a meta-analysis of current evidences comparing postoperative outcomes of COS patients to POS patients.

Methods

A systematic search of Medline, ISI Web of Knowledge, and Scopus was performed to identify studies reporting short-term outcomes of COS and POS patients. Primary outcomes were 30-day overall morbidity and length of postoperative hospital stay. Data were analyzed with fixed-effect modeling, and sensitivity analyses were performed to test the robustness of the results.

Results

Twenty studies involving 30,656 patients undergoing POS and 1935 COS patients were selected. The mean conversion rate was 0.17. Similar 30-day overall morbidity and length of postoperative hospital stay were found in COS and POS patients. Wound infection (OR 1.43, 95 % CI 1.12 to 1.83, p < 0.01) was higher in the COS group. Other results were robust. Outcomes were comparable for patients undergoing resection for different natures of the disease (benign vs. malignant) and at different sites (colon vs. rectum).

Conclusion

Conversions from laparoscopic to open procedure during colorectal resection are not associated with a poorer postoperative outcome compared to patients undergoing planned open surgery, except for a higher risk of wound infection.
Appendix
Available only for authorised users
Literature
2.
go back to reference Schwandner O, Schiedeck TH, Bruch H (1999) The role of conversion in laparoscopic colorectal surgery: do predictive factors exist? Surg Endosc 13:151–156CrossRefPubMed Schwandner O, Schiedeck TH, Bruch H (1999) The role of conversion in laparoscopic colorectal surgery: do predictive factors exist? Surg Endosc 13:151–156CrossRefPubMed
3.
go back to reference Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, Heath RM, Brown JM (2005) Short term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 365:1718–1726, doi:1010.1016/S0140-6736(05)66545-2 Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, Heath RM, Brown JM (2005) Short term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 365:1718–1726, doi:1010.​1016/​S0140-6736(05)66545-2
4.
go back to reference Neudecker J, Klein F, Bittner R, Carus T, Stroux A, Schwenk W (2009) Short-term outcomes from a prospective randomized trial comparing laparoscopic and open surgery for colorectal cancer. Br J Surg 96:1458–1467. doi:10.1002/bjs.6782 CrossRefPubMed Neudecker J, Klein F, Bittner R, Carus T, Stroux A, Schwenk W (2009) Short-term outcomes from a prospective randomized trial comparing laparoscopic and open surgery for colorectal cancer. Br J Surg 96:1458–1467. doi:10.​1002/​bjs.​6782 CrossRefPubMed
5.
go back to reference Veldkamp R, Kuhry E, Hop WCJ, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Påhlman L, Cuesta MA, Msika S, Morino M, Lacy AM (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6:477–484, doi:10.1016/S1470-2045(05)70221-7 Veldkamp R, Kuhry E, Hop WCJ, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Påhlman L, Cuesta MA, Msika S, Morino M, Lacy AM (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6:477–484, doi:10.​1016/​S1470-2045(05)70221-7
6.
go back to reference Van der Pas MH, Haglind E, Cuesta MA, Fürst A, Lacy AM, Hop WC, Bonjer HJ (2013) Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol 14:210–218. doi:10.1016/S1470-2045(13)70016-0 CrossRefPubMed Van der Pas MH, Haglind E, Cuesta MA, Fürst A, Lacy AM, Hop WC, Bonjer HJ (2013) Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol 14:210–218. doi:10.​1016/​S1470-2045(13)70016-0 CrossRefPubMed
8.
go back to reference Marusch F, Gastinger I, Schneider C, Scheidbach H, Konradt J, Bruch HP, Köhler L, Bärlehner E, Köckerling F (2001) Importance of conversion for results obtained with laparoscopic colorectal surgery. Dis Colon Rectum 44:207–214, discussion 214–6CrossRefPubMed Marusch F, Gastinger I, Schneider C, Scheidbach H, Konradt J, Bruch HP, Köhler L, Bärlehner E, Köckerling F (2001) Importance of conversion for results obtained with laparoscopic colorectal surgery. Dis Colon Rectum 44:207–214, discussion 214–6CrossRefPubMed
9.
go back to reference Lord SA, Larach SW, Ferrara A, Williamson PR, Lago CP, Lube MW (1996) Laparoscopic resections for colorectal carcinoma. A three-year experience. Dis Colon Rectum 39:148–154CrossRefPubMed Lord SA, Larach SW, Ferrara A, Williamson PR, Lago CP, Lube MW (1996) Laparoscopic resections for colorectal carcinoma. A three-year experience. Dis Colon Rectum 39:148–154CrossRefPubMed
10.
go back to reference Le Moine M-C, Fabre J-M, Vacher C, Navarro F, Picot M-C, Domergue J (2003) Factors and consequences of conversion in laparoscopic sigmoidectomy for diverticular disease. Br J Surg 90:232–236. doi:10.1002/bjs.4035 CrossRefPubMed Le Moine M-C, Fabre J-M, Vacher C, Navarro F, Picot M-C, Domergue J (2003) Factors and consequences of conversion in laparoscopic sigmoidectomy for diverticular disease. Br J Surg 90:232–236. doi:10.​1002/​bjs.​4035 CrossRefPubMed
12.
go back to reference Slim K, Pezet D, Riff Y, Clark E, Chipponi J (1995) High morbidity rate after converted laparoscopic colorectal surgery. Br J Surg 82:1406–1408CrossRefPubMed Slim K, Pezet D, Riff Y, Clark E, Chipponi J (1995) High morbidity rate after converted laparoscopic colorectal surgery. Br J Surg 82:1406–1408CrossRefPubMed
13.
go back to reference Ptok H, Kube R, Schmidt U, Köckerling F, Gastinger I, Lippert H (2009) Conversion from laparoscopic to open colonic cancer resection—associated factors and their influence on long-term oncological outcome. Eur J Surg Oncol 35:1273–1279. doi:10.1016/j.ejso.2009.06.006 CrossRefPubMed Ptok H, Kube R, Schmidt U, Köckerling F, Gastinger I, Lippert H (2009) Conversion from laparoscopic to open colonic cancer resection—associated factors and their influence on long-term oncological outcome. Eur J Surg Oncol 35:1273–1279. doi:10.​1016/​j.​ejso.​2009.​06.​006 CrossRefPubMed
14.
15.
17.
go back to reference Rottoli M, Bona S, Rosati R, Elmore U, Bianchi PP, Spinelli A, Bartolucci C, Montorsi M (2009) Laparoscopic rectal resection for cancer: effects of conversion on short-term outcome and survival. Ann Surg Oncol 16:1279–1286. doi:10.1245/s10434-009-0398-4 CrossRefPubMed Rottoli M, Bona S, Rosati R, Elmore U, Bianchi PP, Spinelli A, Bartolucci C, Montorsi M (2009) Laparoscopic rectal resection for cancer: effects of conversion on short-term outcome and survival. Ann Surg Oncol 16:1279–1286. doi:10.​1245/​s10434-009-0398-4 CrossRefPubMed
22.
go back to reference Curet MJ, Putrakul K, Pitcher DE, Josloff RK, Zucker KA (2000) Laparoscopically assisted colon resection for colon carcinoma perioperative results and long-term outcome. 1062–1066. doi:10.1007/s004640000092 Curet MJ, Putrakul K, Pitcher DE, Josloff RK, Zucker KA (2000) Laparoscopically assisted colon resection for colon carcinoma perioperative results and long-term outcome. 1062–1066. doi:10.​1007/​s004640000092
23.
go back to reference Senagore AJ, Luchtefeld MA, Mackeigan JM, Mazier WP, Lloyd LR, Hoffman JP (1993) Open colectomy versus laparoscopic colectomy—are there differences. Am Surg 59:549–554PubMed Senagore AJ, Luchtefeld MA, Mackeigan JM, Mazier WP, Lloyd LR, Hoffman JP (1993) Open colectomy versus laparoscopic colectomy—are there differences. Am Surg 59:549–554PubMed
24.
go back to reference Begos DG, Arsenault J, Ballantyne GH (1996) Laparoscopic colon and rectal surgery at a VA hospital. Analysis of the first 50 cases. Surg Endosc 10:1050–1056CrossRefPubMed Begos DG, Arsenault J, Ballantyne GH (1996) Laparoscopic colon and rectal surgery at a VA hospital. Analysis of the first 50 cases. Surg Endosc 10:1050–1056CrossRefPubMed
25.
go back to reference Bouvet M, Mansfield PF, Skibber JM, Curley SA, Ellis LM, Giacco GG, Madary AR, Ota DM, Feig BW (1998) Clinical, pathologic, and economic parameters of laparoscopic colon resection for cancer. Am J Surg 176:554–558CrossRefPubMed Bouvet M, Mansfield PF, Skibber JM, Curley SA, Ellis LM, Giacco GG, Madary AR, Ota DM, Feig BW (1998) Clinical, pathologic, and economic parameters of laparoscopic colon resection for cancer. Am J Surg 176:554–558CrossRefPubMed
27.
go back to reference Hewett PJ, Allardyce RA, Bagshaw PF, Frampton CM, Frizelle FA, Rieger NA, Smith JS, Solomon MJ, Stephens JH, Stevenson ARL (2008) Short-term outcomes of the Australasian randomized clinical study comparing laparoscopic and conventional open surgical treatments for colon cancer: the ALCCaS trial. Ann Surg 248:728–738. doi:10.1097/SLA.0b013e31818b7595 CrossRefPubMed Hewett PJ, Allardyce RA, Bagshaw PF, Frampton CM, Frizelle FA, Rieger NA, Smith JS, Solomon MJ, Stephens JH, Stevenson ARL (2008) Short-term outcomes of the Australasian randomized clinical study comparing laparoscopic and conventional open surgical treatments for colon cancer: the ALCCaS trial. Ann Surg 248:728–738. doi:10.​1097/​SLA.​0b013e31818b7595​ CrossRefPubMed
28.
go back to reference Martinek L, Dostalik J, Gunkova P, Gunka I, Vavra P, Zonca P (2012) Impact of conversion on outcome in laparoscopic colorectal cancer surgery. Videosurgery Other Miniinvasive Tech 7:74–81. doi:10.5114/wiitm.2011.25799 CrossRef Martinek L, Dostalik J, Gunkova P, Gunka I, Vavra P, Zonca P (2012) Impact of conversion on outcome in laparoscopic colorectal cancer surgery. Videosurgery Other Miniinvasive Tech 7:74–81. doi:10.​5114/​wiitm.​2011.​25799 CrossRef
31.
go back to reference Penninckx F, Kartheuser A, Van de Stadt J, Pattyn P, Mansvelt B, Bertrand C, Van Eycken E, Jegou D, Fieuws S (2013) Outcome following laparoscopic and open total mesorectal excision for rectal cancer. Br J Surg 100:1368–1375. doi:10.1002/bjs.9211 CrossRefPubMed Penninckx F, Kartheuser A, Van de Stadt J, Pattyn P, Mansvelt B, Bertrand C, Van Eycken E, Jegou D, Fieuws S (2013) Outcome following laparoscopic and open total mesorectal excision for rectal cancer. Br J Surg 100:1368–1375. doi:10.​1002/​bjs.​9211 CrossRefPubMed
32.
go back to reference Kang CY, Halabi WJ, Chaudhry OO, Nguyen V, Ketana N, Carmichael JC, Pigazzi A, Stamos MJ, Mills S (2013) A nationwide analysis of laparoscopy in high-risk colorectal surgery patients. J Gastrointest Surg 17:382–391. doi:10.1007/s11605-012-2096-y CrossRefPubMed Kang CY, Halabi WJ, Chaudhry OO, Nguyen V, Ketana N, Carmichael JC, Pigazzi A, Stamos MJ, Mills S (2013) A nationwide analysis of laparoscopy in high-risk colorectal surgery patients. J Gastrointest Surg 17:382–391. doi:10.​1007/​s11605-012-2096-y CrossRefPubMed
33.
go back to reference Kolfschoten NE, van Leersum NJ, Gooiker GA, Marang van de Mheen PJ, Eddes EH, Kievit J, Brand R, Tanis PJ, Bemelman WA, Tollenaar RA, Meijerink J, Wouters MW (2013) Successful and safe introduction of laparoscopic colorectal cancer surgery in Dutch hospitals. Ann Surg 257:916–921. doi:10.1097/SLA.0b013e31825d0f37 CrossRefPubMed Kolfschoten NE, van Leersum NJ, Gooiker GA, Marang van de Mheen PJ, Eddes EH, Kievit J, Brand R, Tanis PJ, Bemelman WA, Tollenaar RA, Meijerink J, Wouters MW (2013) Successful and safe introduction of laparoscopic colorectal cancer surgery in Dutch hospitals. Ann Surg 257:916–921. doi:10.​1097/​SLA.​0b013e31825d0f37​ CrossRefPubMed
34.
go back to reference Rickert A, Herrle F, Doyon F, Post S, Kienle P (2013) Influence of conversion on the perioperative and oncologic outcomes of laparoscopic resection for rectal cancer compared with primarily open resection. Surg Endosc 27:4675–4683. doi:10.1007/s00464-013-3108-z CrossRefPubMed Rickert A, Herrle F, Doyon F, Post S, Kienle P (2013) Influence of conversion on the perioperative and oncologic outcomes of laparoscopic resection for rectal cancer compared with primarily open resection. Surg Endosc 27:4675–4683. doi:10.​1007/​s00464-013-3108-z CrossRefPubMed
36.
go back to reference Koo H, Kim H, Yun S, Lee W, Cho Y, Park Y, Yun J, Kim K (2013) Comparison of short-term and long-term outcomes in open surgery group, laparoscopic surgery group and conversion to open surgery group during laparoscopic colorectal cancer surgery. Dis Colon Rectum 56:E272 Koo H, Kim H, Yun S, Lee W, Cho Y, Park Y, Yun J, Kim K (2013) Comparison of short-term and long-term outcomes in open surgery group, laparoscopic surgery group and conversion to open surgery group during laparoscopic colorectal cancer surgery. Dis Colon Rectum 56:E272
37.
go back to reference Jayne DG, Thorpe HC, Copeland J, Quirke P, Brown JM, Guillou PJ (2010) Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. Br J Surg 97:1638–1645. doi:10.1002/bjs.7160 CrossRefPubMed Jayne DG, Thorpe HC, Copeland J, Quirke P, Brown JM, Guillou PJ (2010) Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. Br J Surg 97:1638–1645. doi:10.​1002/​bjs.​7160 CrossRefPubMed
38.
go back to reference Bhama AR, Charlton ME, Schmitt MB, Cromwell JW, Byrn JC (2014) Factors associated with conversion from laparoscopic to open colectomy using the National Surgical Quality Improvement Program (NSQIP) database. Color Dis. doi:10.1111/codi.12800 Bhama AR, Charlton ME, Schmitt MB, Cromwell JW, Byrn JC (2014) Factors associated with conversion from laparoscopic to open colectomy using the National Surgical Quality Improvement Program (NSQIP) database. Color Dis. doi:10.​1111/​codi.​12800
39.
go back to reference Masoomi H, Moghadamyeghaneh Z, Mills S, Carmichael JC, Pigazzi A, Stamos MJ (2015) Risk factors for conversion of laparoscopic colorectal surgery to open surgery: does conversion worsen outcome? World J Surg. doi:10.1007/s00268-015-2958-z PubMed Masoomi H, Moghadamyeghaneh Z, Mills S, Carmichael JC, Pigazzi A, Stamos MJ (2015) Risk factors for conversion of laparoscopic colorectal surgery to open surgery: does conversion worsen outcome? World J Surg. doi:10.​1007/​s00268-015-2958-z PubMed
40.
go back to reference Cima RR, Hassan I, Poola VP, Larson DW, Dozois EJ, Larson DR, O’Byrne MM, Huebner M (2010) Failure of institutionally derived predictive models of conversion in laparoscopic colorectal surgery to predict conversion outcomes in an independent data set of 998 laparoscopic colorectal procedures. Ann Surg 251:652–658. doi:10.1097/SLA.0b013e3181d355f7 CrossRefPubMed Cima RR, Hassan I, Poola VP, Larson DW, Dozois EJ, Larson DR, O’Byrne MM, Huebner M (2010) Failure of institutionally derived predictive models of conversion in laparoscopic colorectal surgery to predict conversion outcomes in an independent data set of 998 laparoscopic colorectal procedures. Ann Surg 251:652–658. doi:10.​1097/​SLA.​0b013e3181d355f7​ CrossRefPubMed
Metadata
Title
Conversion during laparoscopic colorectal resections: a complication or a drawback? A systematic review and meta-analysis of short-term outcomes
Authors
Mariano Cesare Giglio
Valerio Celentano
Rachele Tarquini
Gaetano Luglio
Giovanni Domenico De Palma
Luigi Bucci
Publication date
01-11-2015
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 11/2015
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-015-2324-5

Other articles of this Issue 11/2015

International Journal of Colorectal Disease 11/2015 Go to the issue