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Published in: International Journal of Colorectal Disease 2/2015

01-02-2015 | Original Article

Long-term outcome of low perianal fistulas treated by fistulotomy: a multicenter study

Authors: K. W. A. Göttgens, P. T. J. Janssen, J. Heemskerk, F. M. H. van Dielen, J. L. M. Konsten, T. Lettinga, A. G. M. Hoofwijk, H. J. Belgers, L. P. S. Stassen, S. O. Breukink

Published in: International Journal of Colorectal Disease | Issue 2/2015

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Abstract

Purpose

Fistulotomy is considered to be the golden standard for the treatment of low perianal fistula but might have more influence on continence status than believed. This study was performed to evaluate the healing rate after a fistulotomy and to show results for continence status.

Methods

A retrospective database study was performed in one university medical center and its six affiliated hospitals. All patients treated with a fistulotomy for a low perianal fistula were identified. Healing and recurrence of the fistula were identified. Questionnaires on continence status and quality of life were mailed to all patients.

Results

In total, 537 patients were identified. The primary etiology of the fistulas was cryptoglandular (66.5 %). Recurrence was seen in 88 patients (16.4 %) resulting in a primary healing rate of 83.6 %. After secondary treatment for the recurrence, another 40 patients healed. This resulted in a secondary healing rate of 90.3 %. The Kaplan-Meier analysis showed that at 5 years, the healing rate was 0.81 (95 % confidence interval (95 % CI) 0.71–0.85). The mean Vaizey score was 4.67 (SD 4.80). Major incontinence, defined as a Vaizey score of >6, was seen in 95 (28.0 %) patients. Only 26.3 % of the patients had a perfect continence status (Vaizey score 0). Quality of life was not different from the general population.

Conclusions

Fistulotomy seems to be associated with a healing rate of 0.81 (95 % CI 0.71–0.85) after 5 years. However, major incontinence is still reported by 26.8 % of patients and only 26.3 % of patients had a perfect continence status.
Literature
1.
2.
go back to reference Garcia-Aguilar J, Belmonte C, Wong WD, Goldberg SM, Madoff RD (1996) Anal fistula surgery. Factors associated with recurrence and incontinence. Dis Colon Rectum 39:723–729PubMedCrossRef Garcia-Aguilar J, Belmonte C, Wong WD, Goldberg SM, Madoff RD (1996) Anal fistula surgery. Factors associated with recurrence and incontinence. Dis Colon Rectum 39:723–729PubMedCrossRef
3.
go back to reference Dubsky PC, Stift A, Friedl J, Teleky B, Herbst F (2008) Endorectal advancement flaps in the treatment of high anal fistula of cryptoglandular origin: full-thickness vs. mucosal-rectum flaps. Dis Colon Rectum 51:852–857. doi:10.1007/s10350-008-9242-3 PubMedCrossRef Dubsky PC, Stift A, Friedl J, Teleky B, Herbst F (2008) Endorectal advancement flaps in the treatment of high anal fistula of cryptoglandular origin: full-thickness vs. mucosal-rectum flaps. Dis Colon Rectum 51:852–857. doi:10.​1007/​s10350-008-9242-3 PubMedCrossRef
4.
go back to reference Champagne BJ, O’Connor LM, Ferguson M, Orangio GR, Schertzer ME, Armstrong DN (2006) Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. Dis Colon Rectum 49:1817–1821. doi:10.1007/s10350-006-0755-3 PubMedCrossRef Champagne BJ, O’Connor LM, Ferguson M, Orangio GR, Schertzer ME, Armstrong DN (2006) Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. Dis Colon Rectum 49:1817–1821. doi:10.​1007/​s10350-006-0755-3 PubMedCrossRef
5.
6.
go back to reference Rojanasakul A, Pattanaarun J, Sahakitrungruang C, Tantiphlachiva K (2007) Total anal sphincter saving technique for fistula-in-ano; the ligation of intersphincteric fistula tract. J Med Assoc Thail 90:581–586 Rojanasakul A, Pattanaarun J, Sahakitrungruang C, Tantiphlachiva K (2007) Total anal sphincter saving technique for fistula-in-ano; the ligation of intersphincteric fistula tract. J Med Assoc Thail 90:581–586
7.
go back to reference Gottgens KW, Vening W, Van Der Hagen SJ, Van Gemert WG, Smeets RR, Stassen LP, Baeten CG, Breukink SO (2014) Long-term results of mucosal advancement flap combined with platelet-rich plasma for high cryptoglandular perianal fistulas. Dis Colon Rectum 57:223–227. doi:10.1097/DCR.0000000000000023 PubMedCrossRef Gottgens KW, Vening W, Van Der Hagen SJ, Van Gemert WG, Smeets RR, Stassen LP, Baeten CG, Breukink SO (2014) Long-term results of mucosal advancement flap combined with platelet-rich plasma for high cryptoglandular perianal fistulas. Dis Colon Rectum 57:223–227. doi:10.​1097/​DCR.​0000000000000023​ PubMedCrossRef
8.
go back to reference Herreros MD, Garcia-Arranz M, Guadalajara H, De-La-Quintana P, Garcia-Olmo D (2012) Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: Fistula Advanced Therapy Trial 1) and long-term evaluation. Dis Colon Rectum 55:762–772. doi:10.1097/DCR.0b013e318255364a PubMedCrossRef Herreros MD, Garcia-Arranz M, Guadalajara H, De-La-Quintana P, Garcia-Olmo D (2012) Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: Fistula Advanced Therapy Trial 1) and long-term evaluation. Dis Colon Rectum 55:762–772. doi:10.​1097/​DCR.​0b013e318255364a​ PubMedCrossRef
9.
10.
go back to reference Van Der Hagen SJ, Baeten CG, Soeters PB, Van Gemert WG (2006) Long-term outcome following mucosal advancement flap for high perianal fistulas and fistulotomy for low perianal fistulas: recurrent perianal fistulas: failure of treatment or recurrent patient disease? Int J Colorectal Dis 21:784–790. doi:10.1007/s00384-005-0072-7 PubMedCrossRef Van Der Hagen SJ, Baeten CG, Soeters PB, Van Gemert WG (2006) Long-term outcome following mucosal advancement flap for high perianal fistulas and fistulotomy for low perianal fistulas: recurrent perianal fistulas: failure of treatment or recurrent patient disease? Int J Colorectal Dis 21:784–790. doi:10.​1007/​s00384-005-0072-7 PubMedCrossRef
11.
go back to reference Van Koperen PJ, Wind J, Bemelman WA, Bakx R, Reitsma JB, Slors JF (2008) Long-term functional outcome and risk factors for recurrence after surgical treatment for low and high perianal fistulas of cryptoglandular origin. Dis Colon Rectum 51:1475–1481. doi:10.1007/s10350-008-9354-9 PubMedCrossRef Van Koperen PJ, Wind J, Bemelman WA, Bakx R, Reitsma JB, Slors JF (2008) Long-term functional outcome and risk factors for recurrence after surgical treatment for low and high perianal fistulas of cryptoglandular origin. Dis Colon Rectum 51:1475–1481. doi:10.​1007/​s10350-008-9354-9 PubMedCrossRef
14.
go back to reference Westerterp M, Volkers NA, Poolman RW, Van Tets WF (2003) Anal fistulotomy between Skylla and Charybdis. Colorectal Dis 5:549–551PubMedCrossRef Westerterp M, Volkers NA, Poolman RW, Van Tets WF (2003) Anal fistulotomy between Skylla and Charybdis. Colorectal Dis 5:549–551PubMedCrossRef
15.
go back to reference Van Onkelen RS, Gosselink MP, Schouten WR (2012) Ligation of the intersphincteric fistula tract in low transsphincteric fistula: a new technique to avoid fistulotomy. Colorectal Dis. doi:10.1111/codi.12030 Van Onkelen RS, Gosselink MP, Schouten WR (2012) Ligation of the intersphincteric fistula tract in low transsphincteric fistula: a new technique to avoid fistulotomy. Colorectal Dis. doi:10.​1111/​codi.​12030
18.
go back to reference Ware JE Jr, Snow KK, Kosinski M, Gandek B (1993) SF-36 Health Survey manual and interpretation guide. New England Medical Centre, The Health Institute, Boston Ware JE Jr, Snow KK, Kosinski M, Gandek B (1993) SF-36 Health Survey manual and interpretation guide. New England Medical Centre, The Health Institute, Boston
19.
go back to reference Aaronson NK, Muller M, Cohen PD, Essink-Bot ML, Fekkes M, Sanderman R, Sprangers MA, Te Velde A, Verrips E (1998) Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations. J Clin Epidemiol 51:1055–1068PubMedCrossRef Aaronson NK, Muller M, Cohen PD, Essink-Bot ML, Fekkes M, Sanderman R, Sprangers MA, Te Velde A, Verrips E (1998) Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations. J Clin Epidemiol 51:1055–1068PubMedCrossRef
20.
21.
go back to reference Malouf AJ, Buchanan GN, Carapeti EA, Rao S, Guy RJ, Westcott E, Thomson JP, Cohen CR (2002) A prospective audit of fistula-in-ano at St. Mark’s Hospital. Colorectal Dis 4:13–19PubMedCrossRef Malouf AJ, Buchanan GN, Carapeti EA, Rao S, Guy RJ, Westcott E, Thomson JP, Cohen CR (2002) A prospective audit of fistula-in-ano at St. Mark’s Hospital. Colorectal Dis 4:13–19PubMedCrossRef
22.
go back to reference Vasilevsky CA, Gordon PH (1985) Results of treatment of fistula-in-ano. Dis Colon Rectum 28:225–231PubMedCrossRef Vasilevsky CA, Gordon PH (1985) Results of treatment of fistula-in-ano. Dis Colon Rectum 28:225–231PubMedCrossRef
23.
go back to reference Van Tets WF, Kuijpers HC (1994) Continence disorders after anal fistulotomy. Dis Colon Rectum 37:1194–1197PubMedCrossRef Van Tets WF, Kuijpers HC (1994) Continence disorders after anal fistulotomy. Dis Colon Rectum 37:1194–1197PubMedCrossRef
25.
go back to reference Sileri P, Cadeddu F, D’Ugo S, Franceschilli L, Del Vecchio Blanco G, De Luca E, Calabrese E, Capperucci SM, Fiaschetti V, Milito G, Gaspari AL (2011) Surgery for fistula-in-ano in a specialist colorectal unit: a critical appraisal. BMC Gastroenterol 11:120. doi:10.1186/1471-230X-11-120 PubMedCentralPubMedCrossRef Sileri P, Cadeddu F, D’Ugo S, Franceschilli L, Del Vecchio Blanco G, De Luca E, Calabrese E, Capperucci SM, Fiaschetti V, Milito G, Gaspari AL (2011) Surgery for fistula-in-ano in a specialist colorectal unit: a critical appraisal. BMC Gastroenterol 11:120. doi:10.​1186/​1471-230X-11-120 PubMedCentralPubMedCrossRef
26.
go back to reference Aaronson NK (1989) Quality of life assessment in clinical trials: methodologic issues. Control Clin Trials 10:195S–208SPubMedCrossRef Aaronson NK (1989) Quality of life assessment in clinical trials: methodologic issues. Control Clin Trials 10:195S–208SPubMedCrossRef
27.
go back to reference Kinsella JB, Rassekh CH, Wassmuth ZD, Hokanson JA, Calhoun KH (1999) Smoking increases facial skin flap complications. Ann Otol Rhinol Laryngol 108:139–142PubMedCrossRef Kinsella JB, Rassekh CH, Wassmuth ZD, Hokanson JA, Calhoun KH (1999) Smoking increases facial skin flap complications. Ann Otol Rhinol Laryngol 108:139–142PubMedCrossRef
28.
go back to reference Zimmerman DD, Delemarre JB, Gosselink MP, Hop WC, Briel JW, Schouten WR (2003) Smoking affects the outcome of transanal mucosal advancement flap repair of trans-sphincteric fistulas. Br J Surg 90:351–354. doi:10.1002/bjs.4044 PubMedCrossRef Zimmerman DD, Delemarre JB, Gosselink MP, Hop WC, Briel JW, Schouten WR (2003) Smoking affects the outcome of transanal mucosal advancement flap repair of trans-sphincteric fistulas. Br J Surg 90:351–354. doi:10.​1002/​bjs.​4044 PubMedCrossRef
Metadata
Title
Long-term outcome of low perianal fistulas treated by fistulotomy: a multicenter study
Authors
K. W. A. Göttgens
P. T. J. Janssen
J. Heemskerk
F. M. H. van Dielen
J. L. M. Konsten
T. Lettinga
A. G. M. Hoofwijk
H. J. Belgers
L. P. S. Stassen
S. O. Breukink
Publication date
01-02-2015
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 2/2015
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-014-2072-y

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