Skip to main content
Top
Published in: International Journal of Colorectal Disease 4/2013

01-04-2013 | Review

Systematic review on the value of CT scanning in the diagnosis of anastomotic leakage after colorectal surgery

Authors: Verena N. N. Kornmann, Nikki Treskes, Lilian H. F. Hoonhout, Thomas L. Bollen, Bert van Ramshorst, Djamila Boerma

Published in: International Journal of Colorectal Disease | Issue 4/2013

Login to get access

Abstract

Background

Timely diagnosis of anastomotic leakage after colorectal surgery and adequate treatment is important to reduce morbidity and mortality. Abdominal computed tomography (CT) scanning is the diagnostic tool of preference, but its value may be questionable in the early postoperative period. The accuracy of CT scanning for the detection of anastomotic leakage and its role in timing of intervention was evaluated.

Methods

A systematic literature search was performed. Relevant publications were identified from four electronic databases between 1990 and 2011. Inclusion criteria were human studies, studies published in English or Dutch, colorectal surgery with primary anastomosis, and abdominal CT scan with reported outcome for the detection of anastomotic leakage. Exclusion criteria were cohort of fewer than five patients, other gastrointestinal surgery, no anastomosis, and radiological imaging other than CT.

Results

Eight studies, including 221 abdominal CT scans, fulfilled the inclusion criteria. Overall, the methodological quality of the studies was poor. The overall sensitivity of CT scanning to diagnose leakage was 0.68 (95 % confidence interval 0.59–0.75) for colonic resection. Data on the sequelae of false-negative CT scanning was not available.

Conclusion

There is limited good-quality evidence to determine the value of CT scans in the detection of anastomotic leakage. To prevent delay in diagnosis and appropriate treatment of anastomotic leakage, the relatively low sensitivity of CT scanning must be taken into account.
Literature
1.
go back to reference Bokey EL, Chapuis PH, Fung C et al (1995) Postoperative morbidity and mortality following resection of the colon and rectum for cancer. Dis Colon Rectum 38:480–486PubMedCrossRef Bokey EL, Chapuis PH, Fung C et al (1995) Postoperative morbidity and mortality following resection of the colon and rectum for cancer. Dis Colon Rectum 38:480–486PubMedCrossRef
2.
go back to reference Buchs NC, Gervaz P, Secic M et al (2007) Incidence, consequences, and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study. Int J Colorectal Dis 23:265–270PubMedCrossRef Buchs NC, Gervaz P, Secic M et al (2007) Incidence, consequences, and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study. Int J Colorectal Dis 23:265–270PubMedCrossRef
3.
go back to reference Komen N, Dijk JW, Lalmahomed Z et al (2009) After-hours colorectal surgery: a risk factor for anastomotic leakage. Int J Colorectal Dis 24:789–795PubMedCrossRef Komen N, Dijk JW, Lalmahomed Z et al (2009) After-hours colorectal surgery: a risk factor for anastomotic leakage. Int J Colorectal Dis 24:789–795PubMedCrossRef
4.
go back to reference Matthiessen P, Hallböök O, Andersson M et al (2004) Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis 6:464–469CrossRef Matthiessen P, Hallböök O, Andersson M et al (2004) Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis 6:464–469CrossRef
5.
go back to reference Kruschewski M, Rieger H, Pohlen U et al (2007) Risk factors for clinical anastomotic leakage and postoperative mortality in elective surgery for rectal cancer. Int J Colorectal Dis 22:919–927PubMedCrossRef Kruschewski M, Rieger H, Pohlen U et al (2007) Risk factors for clinical anastomotic leakage and postoperative mortality in elective surgery for rectal cancer. Int J Colorectal Dis 22:919–927PubMedCrossRef
6.
go back to reference Alves A, Panis Y, Pocard M et al (1999) Management of anastomotic leakage after nondiverted large bowel resection. J Am Coll Surg 189(6):554–559PubMedCrossRef Alves A, Panis Y, Pocard M et al (1999) Management of anastomotic leakage after nondiverted large bowel resection. J Am Coll Surg 189(6):554–559PubMedCrossRef
7.
go back to reference Veyrie N, Ata T, Muscari F et al (2007) Anastomotic leakage after elective right versus left colectomy for cancer: prevalence and independent risk factors. J Am Coll Surg 205:785–793PubMedCrossRef Veyrie N, Ata T, Muscari F et al (2007) Anastomotic leakage after elective right versus left colectomy for cancer: prevalence and independent risk factors. J Am Coll Surg 205:785–793PubMedCrossRef
8.
go back to reference Marra F, Steffen T, Kalak N et al (2009) Anastomotic leakage as a risk factor for the long-term outcome after curative resection of colon cancer. EJSO 35:1060–1064PubMedCrossRef Marra F, Steffen T, Kalak N et al (2009) Anastomotic leakage as a risk factor for the long-term outcome after curative resection of colon cancer. EJSO 35:1060–1064PubMedCrossRef
9.
go back to reference den Dulk M, Noter SL, Hendriks ER et al (2009) Improved diagnosis and treatment of anastomotic leakage after colorectal surgery. EJSO 35:420–426CrossRef den Dulk M, Noter SL, Hendriks ER et al (2009) Improved diagnosis and treatment of anastomotic leakage after colorectal surgery. EJSO 35:420–426CrossRef
10.
go back to reference Platell C, Barwood N, Dorfmann G et al (2007) The incidence of anastomotic leaks in patients undergoing colorectal surgery. Colorectal Dis 9:71–79PubMedCrossRef Platell C, Barwood N, Dorfmann G et al (2007) The incidence of anastomotic leaks in patients undergoing colorectal surgery. Colorectal Dis 9:71–79PubMedCrossRef
11.
go back to reference Sørensen LT, Jørgensen T, Kirkeby LT et al (1999) Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg 86:927–931PubMedCrossRef Sørensen LT, Jørgensen T, Kirkeby LT et al (1999) Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg 86:927–931PubMedCrossRef
12.
go back to reference Konishi T, Watanabe T, Kishimoto J et al (2006) Risk factors for anastomotic leakage after surgery for colorectal cancer: results of prospective surveillance. J Am Coll Surg 202:439–444PubMedCrossRef Konishi T, Watanabe T, Kishimoto J et al (2006) Risk factors for anastomotic leakage after surgery for colorectal cancer: results of prospective surveillance. J Am Coll Surg 202:439–444PubMedCrossRef
13.
go back to reference Choi HK, Law WL, Ho JW (2006) Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors. Dis Colon Rectum 49:1719–1725PubMedCrossRef Choi HK, Law WL, Ho JW (2006) Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors. Dis Colon Rectum 49:1719–1725PubMedCrossRef
14.
go back to reference Makela JT, Kiviniemi H, Laitinen S (2003) Risk factors for anastomotic leakage after left-sided colorectal resection with rectal anastomosis. Dis Colon Rectum 46:653–660PubMedCrossRef Makela JT, Kiviniemi H, Laitinen S (2003) Risk factors for anastomotic leakage after left-sided colorectal resection with rectal anastomosis. Dis Colon Rectum 46:653–660PubMedCrossRef
15.
go back to reference Fawcett A, Shembekar M, Church JS et al (1996) Smoking, hypertension, and colonic anastomotic healing; a combined clinical and histopathological study. Gut 38:714–718PubMedCrossRef Fawcett A, Shembekar M, Church JS et al (1996) Smoking, hypertension, and colonic anastomotic healing; a combined clinical and histopathological study. Gut 38:714–718PubMedCrossRef
16.
go back to reference Hyman N, Manchester TL, Osler T et al (2007) Anastomotic leaks after intestinal anastomosis: it’s later than you think. Ann Surg 245:254–258PubMedCrossRef Hyman N, Manchester TL, Osler T et al (2007) Anastomotic leaks after intestinal anastomosis: it’s later than you think. Ann Surg 245:254–258PubMedCrossRef
17.
go back to reference Matheson NA, McIntosh CA, Krukowski ZH (1985) Continuing experience with single layer appositional anastomosis in the large bowel. Br J Surg 72:S104–S106PubMedCrossRef Matheson NA, McIntosh CA, Krukowski ZH (1985) Continuing experience with single layer appositional anastomosis in the large bowel. Br J Surg 72:S104–S106PubMedCrossRef
18.
go back to reference Matthiessen P, Henriksson M, Hallböök O et al (2007) Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial. Ann Surg 246:207–214PubMedCrossRef Matthiessen P, Henriksson M, Hallböök O et al (2007) Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial. Ann Surg 246:207–214PubMedCrossRef
19.
go back to reference Merad F, Hay JM, Fingerhut A et al (1998) Omentoplasty in the prevention of anastomotic leakage after colonic or rectal resection: a prospective randomized study in 712 patients. French associations for surgical research. Ann Surg 227:179–186PubMedCrossRef Merad F, Hay JM, Fingerhut A et al (1998) Omentoplasty in the prevention of anastomotic leakage after colonic or rectal resection: a prospective randomized study in 712 patients. French associations for surgical research. Ann Surg 227:179–186PubMedCrossRef
20.
go back to reference Tuson JR, Everett WG (1990) A retrospective study of colostomies, leaks and strictures after colorectal anastomosis. Int J Colorectal Dis 5:44–548PubMedCrossRef Tuson JR, Everett WG (1990) A retrospective study of colostomies, leaks and strictures after colorectal anastomosis. Int J Colorectal Dis 5:44–548PubMedCrossRef
21.
go back to reference Kanellos I, Blouhos K, Demetriades H (2004) The failed intraperitoneal colon anastomosis after colon resection. Tech Coloprotocol 8:S53–S55CrossRef Kanellos I, Blouhos K, Demetriades H (2004) The failed intraperitoneal colon anastomosis after colon resection. Tech Coloprotocol 8:S53–S55CrossRef
22.
go back to reference Scardapane A, Brindicci D, Fracella MR et al (2005) Post colon surgery complications: imaging findings. Eur J Radiol 53:397–409PubMedCrossRef Scardapane A, Brindicci D, Fracella MR et al (2005) Post colon surgery complications: imaging findings. Eur J Radiol 53:397–409PubMedCrossRef
23.
go back to reference Nesbakken A, Nygaard K, Lunde OC et al (2005) Anastomotic leak following mesorectal excision for rectal cancer: true incidence and diagnostic challenges. Colorectal Dis 7(6):576–581PubMedCrossRef Nesbakken A, Nygaard K, Lunde OC et al (2005) Anastomotic leak following mesorectal excision for rectal cancer: true incidence and diagnostic challenges. Colorectal Dis 7(6):576–581PubMedCrossRef
24.
go back to reference Nicksa GA, Dring RV, Johnson KH et al (2007) Anastomotic leaks: what is the best diagnostic imaging study? Dis Colon Rectum 50:197–203PubMedCrossRef Nicksa GA, Dring RV, Johnson KH et al (2007) Anastomotic leaks: what is the best diagnostic imaging study? Dis Colon Rectum 50:197–203PubMedCrossRef
25.
go back to reference Lim M, Akhtar S, Sasapu K et al (2006) Clinical and subclinical leaks after low colorectal anastomosis: a clinical and radiologic study. Dis Colon Rectum 49:1611–1619PubMedCrossRef Lim M, Akhtar S, Sasapu K et al (2006) Clinical and subclinical leaks after low colorectal anastomosis: a clinical and radiologic study. Dis Colon Rectum 49:1611–1619PubMedCrossRef
26.
go back to reference Bruce J, Krukowski ZH, Al-Khairy G et al (2001) Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br J Surg 88:1157–1168PubMedCrossRef Bruce J, Krukowski ZH, Al-Khairy G et al (2001) Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br J Surg 88:1157–1168PubMedCrossRef
27.
go back to reference Eckmann C, Kujath P, Schiedeck THK et al (2004) Anastomotic leakage following low anterior resection: results of a standardized diagnostic and therapeutic approach. Int J Colorectal Dis 19(2):128–133PubMedCrossRef Eckmann C, Kujath P, Schiedeck THK et al (2004) Anastomotic leakage following low anterior resection: results of a standardized diagnostic and therapeutic approach. Int J Colorectal Dis 19(2):128–133PubMedCrossRef
28.
go back to reference Khoury W, Ben-Yehuda A, Ben-Haim M et al (2009) Abdominal computed tomography for diagnosing postoperative lower gastrointestinal tract leaks. J Gastrointest Surg 13:1454–1458PubMedCrossRef Khoury W, Ben-Yehuda A, Ben-Haim M et al (2009) Abdominal computed tomography for diagnosing postoperative lower gastrointestinal tract leaks. J Gastrointest Surg 13:1454–1458PubMedCrossRef
29.
go back to reference Higgins JPT, Green S (editors). Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org. Higgins JPT, Green S (editors). Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.​cochrane-handbook.​org.
30.
go back to reference Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PloS Med 6:1–27CrossRef Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PloS Med 6:1–27CrossRef
32.
go back to reference Komen N, Klitsie P, Dijk JW et al (2011) Calcium score: a new risk factor for colorectal anastomotic leakage. Am J Surgery 201:759–765CrossRef Komen N, Klitsie P, Dijk JW et al (2011) Calcium score: a new risk factor for colorectal anastomotic leakage. Am J Surgery 201:759–765CrossRef
33.
go back to reference Maggard MA, Jesse MD, Thompson JE et al (1999) Same admission colon resection with primary anastomosis for acute diverticulitis. Am Surg 65(10):927–930PubMed Maggard MA, Jesse MD, Thompson JE et al (1999) Same admission colon resection with primary anastomosis for acute diverticulitis. Am Surg 65(10):927–930PubMed
34.
go back to reference Doeksen A, Tanis PJ, Vrouenraets BC et al (2007) Factors determining delay in relaparotomy for anastomotic leakage after colorectal resection. World J Gastro-enterol 13:3721–3725 Doeksen A, Tanis PJ, Vrouenraets BC et al (2007) Factors determining delay in relaparotomy for anastomotic leakage after colorectal resection. World J Gastro-enterol 13:3721–3725
35.
go back to reference Matthiessen P, Henriksson M, Hallböök O (2007) Increase of serum C-reactive protein is an early indicator of subsequent symptomatic anastomotic leakage after anterior resection. Colorectal Dis 10:75–80PubMed Matthiessen P, Henriksson M, Hallböök O (2007) Increase of serum C-reactive protein is an early indicator of subsequent symptomatic anastomotic leakage after anterior resection. Colorectal Dis 10:75–80PubMed
36.
go back to reference Power N, Atri M, Ryan S et al (2007) CT assessment of anastomotic bowel leak. Clin Radiol 62(1):37–42PubMedCrossRef Power N, Atri M, Ryan S et al (2007) CT assessment of anastomotic bowel leak. Clin Radiol 62(1):37–42PubMedCrossRef
37.
go back to reference Crema MD, Richarme D, Azizi L et al (2006) Pouchography, CT, and MRI features of ileal J pouch-anal anastomosis. Am J Roentgenol 187(6):W594–W603CrossRef Crema MD, Richarme D, Azizi L et al (2006) Pouchography, CT, and MRI features of ileal J pouch-anal anastomosis. Am J Roentgenol 187(6):W594–W603CrossRef
38.
go back to reference Garcea F, Majid I, Sutton CD et al (2006) Diagnosis and management of colovesical fistulae: six-year experience of 90 cases. Colorectal Dis 8(4):347–352PubMedCrossRef Garcea F, Majid I, Sutton CD et al (2006) Diagnosis and management of colovesical fistulae: six-year experience of 90 cases. Colorectal Dis 8(4):347–352PubMedCrossRef
39.
go back to reference Tian Yue K, Pin Lin K, Goh Soon Whatt A (2010) Imaging postoperative bile leaks and assessing integrity of biliary-enteric anastomoses with fusion HIDE SEPCT/CT scintigraphy. Clin Nucl Med 35(11):875–878PubMedCrossRef Tian Yue K, Pin Lin K, Goh Soon Whatt A (2010) Imaging postoperative bile leaks and assessing integrity of biliary-enteric anastomoses with fusion HIDE SEPCT/CT scintigraphy. Clin Nucl Med 35(11):875–878PubMedCrossRef
40.
go back to reference Doeksen A, Tanis PJ, Wüst AFJ et al (2008) Radiological evaluation of colorectal anastomoses. Int J Colorectal Dis 23:863–868PubMedCrossRef Doeksen A, Tanis PJ, Wüst AFJ et al (2008) Radiological evaluation of colorectal anastomoses. Int J Colorectal Dis 23:863–868PubMedCrossRef
41.
go back to reference Kanellos D, Pramateftakis MG, Vrakas G et al (2010) Anastomotic leakage following anterior resection for rectal cancer. Tech Coloproctol 8(1):S79–S81CrossRef Kanellos D, Pramateftakis MG, Vrakas G et al (2010) Anastomotic leakage following anterior resection for rectal cancer. Tech Coloproctol 8(1):S79–S81CrossRef
42.
go back to reference DuBrow RA, David CL, Curley SA (1995) Anastomotic leaks after low anterior resection for rectal carcinoma: evaluation with CT and barium enema. Am J Roentgenol 165:567–571CrossRef DuBrow RA, David CL, Curley SA (1995) Anastomotic leaks after low anterior resection for rectal carcinoma: evaluation with CT and barium enema. Am J Roentgenol 165:567–571CrossRef
43.
go back to reference Zissin R, Gayer G (2004) Postoperative anatomic and pathologic findings at CT following colonic resection. Semin Ultrasound, CT, and MR 25:222–238CrossRef Zissin R, Gayer G (2004) Postoperative anatomic and pathologic findings at CT following colonic resection. Semin Ultrasound, CT, and MR 25:222–238CrossRef
44.
go back to reference Peel ALG, Taylor EW, Surgical Infection Study Group (1991) Proposed definitions for the audit of postoperative infection: a discussion paper. Ann R Coll Surg Engl 73:385–388PubMed Peel ALG, Taylor EW, Surgical Infection Study Group (1991) Proposed definitions for the audit of postoperative infection: a discussion paper. Ann R Coll Surg Engl 73:385–388PubMed
Metadata
Title
Systematic review on the value of CT scanning in the diagnosis of anastomotic leakage after colorectal surgery
Authors
Verena N. N. Kornmann
Nikki Treskes
Lilian H. F. Hoonhout
Thomas L. Bollen
Bert van Ramshorst
Djamila Boerma
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 4/2013
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-012-1623-3

Other articles of this Issue 4/2013

International Journal of Colorectal Disease 4/2013 Go to the issue