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International Journal of Colorectal Disease

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01-12-2012 | Invited Commentary

Manuscript ‘close shave’ margins do not increase rectal cancer recurrence after sphincter-saving surgery without neoadjuvant therapy by Lim et al.

Authors: Oliver Thomusch, Guenther Ruf

Published in: International Journal of Colorectal Disease | Issue 12/2012

Excerpt

Lim et al. prospectively analysed collected data of 320 patients who underwent curative sphincter-preserving resection for primary rectal cancer between 1999 and 2007. Patients with locally advanced tumours invading or involving surrounding pelvic organs and patients who had received neoadjuvant chemo- or radiotherapy were excluded from analysis. …

Quirke P, Durdey P, Dixon MF, Williams NS (1986) Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 2:996–999PubMedCrossRef

Heald RJ, Moran BJ, Ryall RD et al (1998) Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch Surg 133:894–899PubMedCrossRef

Swedish Rectal Cancer Trial (1997) Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 336:980–987CrossRef

Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731–1740PubMedCrossRef

Kapiteijn E, Marijnen CAM, Nagtegaal ID et al (2001) Preoperative radiotherapy combined with total mesorectal excision for respectable rectal cancer. N Engl J Med 345:638–646PubMedCrossRef

Frykholm GJ, Glimelius B, Pahlman L (1993) Preoperative or postoperative irradiation in adenocarcinoma of the rectum: final treatment results of a randomized trial and an evaluation of late secondary effects. Dis Colon Rectum 36:564–572PubMedCrossRef

Bosset JF, Collette L, Calais G et al (2006) Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 355:1114–1123PubMedCrossRef

Gerard JP, Conroy T, Bonnetain F et al (2006) Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T 3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 24:4620–4625PubMedCrossRef

Sebag-Montefiore D, Stephens RJ, Steele R et al (2009) Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet 373:811–820PubMedCrossRef

10.

Bujko K, Nowacki MP, Nasierowska-Guttmejer A et al (2004) Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol 72:15–24PubMedCrossRef

Title: Manuscript ‘close shave’ margins do not increase rectal cancer recurrence after sphincter-saving surgery without neoadjuvant therapy by Lim et al.
Authors: Oliver Thomusch
Guenther Ruf
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 12/2012
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-012-1529-0

At a glance: The STEP trials

Springer Medicine

Manuscript ‘close shave’ margins do not increase rectal cancer recurrence after sphincter-saving surgery without neoadjuvant therapy by Lim et al.

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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