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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 10/2012

01-10-2012 | Original Article

Metachronous carcinomas in colorectum and its clinicopathological significance

Authors: Alfred King-Yin Lam, Vinod Gopalan, Robert Carmichael, Petra Gertraud Buettner, Melissa Leung, Robert Smith, Cu-Tai Lu, Yik-Hong Ho, Simon Siu

Published in: International Journal of Colorectal Disease | Issue 10/2012

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Abstract

Purpose

The study was designed to examine the significance of colorectal metachronous carcinoma in a large cohort of patients.

Methods

Over a mean follow-up period of 10 years, the clinicopathological features, microsatellite instability (MSI) and clinical follow-up of 56 patients with metachronous colorectal carcinoma were analysed.

Results

The prevalence of metachronous colorectal carcinoma was 2.1 %. The metachronous colorectal carcinomas appeared between 7 and 246 months (mean = 66 months) after surgical resection of the index colorectal carcinomas. Thirty-six per cent (n = 20) of the metachronous carcinoma occurred more than 5 years after the operation of the index carcinoma. Of the 56 patients, 20 % (n = 11) of the metachronous colorectal carcinomas were mucinous adenocarcinoma. Cancers detected in the secondary operations (metachronous colorectal carcinomas), when compared with the primary index cancers, were smaller, showed higher proportions of mucinous adenocarcinoma and more often located in the proximal colon. Patients with metachronous colorectal cancers had higher prevalence of mucinous adenocarcinoma, loss of staining for MSI markers and better survival rates than other patients with colorectal cancers.

Conclusions

Patients with metachronous colorectal carcinomas have characteristic features, and attention to these features is important for better management of this group of cancer.
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Metadata
Title
Metachronous carcinomas in colorectum and its clinicopathological significance
Authors
Alfred King-Yin Lam
Vinod Gopalan
Robert Carmichael
Petra Gertraud Buettner
Melissa Leung
Robert Smith
Cu-Tai Lu
Yik-Hong Ho
Simon Siu
Publication date
01-10-2012
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 10/2012
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-012-1474-y

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