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International Journal of Colorectal Disease

Published in:

01-01-2012 | Original Article

Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis

Authors: Chao Xuan, Bei-Bei Zhang, Tao Yang, Kai-Feng Deng, Ming Li, Rui-Juan Tian

Published in: International Journal of Colorectal Disease | Issue 1/2012

Abstract

Purpose

Although a number of genetic studies have attempted to link organic cation transporter 1/2 (OCTN1/2) polymorphisms to susceptibility of Crohn's disease (CD), the results were often inconsistent. The present study aimed at investigating the associations.

Methods

The PubMed, EBSCO, and BIOSIS databases were searched to identify eligible studies which were published in English before April 2011. The association was assessed by odds ratio (OR) with 95% confidence intervals (CI).

Results

A total of 15 case–control studies, containing 4,489 cases/5,351 controls for OCTN1 and 4,474 cases/5,377 controls for OCTN2 were included. Overall, significant associations were found between OCTN1/2 polymorphisms and susceptibility of Crohn's disease for all genetic models. In the subgroup analyses, significant associations were found in the Caucasian population for OCTN1 (TT vs. CC: OR = 1.425, 95% CI 1.247–1.628; TT vs. CT: OR = 1.299, 95% CI 1.149–1.468; dominant model: OR = 1.344, 95% CI 1.197–1.508; and recessive model: OR = 1.179, 95% CI 1.066–1.305) and for OCTN2 (CC vs. GG: OR = 1.309, 95% CI 1.078–1.588; CC vs. CG: OR = 1.200, 95% CI 1.002–1.438; dominant model (OR = 1.231, 95% CI 1.036–1.462; recessive model: OR = 1.148, 95% CI 1.031–1.279). Significant associations were not found in the East Asian population.

Conclusions

This meta-analysis suggests that OCTN1/2 polymorphisms were associated with susceptibility of CD in the Caucasian population but not in the East Asian population.

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Title: Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis
Authors: Chao Xuan
Bei-Bei Zhang
Tao Yang
Kai-Feng Deng
Ming Li
Rui-Juan Tian
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 1/2012
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-011-1265-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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