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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 12/2011

01-12-2011 | Original Article

Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis

Authors: Ying Zhang, Bang-Shun He, Yu-Qin Pan, Ye-Qiong Xu, Shu-Kui Wang

Published in: International Journal of Colorectal Disease | Issue 12/2011

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Abstract

Introduction

8-Oxoguanine DNA glycosylase 1 (OGG1), a key protein involved in the base excision repair pathway, can recognize and excise several lesions from oligodeoxynucleotides with single DNA damage. A C/G polymorphism at 1,245 bp (C1245G) in exon 7 of the OGG1 (Ser326Cys, rs1052133) is found to have a lower enzymatic activity. A variety of case–control studies have been published evaluating the association between OGG1 Ser326Cys polymorphism and colorectal cancer (CRC), though their conclusions were always contradictory.

Materials and methods

This meta-analysis enrolled 12 studies to estimate the overall risk of OGG1 Ser326Cys polymorphism associated with CRC. The pooled odds ratios (ORs) were performed for codominant model (Cys/Cys versus Ser/Ser; Ser/Cys versus Ser/Ser), dominant model (Ser/Cys + Cys/Cys versus Ser/Ser) and recessive model (Cys/Cys versus Ser/Cys + Ser/Ser).

Results

No significant associations were found for Cys/Cys versus Ser/Ser (OR = 1.19, 95% confidence interval (CI) 0.92–1.53), Ser/Cys versus Ser/Ser (OR = 1.04, 95% CI 0.95–1.13), Ser/Cys + Cys/Cys versus Ser/Ser (OR = 1.06, 95% CI 0.98–1.16) and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.11, 95% CI 0.90–1.38); moreover, in the stratified analyses, no significantly increased risk was found for all genetic models.

Conclusions

Our meta-analysis suggests that the OGG1 Ser326Cys polymorphism is not associated with CRC risk.
Literature
1.
2.
3.
4.
Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Ruschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R, Hamilton SR, Hiatt RA, Jass J, Lindblom A, Lynch HT, Peltomaki P, Ramsey SD, Rodriguez-Bigas MA, Vasen HF, Hawk ET, Barrett JC, Freedman AN, Srivastava S (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96(4):261–268PubMedCrossRef
5.
Dherin C, Radicella JP, Dizdaroglu M, Boiteux S (1999) Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations. Nucleic Acids Res 27(20):4001–4007PubMedCrossRef
6.
Farrington SM, Tenesa A, Barnetson R, Wiltshire A, Prendergast J, Porteous M, Campbell H, Dunlop MG (2005) Germline susceptibility to colorectal cancer due to base-excision repair gene defects. Am J Hum Genet 77(1):112–119PubMedCrossRef
7.
Kim JI, Park YJ, Kim KH, Song BJ, Lee MS, Kim CN, Chang SH (2003) hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer. World J Gastroenterol 9(5):956–960PubMed
8.
Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA (1992) 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and A→C substitutions. J Biol Chem 267(1):166–172PubMed
9.
Fearon ER (1997) Human cancer syndromes: clues to the origin and nature of cancer. Science 278(5340):1043–1050PubMedCrossRef
10.
11.
Audebert M, Radicella JP, Dizdaroglu M (2000) Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein. Nucleic Acids Res 28(14):2672–2678PubMedCrossRef
12.
Gackowski D, Speina E, Zielinska M, Kowalewski J, Rozalski R, Siomek A, Paciorek T, Tudek B, Olinski R (2003) Products of oxidative DNA damage and repair as possible biomarkers of susceptibility to lung cancer. Cancer Res 63(16):4899–4902PubMed
13.
Paz-Elizur T, Ben-Yosef R, Elinger D, Vexler A, Krupsky M, Berrebi A, Shani A, Schechtman E, Freedman L, Livneh Z (2006) Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer. Cancer Res 66(24):11683–11689PubMedCrossRef
14.
Tudek B (2007) Base excision repair modulation as a risk factor for human cancers. Mol Aspects Med 28(3–4):258–275PubMedCrossRef
15.
16.
Hill JW, Evans MK (2006) Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase. Nucleic Acids Res 34(5):1620–1632PubMedCrossRef
17.
Sidorenko VS, Grollman AP, Jaruga P, Dizdaroglu M, Zharkov DO (2009) Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase. FEBS J 276(18):5149–5162PubMedCrossRef
18.
19.
Elahi A, Zheng Z, Park J, Eyring K, McCaffrey T, Lazarus P (2002) The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk. Carcinogenesis 23(7):1229–1234PubMedCrossRef
20.
Takezaki T, Gao CM, Wu JZ, Li ZY, Wang JD, Ding JH, Liu YT, Hu X, Xu TL, Tajima K, Sugimura H (2002) hOGG1 Ser(326)Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese. Int J Cancer 99(4):624–627. doi:10.​1002/​ijc.​10400 PubMedCrossRef
21.
Kohno T, Kunitoh H, Toyama K, Yamamoto S, Kuchiba A, Saito D, Yanagitani N, Ishihara S, Saito R, Yokota J (2006) Association of the OGG1-Ser326Cys polymorphism with lung adenocarcinoma risk. Cancer Sci 97(8):724–728PubMedCrossRef
22.
Le Marchand L, Donlon T, Lum-Jones A, Seifried A, Wilkens LR (2002) Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk. Cancer Epidemiol Biomarkers Prev 11(4):409–412PubMed
23.
Hansen R, Saebo M, Skjelbred CF, Nexo BA, Hagen PC, Bock G, Bowitz Lothe IM, Johnson E, Aase S, Hansteen IL, Vogel U, Kure EH (2005) GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer. Cancer Lett 229(1):85–91PubMedCrossRef
24.
Moreno V, Gemignani F, Landi S, Gioia-Patricola L, Chabrier A, Blanco I, Gonzalez S, Guino E, Capella G, Canzian F (2006) Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. Clin Cancer Res 12(7 Pt 1):2101–2108PubMedCrossRef
25.
Pardini B, Naccarati A, Novotny J, Smerhovsky Z, Vodickova L, Polakova V, Hanova M, Slyskova J, Tulupova E, Kumar R, Bortlik M, Barale R, Hemminki K, Vodicka P (2008) DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic. Mutat Res 638(1–2):146–153PubMed
26.
Sliwinski T, Krupa R, Wisniewska-Jarosinska M, Pawlowska E, Lech J, Chojnacki J, Blasiak J (2009) Common polymorphisms in the XPD and hOGG1 genes are not associated with the risk of colorectal cancer in a Polish population. Tohoku J Exp Med 218(3):185–191PubMedCrossRef
27.
Handoll HH (2006) Systematic reviews on rehabilitation interventions. Arch Phys Med Rehabil 87(6):875PubMedCrossRef
28.
29.
30.
Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4):719–748PubMed
31.
Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634PubMedCrossRef
32.
Yamane A, Kohno T, Ito K, Sunaga N, Aoki K, Yoshimura K, Murakami H, Nojima Y, Yokota J (2004) Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo. Carcinogenesis 25(9):1689–1694. doi:10.​1093/​carcin/​bgh166 PubMedCrossRef
33.
Li H, Hao X, Zhang W, Wei Q, Chen K (2008) The hOGG1 Ser326Cys polymorphism and lung cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 17(7):1739–1745PubMedCrossRef
34.
Metadata
Title
Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis
Authors
Ying Zhang
Bang-Shun He
Yu-Qin Pan
Ye-Qiong Xu
Shu-Kui Wang
Publication date
01-12-2011
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 12/2011
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-011-1258-9

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