Skip to main content
Top
Published in: International Journal of Colorectal Disease 8/2010

01-08-2010 | Original Article

Conversion in laparoscopic-assisted colectomy for right colon cancer: risk factors and clinical outcomes

Authors: Jimmy C. M. Li, Janet F. Y. Lee, Simon S. M. Ng, Raymond Y. C. Yiu, Sophie S. F. Hon, Wing Wa Leung, Ka Lau Leung

Published in: International Journal of Colorectal Disease | Issue 8/2010

Login to get access

Abstract

Purpose

Laparoscopic colon resection is technically challenging, and conversion to open surgery is sometimes unavoidable. The impact of conversion may vary among different types of colorectal resection and pathology. Our present study aims at evaluating the risk factors and clinical outcomes of conversion in laparoscopic resection for right colon cancer.

Methods

Between the periods April 1992 to July 2007, 183 consecutive patients undergoing laparoscopic-assisted right colon resection for carcinoma of colon were identified from our database. Data pertaining demographic information, operative details, postoperative course, complications, length of stay, 30-day mortality, and follow-up status were analyzed.

Results

The overall conversion rate was 12% (22 patients). Stage IV disease, tumor length >5 cm, and surgery performed in an earlier time period (before year 2002) were independent risk factors for conversion. Although the median operative time was comparable (195 vs 180 min, p = 0.074), more blood loss was recorded among the conversion group (350 vs 20 ml, p < 0.001). Conversion was also associated with higher wound infection rate (27.3% vs 5%, p = 0.002) and 30-day mortality (9.1% vs 0.62%, p = 0.039). After potential curative resection, the 5-year overall survival rate of the conversion and no conversion group was 53.8% and 72.6%, respectively (p = 0.039).

Conclusions

Our results showed that conversion increased the intraoperative blood loss, wound related morbidities, and the 30-day mortality. Moreover, it had negative impact on overall survival.
Literature
1.
go back to reference Lacy AM, Garcia-Valdecasas JC, Delgado S, Castells A, Taura P, Pique JM, Visa J (2002) Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet 359:2224–2229CrossRefPubMed Lacy AM, Garcia-Valdecasas JC, Delgado S, Castells A, Taura P, Pique JM, Visa J (2002) Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet 359:2224–2229CrossRefPubMed
2.
go back to reference Leung KL, Kwok SP, Lam SC, Lee JF, Yiu RY, Ng SS, Lai PB, Lau WY (2004) Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Lancet 363:1187–1192CrossRefPubMed Leung KL, Kwok SP, Lam SC, Lee JF, Yiu RY, Ng SS, Lai PB, Lau WY (2004) Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Lancet 363:1187–1192CrossRefPubMed
3.
go back to reference Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, Heath RM, Brown JM, MRC CLASICC trial group (2005) Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial)—multicentre, randomized controlled trial. Lancet 365:1718–1726CrossRefPubMed Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, Heath RM, Brown JM, MRC CLASICC trial group (2005) Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial)—multicentre, randomized controlled trial. Lancet 365:1718–1726CrossRefPubMed
4.
go back to reference Jackson TD, Kaplan GG, Arena G, Page JH, Rogers SO Jr (2007) Laparoscopic versus open resection for colorectal cancer: a meta-analysis of oncologic outcomes. J Am Coll Surg 204:439–446CrossRefPubMed Jackson TD, Kaplan GG, Arena G, Page JH, Rogers SO Jr (2007) Laparoscopic versus open resection for colorectal cancer: a meta-analysis of oncologic outcomes. J Am Coll Surg 204:439–446CrossRefPubMed
5.
go back to reference Fleshman J, Sargent DJ, Green E, Anvari M, Stryker SJ, Beart RW Jr, Hellinger M, Flanagan R Jr, Peters W, Nelson H (2007) Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST study trial group. Ann Surg 246:655–664CrossRefPubMed Fleshman J, Sargent DJ, Green E, Anvari M, Stryker SJ, Beart RW Jr, Hellinger M, Flanagan R Jr, Peters W, Nelson H (2007) Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST study trial group. Ann Surg 246:655–664CrossRefPubMed
6.
go back to reference Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Pahlman L, Cuesta MA, Msika S, Morino M, Lacy AM, Colon Cancer Laparoscopic or Open Resection Study Group (COLOR) (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomized trial. Lancet Oncol 6:477–484CrossRefPubMed Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Pahlman L, Cuesta MA, Msika S, Morino M, Lacy AM, Colon Cancer Laparoscopic or Open Resection Study Group (COLOR) (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomized trial. Lancet Oncol 6:477–484CrossRefPubMed
7.
go back to reference Schwenk W, Haase O, Neudecker J, Muller JM (2005) Short term benefits for laparoscopic colorectal resection. Cochrane Database Syst Rev 20:CD003145 Schwenk W, Haase O, Neudecker J, Muller JM (2005) Short term benefits for laparoscopic colorectal resection. Cochrane Database Syst Rev 20:CD003145
8.
go back to reference Bennett CL, Stryker SJ, Ferreira MR, Adams J, Beart RW Jr (1997) The learning curve for laparoscopic colorectal surgery. Preliminary results from a prospective analysis of 1194 laparoscopic-assisted colectomies. Arch Surg 132:41–44PubMed Bennett CL, Stryker SJ, Ferreira MR, Adams J, Beart RW Jr (1997) The learning curve for laparoscopic colorectal surgery. Preliminary results from a prospective analysis of 1194 laparoscopic-assisted colectomies. Arch Surg 132:41–44PubMed
9.
go back to reference Tekkis PP, Senagore AJ, Delaney CP, Fazio VW (2005) Evaluation of the learning curve in laparoscopic colorectal surgery: comparison of right-sided and left-sided resections. Ann Surg 242:83–91CrossRefPubMed Tekkis PP, Senagore AJ, Delaney CP, Fazio VW (2005) Evaluation of the learning curve in laparoscopic colorectal surgery: comparison of right-sided and left-sided resections. Ann Surg 242:83–91CrossRefPubMed
10.
go back to reference Gervaz P, Pikarsky A, Utech M, Secic M, Efron J, Belin B, Jallin A, Wexner S (2001) Converted laparoscopic colorectal surgery. Surg Endosc 15:827–832CrossRefPubMed Gervaz P, Pikarsky A, Utech M, Secic M, Efron J, Belin B, Jallin A, Wexner S (2001) Converted laparoscopic colorectal surgery. Surg Endosc 15:827–832CrossRefPubMed
11.
go back to reference Slim K, Pezet D, Riff Y, Clark E, Chipponi J (1995) High morbidity rate after converted laparoscopic colorectal surgery. Br J Surg 82:1406–1408CrossRefPubMed Slim K, Pezet D, Riff Y, Clark E, Chipponi J (1995) High morbidity rate after converted laparoscopic colorectal surgery. Br J Surg 82:1406–1408CrossRefPubMed
12.
go back to reference Marusch F, Gastinger I, Schneider C, Scheidbach H, Konradt J, Bruch HP, Köhler L, Bärlehner E, Köckerling F, Laparoscopic Colorectal Surgery Study Group (LCSSG) (2001) Importance of conversion for results obtained with laparoscopic colorectal surgery. Dis Colon Rectum 44:207–214CrossRefPubMed Marusch F, Gastinger I, Schneider C, Scheidbach H, Konradt J, Bruch HP, Köhler L, Bärlehner E, Köckerling F, Laparoscopic Colorectal Surgery Study Group (LCSSG) (2001) Importance of conversion for results obtained with laparoscopic colorectal surgery. Dis Colon Rectum 44:207–214CrossRefPubMed
13.
go back to reference Moloo H, Mamazza J, Poulin EC, Burpee SE, Bendavid Y, Klein L, Gregoire R, Schlachta CM (2004) Laparoscopic resections for colorectal cancer. Surg Endosc 18:732–735CrossRefPubMed Moloo H, Mamazza J, Poulin EC, Burpee SE, Bendavid Y, Klein L, Gregoire R, Schlachta CM (2004) Laparoscopic resections for colorectal cancer. Surg Endosc 18:732–735CrossRefPubMed
14.
go back to reference Schlachta CM, Mamazza J, Seshadri PA, Cadeddu MO, Poulin EC (2000) Predicting conversion to open surgery in laparoscopic colorectal resection. A simple clinical model. Surg Endosc 14:1114–1117CrossRefPubMed Schlachta CM, Mamazza J, Seshadri PA, Cadeddu MO, Poulin EC (2000) Predicting conversion to open surgery in laparoscopic colorectal resection. A simple clinical model. Surg Endosc 14:1114–1117CrossRefPubMed
15.
go back to reference Tekkis PP, Senagore AJ, Delaney CP (2005) Conversion rates in laparoscopic colorectal surgery: a predictive model with 1253 patients. Surg Endosc 19:47–54CrossRefPubMed Tekkis PP, Senagore AJ, Delaney CP (2005) Conversion rates in laparoscopic colorectal surgery: a predictive model with 1253 patients. Surg Endosc 19:47–54CrossRefPubMed
16.
go back to reference Rotholtz NA, Laporte M, Pereyra L, Zanoni G, Bun ME, Aued L, Lencinas S, Mezzadri NA (2008) Predictive factors for conversion in laparoscopic colorectal surgery. Tech Coloproctol 12:27–31CrossRefPubMed Rotholtz NA, Laporte M, Pereyra L, Zanoni G, Bun ME, Aued L, Lencinas S, Mezzadri NA (2008) Predictive factors for conversion in laparoscopic colorectal surgery. Tech Coloproctol 12:27–31CrossRefPubMed
17.
go back to reference Leung KL, Meng WC, Lee JF, Thung KH, Lai PB, Lau WY (1999) Laparoscopic-assisted resection of right-sided colonic carcinoma: a case–control study. J Surg Oncol 71:97–100CrossRefPubMed Leung KL, Meng WC, Lee JF, Thung KH, Lai PB, Lau WY (1999) Laparoscopic-assisted resection of right-sided colonic carcinoma: a case–control study. J Surg Oncol 71:97–100CrossRefPubMed
18.
go back to reference Greene FLP, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, Morrow M (2002) AJCC cancer staging manual, 6th edn. Springer, Philadelphia Greene FLP, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, Morrow M (2002) AJCC cancer staging manual, 6th edn. Springer, Philadelphia
19.
go back to reference Le Moine MC, Fabre JM, Vacher C, Navarro F, Picot MC, Domergue J (2003) Factors and consequences of conversion in laparoscopic sigmoidectomy for diverticular disease. Br J Surg 90:232–236CrossRefPubMed Le Moine MC, Fabre JM, Vacher C, Navarro F, Picot MC, Domergue J (2003) Factors and consequences of conversion in laparoscopic sigmoidectomy for diverticular disease. Br J Surg 90:232–236CrossRefPubMed
20.
go back to reference Schwandner O, Schiedeck TH, Bruch H (1999) The role of conversion in laparoscopic colorectal surgery. Do predictive factors exist? Surg Endosc 13:151–156CrossRefPubMed Schwandner O, Schiedeck TH, Bruch H (1999) The role of conversion in laparoscopic colorectal surgery. Do predictive factors exist? Surg Endosc 13:151–156CrossRefPubMed
21.
go back to reference Gonzalez R, Smith CD, Mason E, Duncan T, Wilson R, Miller J, Ramshaw BJ (2006) Consequences of conversion in laparoscopic colorectal surgery. Dis Colon Rectum 49:197–204CrossRefPubMed Gonzalez R, Smith CD, Mason E, Duncan T, Wilson R, Miller J, Ramshaw BJ (2006) Consequences of conversion in laparoscopic colorectal surgery. Dis Colon Rectum 49:197–204CrossRefPubMed
22.
go back to reference Belizon A, Sardinha CT, Sher ME (2006) Converted laparoscopic colectomy: what are the consequences? Surg Endosc 20:947–951CrossRefPubMed Belizon A, Sardinha CT, Sher ME (2006) Converted laparoscopic colectomy: what are the consequences? Surg Endosc 20:947–951CrossRefPubMed
23.
go back to reference Lord SA, Larach SW, Williamson FA, PR LCP, Lube MW (1996) Laparoscopic resections for colorectal carcinoma. A three-year experience. Dis Colon Rectum 39:148–154CrossRefPubMed Lord SA, Larach SW, Williamson FA, PR LCP, Lube MW (1996) Laparoscopic resections for colorectal carcinoma. A three-year experience. Dis Colon Rectum 39:148–154CrossRefPubMed
24.
go back to reference Schlachta CM, Mamazza J, Seshadri PA, Cadeddu M, Poulin EC (2000) Determinants of outcomes in laparoscopic colorectal surgery: a multiple regression analysis of 416 resections. Surg Endosc 14:258–263CrossRefPubMed Schlachta CM, Mamazza J, Seshadri PA, Cadeddu M, Poulin EC (2000) Determinants of outcomes in laparoscopic colorectal surgery: a multiple regression analysis of 416 resections. Surg Endosc 14:258–263CrossRefPubMed
25.
go back to reference Simons AJ, Anthone GJ, Ortega AE, Franklin M, Fleshman J, Geis WP, Beart RW (1995) Laparoscopic assisted colectomy learning curve. Dis Colon Rectum 38:600–603CrossRefPubMed Simons AJ, Anthone GJ, Ortega AE, Franklin M, Fleshman J, Geis WP, Beart RW (1995) Laparoscopic assisted colectomy learning curve. Dis Colon Rectum 38:600–603CrossRefPubMed
26.
go back to reference Dincler S, Koller MT, Steurer J, Bachmann LM, Christen D, Buchmann P (2003) Multidimensional analysis of learning curves in laparoscopic sigmoid resection: eight-year results. Dis Colon Rectum 46:1371–1378CrossRefPubMed Dincler S, Koller MT, Steurer J, Bachmann LM, Christen D, Buchmann P (2003) Multidimensional analysis of learning curves in laparoscopic sigmoid resection: eight-year results. Dis Colon Rectum 46:1371–1378CrossRefPubMed
27.
go back to reference Li JC, Hon SS, Lee JF, Yiu RY, Leung KL (2009) The learning curve for laparoscopic colectomy: experience of a surgical fellow in an university colorectal unit. Surg Endosc 23:1603–1608 Li JC, Hon SS, Lee JF, Yiu RY, Leung KL (2009) The learning curve for laparoscopic colectomy: experience of a surgical fellow in an university colorectal unit. Surg Endosc 23:1603–1608
Metadata
Title
Conversion in laparoscopic-assisted colectomy for right colon cancer: risk factors and clinical outcomes
Authors
Jimmy C. M. Li
Janet F. Y. Lee
Simon S. M. Ng
Raymond Y. C. Yiu
Sophie S. F. Hon
Wing Wa Leung
Ka Lau Leung
Publication date
01-08-2010
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 8/2010
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-010-0972-z

Other articles of this Issue 8/2010

International Journal of Colorectal Disease 8/2010 Go to the issue