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International Journal of Colorectal Disease

Published in:

01-07-2010 | Original Article

Prognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database

Authors: Gregoire Desolneux, Pascal Burtin, Emilie Lermite, Roberto Bergamaschi, Antoine Hamy, Jean Pierre Arnaud

Published in: International Journal of Colorectal Disease | Issue 7/2010

Abstract

Purpose

There is a need to identify a subgroup of high-risk patients with node-negative colorectal cancer who have a poor long-term prognosis and may benefit from adjuvant therapies. The aim of this study was to evaluate the prognostic impact of clinical and pathological parameters in a retrospective study from a prospective, continuous database of homogenously treated patients.

Methods

This study included 362 patients operated in a single institution for Dukes A and B (node-negative) colorectal cancer. The median follow-up was 140 months. The prognostic value of 13 clinical and pathological parameters was investigated.

Results

Multivariate analysis identified six independent prognostic factors: age at time of diagnosis (hazard ratio (HR) = 1.076), number of lymph nodes removed (HR = 0.948), perineural invasion (HR = 2.173), venous invasion (HR = 1.959), lymphatic vessel invasion (HR = 2.126), and T4 stage (HR = 5.876).

Conclusion

These parameters could be useful in identifying patients with high-risk node-negative colorectal cancer who should be presented to adjuvant therapy.

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Title: Prognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database
Authors: Gregoire Desolneux
Pascal Burtin
Emilie Lermite
Roberto Bergamaschi
Antoine Hamy
Jean Pierre Arnaud
Publication date: 01-07-2010
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 7/2010
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-010-0934-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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