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Published in: International Journal of Colorectal Disease 5/2009

01-05-2009 | Original Article

Surgical treatment of sigmoid diverticulitis—analysis of predictive risk factors for postoperative infections, surgical complications, and mortality

Authors: D. Antolovic, C. Reissfelder, M. Koch, B. Mertens, J. Schmidt, M. W. Büchler, J. Weitz

Published in: International Journal of Colorectal Disease | Issue 5/2009

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Abstract

Background and aims

Sigmoid diverticular disease has great clinical importance due to its increasing incidence in the Western world and a broad spectrum of clinical features with potential fatal complications after surgery. The definition of risk factors associated with postoperative infections, surgical complications and mortality could be helpful in clinical decision-making and optimizing perioperative treatment.

Materials and methods

Based on a prospective database, 168 consecutive patients undergoing surgery for sigmoid diverticulitis were included in this study. The association of different potential risk factors such as age, Hinchey classification, type and duration of operation, surgeons’ experience, blood loss, comorbidities, and hospital course with perioperative complications and mortality were tested by univariate and multivariate analysis.

Results

Of the 168 patients enrolled in this study, there were 84 male and 84 female. A third of patients were operated as emergency cases (within 24 h after surgical evaluation); 62% underwent open surgery, 35% were treated laparoscopically with a conversion rate of 3%. A blood transfusion received 14% of patients, a surgical infection occurred in 20%, surgical complications appeared in 24% with a necessity for re-exploration in 9.5%. Leakage of the primary anastomosis was seen in 3.3%, whereas a leakage of the Hartmann’s stump occurred in 4.3%. Overall in-hospital mortality was 4.1%. Multivariate analysis demonstrated Hinchey classification and intraoperative blood transfusion to be independently associated with postoperative infections, complications and mortality.

Conclusion

Hinchey classification and intraoperative blood transfusion are independently associated with a worse perioperative outcome in patients undergoing surgery for sigmoid diverticular disease. While Hinchey classification cannot be influenced per se by the surgeon, outcome might be influenced by reducing the need for intraoperative blood transfusion.
Literature
1.
go back to reference Jun S, Stollmann N (2002) Epidemiology of diverticular disease. Best Pract Res Clin Gastroenterol 16:529–542PubMedCrossRef Jun S, Stollmann N (2002) Epidemiology of diverticular disease. Best Pract Res Clin Gastroenterol 16:529–542PubMedCrossRef
2.
go back to reference Parks TG (1975) Natural history of diverticular disease of the colon. Clin Gastroenterol 4:53–69PubMed Parks TG (1975) Natural history of diverticular disease of the colon. Clin Gastroenterol 4:53–69PubMed
3.
go back to reference Wong WD et al (2000) Practice parameters for the treatment of sigmoid diverticulitis—supporting documentation. The Standards Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum 43:290–297PubMedCrossRef Wong WD et al (2000) Practice parameters for the treatment of sigmoid diverticulitis—supporting documentation. The Standards Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum 43:290–297PubMedCrossRef
4.
go back to reference Scheidbach H et al (2004) Laparoscopic approach to treatment of sigmoid diverticulitis: changes in the spectrum of indications and results of a prospective, multicenter study on 1,545 patients. Dis Colon Rectum 47:1883–1888PubMedCrossRef Scheidbach H et al (2004) Laparoscopic approach to treatment of sigmoid diverticulitis: changes in the spectrum of indications and results of a prospective, multicenter study on 1,545 patients. Dis Colon Rectum 47:1883–1888PubMedCrossRef
5.
go back to reference Hinchey EJ, Schaal PG, Richards GK (1978) Treatment of perforated diverticular disease of the colon. Adv Surg 12:85–109PubMed Hinchey EJ, Schaal PG, Richards GK (1978) Treatment of perforated diverticular disease of the colon. Adv Surg 12:85–109PubMed
6.
go back to reference Kaiser AM, Jiang JK, Lake JP, Ault G, Artinyan A, Gonzalez-Ruiz C, Essani R, Beart RW Jr (2005) The management of complicated diverticulitis and the role of computed tomography. Am J Gastroenterol 100:910–917PubMedCrossRef Kaiser AM, Jiang JK, Lake JP, Ault G, Artinyan A, Gonzalez-Ruiz C, Essani R, Beart RW Jr (2005) The management of complicated diverticulitis and the role of computed tomography. Am J Gastroenterol 100:910–917PubMedCrossRef
7.
go back to reference Gonzales R et al (2004) Laparoscopic vs open resection for the treatment of diverticular disease. Surg Endosc 18:276–280CrossRef Gonzales R et al (2004) Laparoscopic vs open resection for the treatment of diverticular disease. Surg Endosc 18:276–280CrossRef
9.
go back to reference Schilling MK, Maurer CA, Kollmar O, Buchler MW (2001) Primary vs. secondary anastomosis after sigmoid colon resection for perforated diverticulitis (Hinchey Stage III and IV): a prospective outcome and cost analysis. Dis Colon Rectum 44:699–703PubMedCrossRef Schilling MK, Maurer CA, Kollmar O, Buchler MW (2001) Primary vs. secondary anastomosis after sigmoid colon resection for perforated diverticulitis (Hinchey Stage III and IV): a prospective outcome and cost analysis. Dis Colon Rectum 44:699–703PubMedCrossRef
10.
go back to reference Constantinides VA et al (2006) Primary resection with anastomosis vs. Hartmann's procedure in nonelective surgery for acute colonic diverticulitis: a systematic review. Dis Colon Rectum 49:966–981PubMedCrossRef Constantinides VA et al (2006) Primary resection with anastomosis vs. Hartmann's procedure in nonelective surgery for acute colonic diverticulitis: a systematic review. Dis Colon Rectum 49:966–981PubMedCrossRef
11.
go back to reference Rose J et al (2004) Complications in laparoscopic colorectal surgery: results of a multicentre trial. Tech Coloproctol 8:s25–s28PubMedCrossRef Rose J et al (2004) Complications in laparoscopic colorectal surgery: results of a multicentre trial. Tech Coloproctol 8:s25–s28PubMedCrossRef
12.
go back to reference Kohler L, Sauerland S, Neugebauer E (1999) Diagnosis and treatment of diverticular disease: results of a consensus development conference. The Scientific Committee of European Association for Endoscopic Surgery. Surg Endosc 13:430–436PubMedCrossRef Kohler L, Sauerland S, Neugebauer E (1999) Diagnosis and treatment of diverticular disease: results of a consensus development conference. The Scientific Committee of European Association for Endoscopic Surgery. Surg Endosc 13:430–436PubMedCrossRef
13.
go back to reference Rafferty J, Shellito P, Hyman NH, Buie WD, Standards Committee of American Society of Colon and Rectal Surgeons (2006) Practice parameters for sigmoid diverticulitis. Dis Colon Rectum 49:939–944PubMedCrossRef Rafferty J, Shellito P, Hyman NH, Buie WD, Standards Committee of American Society of Colon and Rectal Surgeons (2006) Practice parameters for sigmoid diverticulitis. Dis Colon Rectum 49:939–944PubMedCrossRef
14.
go back to reference Tang R et al (2001) Risk factors for surgical site infection after elective resection of the colon and rectum: a single-center prospective study of 2,809 consecutive patients. Ann Surg 234:181–189PubMedCrossRef Tang R et al (2001) Risk factors for surgical site infection after elective resection of the colon and rectum: a single-center prospective study of 2,809 consecutive patients. Ann Surg 234:181–189PubMedCrossRef
15.
go back to reference Oomen JL, Engel AF, Cuesta MA (2006) Mortality after acute surgery for complications of diverticular disease of the sigmoid colon is almost exclusively due to patient related factors. Colorectal Dis 8:112–119PubMedCrossRef Oomen JL, Engel AF, Cuesta MA (2006) Mortality after acute surgery for complications of diverticular disease of the sigmoid colon is almost exclusively due to patient related factors. Colorectal Dis 8:112–119PubMedCrossRef
16.
go back to reference Aydin HN, Tekkis PP, Remzi FH, Constantinides V, Fazio VW (2006) Evaluation of the risk of a nonrestorative resection for the treatment of diverticular disease: the Cleveland Clinic diverticular disease propensity score. Dis Colon Rectum 49:629–639PubMedCrossRef Aydin HN, Tekkis PP, Remzi FH, Constantinides V, Fazio VW (2006) Evaluation of the risk of a nonrestorative resection for the treatment of diverticular disease: the Cleveland Clinic diverticular disease propensity score. Dis Colon Rectum 49:629–639PubMedCrossRef
17.
go back to reference Pessaux P et al (2004) Risk factors for mortality and morbidity after elective sigmoid resection for diverticulitis: prospective multicenter multivariate analysis of 582 patients. World J Surg 28:92–96PubMedCrossRef Pessaux P et al (2004) Risk factors for mortality and morbidity after elective sigmoid resection for diverticulitis: prospective multicenter multivariate analysis of 582 patients. World J Surg 28:92–96PubMedCrossRef
18.
go back to reference Simon T et al (2005) Factors associated with complications of open versus laparoscopic sigmoid resection for diverticulitis. JSLS 9:63–67PubMed Simon T et al (2005) Factors associated with complications of open versus laparoscopic sigmoid resection for diverticulitis. JSLS 9:63–67PubMed
19.
go back to reference Lawrence DM, Pasquale MD, Wasser TE (2003) Laparoscopic versus open sigmoid colectomy for diverticulitis. Am Surg 69:499–503PubMed Lawrence DM, Pasquale MD, Wasser TE (2003) Laparoscopic versus open sigmoid colectomy for diverticulitis. Am Surg 69:499–503PubMed
20.
go back to reference Le Moine MC et al (2003) Factors and consequences of conversion in laparoscopic sigmoidectomy for diverticular disease. Br J Surg 90:232–236PubMedCrossRef Le Moine MC et al (2003) Factors and consequences of conversion in laparoscopic sigmoidectomy for diverticular disease. Br J Surg 90:232–236PubMedCrossRef
21.
go back to reference Reissfelder C, Buhr HJ, Ritz JP (2006) What is the optimal time of surgical intervention after an acute attack of sigmoid diverticulitis: early or late elective laparoscopic resection? Dis Colon Rectum 49:1842–1848PubMedCrossRef Reissfelder C, Buhr HJ, Ritz JP (2006) What is the optimal time of surgical intervention after an acute attack of sigmoid diverticulitis: early or late elective laparoscopic resection? Dis Colon Rectum 49:1842–1848PubMedCrossRef
22.
go back to reference Siriser F (1999) Laparoscopic-assisted colectomy for diverticular sigmoiditis. A single-surgeon prospective study of 65 patients. Surg Endosc 13:811–813PubMedCrossRef Siriser F (1999) Laparoscopic-assisted colectomy for diverticular sigmoiditis. A single-surgeon prospective study of 65 patients. Surg Endosc 13:811–813PubMedCrossRef
23.
go back to reference Trebuchet G, Lechaux D, Lecalve JL (2002) Laparoscopic left colon resection for diverticular disease. Surg Endosc 16:18–21PubMedCrossRef Trebuchet G, Lechaux D, Lecalve JL (2002) Laparoscopic left colon resection for diverticular disease. Surg Endosc 16:18–21PubMedCrossRef
24.
go back to reference Vargas HD et al (2000) Defining the role of laparoscopic-assisted sigmoid colectomy for diverticulitis. Dis Colon Rectum 43:1726–1731PubMedCrossRef Vargas HD et al (2000) Defining the role of laparoscopic-assisted sigmoid colectomy for diverticulitis. Dis Colon Rectum 43:1726–1731PubMedCrossRef
25.
go back to reference Reissfelder C, Buhr HJ, Ritz JP (2006) Can laparoscopically assisted sigmoid resection provide uncomplicated management even in cases of complicated diverticulitis? Surg Endosc 20:1055–1059PubMedCrossRef Reissfelder C, Buhr HJ, Ritz JP (2006) Can laparoscopically assisted sigmoid resection provide uncomplicated management even in cases of complicated diverticulitis? Surg Endosc 20:1055–1059PubMedCrossRef
26.
go back to reference Kingston RD, Walsh S, Robinson C, Jeacock J, Keeling F (1995) Significant risk factors in elective colorectal surgery. Ann R Coll Surg Engl 77:369–371PubMed Kingston RD, Walsh S, Robinson C, Jeacock J, Keeling F (1995) Significant risk factors in elective colorectal surgery. Ann R Coll Surg Engl 77:369–371PubMed
27.
go back to reference Sorensen LT et al (1999) Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg 86:927–931PubMedCrossRef Sorensen LT et al (1999) Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg 86:927–931PubMedCrossRef
28.
go back to reference Papagrigoriadis S, Macey L, Bourantas N, Rennie JA (1999) Smoking may be associated with complications in diverticular disease. Br J Surg 86:923–926PubMedCrossRef Papagrigoriadis S, Macey L, Bourantas N, Rennie JA (1999) Smoking may be associated with complications in diverticular disease. Br J Surg 86:923–926PubMedCrossRef
29.
go back to reference Sorensen LT et al (2005) Risk factors for tissue and wound complications in gastrointestinal surgery. Ann Surg 241:654–658PubMedCrossRef Sorensen LT et al (2005) Risk factors for tissue and wound complications in gastrointestinal surgery. Ann Surg 241:654–658PubMedCrossRef
30.
go back to reference Dobbins C, Defontgalland D, Duthie G, Wattchow DA (2006) The relationship of obesity to the complications of diverticular disease. Colorectal Dis 8:37–40PubMedCrossRef Dobbins C, Defontgalland D, Duthie G, Wattchow DA (2006) The relationship of obesity to the complications of diverticular disease. Colorectal Dis 8:37–40PubMedCrossRef
31.
go back to reference Schwandner O, Farke S, Schiedeck TH, Bruch HP (2004) Laparoscopic colorectal surgery in obese and nonobese patients: do differences in body mass indices lead to different outcomes? Surg Endosc 18:1452–1456PubMedCrossRef Schwandner O, Farke S, Schiedeck TH, Bruch HP (2004) Laparoscopic colorectal surgery in obese and nonobese patients: do differences in body mass indices lead to different outcomes? Surg Endosc 18:1452–1456PubMedCrossRef
32.
go back to reference Sitges-Serra A, Insenser JJ, Membrilla E (2006) Blood transfusions and postoperative infections in patients undergoing elective surgery. Surg Infect 7:S33–S35CrossRef Sitges-Serra A, Insenser JJ, Membrilla E (2006) Blood transfusions and postoperative infections in patients undergoing elective surgery. Surg Infect 7:S33–S35CrossRef
33.
go back to reference Torchia MG, Danzinger RG (2000) Perioperative blood transfusion and albumin administration are independent risk factors for the development of postoperative infections after colorectal surgery. Can J Surg 43:212–216PubMed Torchia MG, Danzinger RG (2000) Perioperative blood transfusion and albumin administration are independent risk factors for the development of postoperative infections after colorectal surgery. Can J Surg 43:212–216PubMed
34.
go back to reference Houbiers JG et al (1997) Transfusion of red cells is associated with increased incidence of bacterial infection after colorectal surgery: a prospective study. Transfusion 37:126–134PubMedCrossRef Houbiers JG et al (1997) Transfusion of red cells is associated with increased incidence of bacterial infection after colorectal surgery: a prospective study. Transfusion 37:126–134PubMedCrossRef
35.
go back to reference Carson JL et al (1999) Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair. Transfusion 39:665–670CrossRef Carson JL et al (1999) Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair. Transfusion 39:665–670CrossRef
36.
go back to reference Banbury MK, Brizzio ME, Rajeswaran J, Lytle BW, Blackstone EH (2006) Transfusion increases the risk of postoperative infection after cardiovascular surgery. J Am Coll Surg 202:131–138PubMedCrossRef Banbury MK, Brizzio ME, Rajeswaran J, Lytle BW, Blackstone EH (2006) Transfusion increases the risk of postoperative infection after cardiovascular surgery. J Am Coll Surg 202:131–138PubMedCrossRef
37.
go back to reference Bordin JO, Heddle NM, Blajchman MA (1994) Biologic effects of leukocytes present in transfused cellular blood products. Blood 84:1703–1721PubMed Bordin JO, Heddle NM, Blajchman MA (1994) Biologic effects of leukocytes present in transfused cellular blood products. Blood 84:1703–1721PubMed
Metadata
Title
Surgical treatment of sigmoid diverticulitis—analysis of predictive risk factors for postoperative infections, surgical complications, and mortality
Authors
D. Antolovic
C. Reissfelder
M. Koch
B. Mertens
J. Schmidt
M. W. Büchler
J. Weitz
Publication date
01-05-2009
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 5/2009
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-009-0667-5

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