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International Journal of Colorectal Disease

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01-11-2008 | Original Article

Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study Group

Authors: C. I. Müller, K. Schulmann, A. Reinacher-Schick, N. Andre, D. Arnold, A. Tannapfel, H. Arkenau, S. A. Hahn, S. H.-J. Schmoll, R. Porschen, W. Schmiegel, U. Graeven

Published in: International Journal of Colorectal Disease | Issue 11/2008

Abstract

Background and aims

Microsatellite instability (MSI) is a potential indicator of prognosis in patients with colorectal cancer (CRC). To date, there are a limited number of studies which investigated its role in advanced CRC. Our study investigated the value of high degree of MSI (MSI-H) in patients treated with 5-FU/oxaliplatin-based chemotherapy which has been done by only one further study recently.

Patients and methods

In this study, we investigated tumour tissues from 108 patients with metastatic CRC who were treated in a prospective, randomised trial comparing two oxaliplatin and 5-FU-based therapy regimens (FUFOX vs. CAPOX) involving a total of 474 patients. We determined the incidence and prognostic value of a high degree of microsatellite instability. The specimens were analysed by PCR corresponding to the National Institute of Health reference panel. In addition, immunostaining of the mismatch repair proteins MLH1, MSH2 and MSH6 was performed.

Results and findings

The incidence of MSI-H was 4%. MSI-H was correlated with a lower rate of disease control compared to non-MSI-H patients (p = 0.02). However, there was no correlation between MSI-H and progression-free survival or overall survival.

Interpretation and conclusion

MSI-H incidence in metastatic CRC was low. Our data suggest that MSI-H may be correlated with a poorer response to a 5-FU/oxaliplatin treatment. This finding needs confirmation in a larger cohort.

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Title: Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study Group
Authors: C. I. Müller
K. Schulmann
A. Reinacher-Schick
N. Andre
D. Arnold
A. Tannapfel
H. Arkenau
S. A. Hahn
S. H.-J. Schmoll
R. Porschen
W. Schmiegel
U. Graeven
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 11/2008
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-008-0504-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study Group

Abstract

Background and aims

Patients and methods

Results and findings

Interpretation and conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background and aims

Patients and methods

Results and findings

Interpretation and conclusion

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