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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 9/2007

01-09-2007 | Case Report

Sulfasalazine-induced pericarditis in a patient with ulcerative colitis without recurrence when switching to mesalazine

Authors: Serge Perrot, Elisabeth Aslangul, Tali Szwebel, Houdha Gadhoum, Sophie Romnicianu, Claire Le Jeunne

Published in: International Journal of Colorectal Disease | Issue 9/2007

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Abstract

Introduction

Pericarditis is rarely reported in inflammatory bowel disease. Besides its common causes, pericarditis could be related to ulcerative colitis flare or to 5-aminosalicylic acid (5-ASA) treatment.

Case report

We report the case of a patient in whom fever, weight loss and pericarditis developed after 16 years of treatment with sulfasalazine for ulcerative colitis, after increasing the daily dosage from 1 to 3 g.

Discussion

The patient recovered after treatment discontinuation and did not exhibit any recurrence of pericarditis when treatment with mesalazine was introduced.

Conclusion

In conclusion, if pericarditis occurs in ulcerative colitis patients treated with 5-ASA compounds, the treatment should be considered as a possible cause, even after an increase of the dosage. In this case, discontinuation of the treatment and cautious switch to another 5-ASA compound should be tested.
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Metadata
Title
Sulfasalazine-induced pericarditis in a patient with ulcerative colitis without recurrence when switching to mesalazine
Authors
Serge Perrot
Elisabeth Aslangul
Tali Szwebel
Houdha Gadhoum
Sophie Romnicianu
Claire Le Jeunne
Publication date
01-09-2007
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 9/2007
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-007-0310-2

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