Top

Pediatric Surgery International

Published in:

01-12-2023 | Nephroblastoma | Original Article

Efficacy analysis of multidisciplinary treatment for Wilms tumor in a single center

Authors: Fengming Ji, Chengchuang Wu, Ye Li, Chenghao Zhanghuang, Jinrong Li, Li Li, Zhen Yang, Bing Yan

Published in: Pediatric Surgery International | Issue 1/2023

Abstract

Objective

To analyze the efficacy of multidisciplinary treatment for Wilms tumor (WT) in Kunming Children’s Hospital, and investigate the risk factors affecting the prognosis of WT.

Methods

The clinic-pathological data were collected and analyzed in patients with unilateral WT treated in Kunming Children's Hospital from January 2017 to July 2021. Research subjects were selected according to inclusion criteria and exclusion criteria. The risk factors and independent risk factors that affect the prognosis of patients with WT were determined by Kaplan–Meier survival analysis and Cox proportional hazards model, respectively.

Outcome

A total of 68 children were included in this study, and the 5-year overall survival (OS) rate was 87.4%. Kaplan–Meier survival analysis results showed that ethnicity (P = 0.020), the tumor volume of resection (P = 0.001), histological type (P < 0.001), and postoperative recurrence (P < 0.001) were the risk factors affecting the prognosis of children with WT. The results of the Cox proportional hazards model showed that only the histological type (P = 0.018) was the independent risk factor for the prognosis of WT.

Conclusion

The efficacy of multidisciplinary treatment for WT was satisfying. The histological type has important predictive value for the prognosis of WT, and the patient with unfavorable histology has a poor prognosis.

Stokes CL, Stokes WA, Kalapurakal JA et al (2018) Timing of radiation therapy in pediatric Wilms tumor: a report from the national cancer database. Int J Radiat Oncol Biol Phys 101(2):453–461CrossRefPubMed

Coorens T, Treger TD, Al-Saadi R et al (2019) Embryonal precursors of Wilms tumor. Science 366(6470):1247–1251CrossRefPubMedPubMedCentral

Petiti J, Rosso V, Lo Iacono M et al (2018) Prognostic significance of The Wilms’ Tumor-1 (WT1) rs16754 polymorphism in acute myeloid leukemia. Leuk Res 67:6–11CrossRefPubMed

Rakheja D, Khokhar S, Mitui M, Cost NG (2012) Immunohistochemical expression of GLUT1 and its correlation with unfavorable histology and TP53 codon 72 polymorphism in Wilms tumors. Pediatr Dev Pathol 15(4):286–292CrossRefPubMed

Camp ND, James RG, Dawson DW et al (2012) Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. J Biol Chem 287(9):6539–6550CrossRefPubMedPubMedCentral

Hontecillas-Prieto L, García-Domínguez DJ, García-Mejías R, Ramírez-Villar GL, Sáez C, de Álava E (2017) HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients. Oncotarget 8(70):115290–115303CrossRefPubMedPubMedCentral

Raffensperger J (2015) Max Wilms and his tumor. J Pediatr Surg 50(2):356–359CrossRefPubMed

Nakata K, Colombet M, Stiller CA, Pritchard-Jones K, Steliarova-Foucher E (2020) IICC-3 Contributors. Incidence of childhood renal tumours: An international population-based study. Int J Cancer 147(12):3313–3327

Breslow N, Olshan A, Beckwith JB, Green DM (1993) Epidemiology of Wilms tumor. Med Pediatr Oncol 21(3):172–181CrossRefPubMed

10.

Bahoush G, Saeedi E (2020) Outcome of children with Wilms’ tumor in developing countries. J Med Life 13(4):484–489CrossRefPubMedPubMedCentral

11.

Lopes RI, Lorenzo A (2017) Recent advances in the management of Wilms' tumor. F1000Res 6:670

12.

Nakamura L, Ritchey M (2010) Current management of Wilms’ tumor. Curr Urol Rep 11(1):58–65CrossRefPubMed

13.

Vujanić GM, D’Hooghe E, Graf N et al (2021) Prognostic significance of histopathological response to preoperative chemotherapy in unilateral Wilms’ tumor: an analysis of 899 patients treated on the SIOP WT 2001 protocol in the UK-CCLG and GPOH studies. Int J Cancer 149(6):1332–1340CrossRefPubMed

14.

Chiang KM, Tsay YC, Vincent Ng TC et al (2019) Is hyperuricemia, an early-onset metabolic disorder, causally associated with cardiovascular disease events in Han Chinese. J Clin Med 8(8)

15.

Indorewalla KK, O’Connor MK, Budson AE, Guess DiTerlizzi C, Jackson J (2021) Modifiable barriers for recruitment and retention of older adults participants from underrepresented minorities in Alzheimer’s disease research. J Alzheimers Dis 80(3):927–940CrossRefPubMedPubMedCentral

16.

Bell CN, Thorpe RJ Jr, Bowie JV, LaVeist TA (2018) Race disparities in cardiovascular disease risk factors within socioeconomic status strata. Ann Epidemiol 28(3):147–152CrossRefPubMed

17.

Pillay B, Wootten AC, Crowe H et al (2016) The impact of multidisciplinary team meetings on patient assessment, management and outcomes in oncology settings: a systematic review of the literature. Cancer Treat Rev 42:56–72CrossRefPubMed

18.

Li W, Hua RX, Wang M et al (2021) H19 gene polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study. Mol Genet Genomic Med 9(2):e1584CrossRefPubMedPubMedCentral

19.

Nakata K, Williams R, Kinoshita Y et al (2021) Comparative analysis of the clinical characteristics and outcomes of patients with Wilms tumor in the United Kingdom and Japan. Pediatr Blood Cancer 68(10):e29143CrossRefPubMed

20.

Cox S, Büyükünal C, Millar A (2020) Surgery for the complex Wilms tumour. Pediatr Surg Int 36(2):113–127CrossRefPubMed

21.

Zhang Y, Song HC, Yang YF, Sun N, Zhang WP, Huang CR (2021) Preoperative Wilms tumor rupture in children. Int Urol Nephrol 53(4):619–625CrossRefPubMed

22.

Junjun J, Xuelian Z, Dhruba K, Haiyang X, Lin Z, Shusen Z (2015) Efficacy of preoperative chemotherapy in treatment of children with Wilms’ tumor: a meta-analysis. Iran J Pediatr 25(2):e366CrossRefPubMedPubMedCentral

23.

Groenendijk A, Spreafico F, de Krijger RR et al (2021) Prognostic factors for Wilms Tumor recurrence: a review of the literature. Cancers (Basel) 13(13)

24.

Powis M, Messahel B, Hobson R, Gornall P, Walker J, Pritchard-Jones K (2013) Surgical complications after immediate nephrectomy versus preoperative chemotherapy in non-metastatic Wilms’ tumour: findings from the 1991–2001 United Kingdom Children’s Cancer Study Group UKW3 Trial. J Pediatr Surg 48(11):2181–2186CrossRefPubMed

25.

Graf N, Tournade MF, de Kraker J (2000) The role of preoperative chemotherapy in the management of Wilms' tumor. The SIOP studies. International Society of Pediatric Oncology. Urol Clin North Am 27(3):443–54

26.

Godzinski J, van Tinteren H, de Kraker J et al (2011) Nephroblastoma: does the decrease in tumor volume under preoperative chemotherapy predict the lymph nodes status at surgery. Pediatr Blood Cancer 57(7):1266–1269CrossRefPubMed

27.

Rutigliano DN, Kayton ML, Steinherz P, Wolden S, La Quaglia MP (2007) The use of preoperative chemotherapy in Wilms’ tumor with contained retroperitoneal rupture. J Pediatr Surg 42(9):1595–1599CrossRefPubMed

28.

Jain J, Sutton KS, Hong AL (2021) Progress update in pediatric renal tumors. Curr Oncol Rep 23(3):33CrossRefPubMed

29.

Green DM, Beckwith JB, Breslow NE et al (1994) Treatment of children with stages II to IV anaplastic Wilms’ tumor: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 12(10):2126–2131CrossRefPubMed

30.

Dome JS, Perlman EJ, Graf N (2014) Risk stratification for wilms tumor: current approach and future directions. Am Soc Clin Oncol Educ Book 215–23

31.

Vujanić GM, Gessler M, Ooms A et al (2018) The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat Rev Urol 15(11):693–701CrossRefPubMedPubMedCentral

32.

Dome JS, Cotton CA, Perlman EJ et al (2006) Treatment of anaplastic histology Wilms’ tumor: results from the fifth National Wilms’ Tumor Study. J Clin Oncol 24(15):2352–2358CrossRefPubMed

33.

Vujanić GM, Harms D, Sandstedt B, Weirich A, de Kraker J, Delemarre JF (1999) New definitions of focal and diffuse anaplasia in Wilms tumor: the International Society of Paediatric Oncology (SIOP) experience. Med Pediatr Oncol 32(5):317–323CrossRefPubMed

34.

Spreafico F, Fernandez CV, Brok J et al (2021) Wilms tumour. Nat Rev Dis Primers 7(1):75CrossRefPubMed

35.

Maschietto M, Williams RD, Chagtai T et al (2014) TP53 mutational status is a potential marker for risk stratification in Wilms tumour with diffuse anaplasia. PLoS ONE 9(10):e109924CrossRefPubMedPubMedCentral

Title: Efficacy analysis of multidisciplinary treatment for Wilms tumor in a single center
Authors: Fengming Ji
Chengchuang Wu
Ye Li
Chenghao Zhanghuang
Jinrong Li
Li Li
Zhen Yang
Bing Yan
Publication date: 01-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Nephroblastoma
Cytostatic Therapy
Published in: Pediatric Surgery International / Issue 1/2023
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-023-05408-y

At a glance: The STEP trials

Springer Medicine

Efficacy analysis of multidisciplinary treatment for Wilms tumor in a single center

Abstract

Objective

Methods

Outcome

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Outcome

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2023

Letter to the editor re: Malla et al. Management dilemma in pelvi-ureteric junction obstruction: is cortical transit time the answer?

Development of minimally invasive cancer immunotherapy using anti-disialoganglioside GD2 antibody-producing mesenchymal stem cells for a neuroblastoma mouse model

Reduction of recurrence by peritoneal thermal injury in laparoscopic percutaneous extraperitoneal closure of internal ring for inguinal hernia in children

Isolated aortic arch anomalies are associated with defect severity and outcome in patients with congenital diaphragmatic hernia

Multidisciplinary management of pediatric malignant rhabdoid tumor based on 5 years of experience at a tertiary care center

Saving the perineal body in the vestibular fistula