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01-12-2023 | Esophageal Atresia | Original Article

Preexisting neural factors that contribute to dysmotility in esophageal atresia: a systematic review

Authors: Sharman P. Tan Tanny, Jonez E. A. Roring, Natasha Y. Situmorang, Sebastian K. King, Warwick J. Teague

Published in: Pediatric Surgery International | Issue 1/2023

Abstract

Esophageal dysmotility in esophageal atresia (EA) relates to abnormal development of esophageal innervation and musculature and to the esophageal repair. Few studies have investigated the preexisting dysmotility in EA, present prior to surgery. This systematic review aims to summarize the literature on neuronal studies in EA, to understand the causative factors for esophageal dysmotility. We performed a systematic review (PubMed, EMBASE, EBM, CINAHL databases; January 1947–February 2021) in accordance with PRISMA (PROSPERO number CRD42020171014). Fourteen studies were identified (eleven human, 187 EA patients; three animal, 64 EA rat specimens). Neural factors affecting esophageal dysmotility in human and animal studies included proteins, enzymes, growth factors, and genes, which play a role in the nervous system or neuroendocrine system, some of which have functions as neuromodulators or neurotransmitters. This systematic review has identified neural factors that affect esophageal dysmotility and contributes toward our understanding of the underlying dysmotility in patients with EA. The studies identified are important and essential for successful translation of basic science knowledge to impact clinical practice and understanding. Level of evidence: III.

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Title: Preexisting neural factors that contribute to dysmotility in esophageal atresia: a systematic review
Authors: Sharman P. Tan Tanny
Jonez E. A. Roring
Natasha Y. Situmorang
Sebastian K. King
Warwick J. Teague
Publication date: 01-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Esophageal Atresia
Oesophageal Atresia
Published in: Pediatric Surgery International / Issue 1/2023
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-022-05353-2

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Preexisting neural factors that contribute to dysmotility in esophageal atresia: a systematic review

Abstract

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