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Published in:

01-12-2023 | Original Article

The effect of spring diameter on porcine ileal distraction enterogenesis

Authors: Fereshteh Salimi-Jazi, Anne-Laure Thomas, Talha Rafeeqi, Modupeola Diyaolu, Lauren S. Y. Wood, James C. Y. Dunn

Published in: Pediatric Surgery International | Issue 1/2023

Abstract

Purpose

Spring-mediated distraction enterogenesis has proven to be successful for intestinal lengthening. We aimed to evaluate the effect of spring diameter mismatch on intestinal adaptation.

Methods

Juvenile mini-Yucatan pigs underwent placement of compressed nitinol springs with diameter of 10, 11, or 12 mm into the ileal lumen. Pigs were euthanized on postoperative day 7. The lengths, histology, total area of blood vessels, and enteric ganglia were evaluated.

Results

All spring groups exhibited significant ileal lengthening. Across the different diameters, spring-expanded segments were similar in terms of ileal lengthening, crypt height, muscular thickness, blood vessels, and enteric ganglia area.

Conclusion

Spring-mediated distraction enterogenesis is successful in the porcine ileum. A smaller diameter spring is as effective as a larger diameter spring in lengthening the ileum. Springs of varying diameters result in comparable structural changes in the ileum.

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Title: The effect of spring diameter on porcine ileal distraction enterogenesis
Authors: Fereshteh Salimi-Jazi
Anne-Laure Thomas
Talha Rafeeqi
Modupeola Diyaolu
Lauren S. Y. Wood
James C. Y. Dunn
Publication date: 01-12-2023
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 1/2023
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-022-05300-1

At a glance: The STEP trials

Springer Medicine

The effect of spring diameter on porcine ileal distraction enterogenesis

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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