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01-10-2018 | Original Article

Clinical features and risk factors of bile duct perforation associated with pediatric congenital biliary dilatation

Authors: Hiroaki Fukuzawa, Naoto Urushihara, Chisato Miyakoshi, Keisuke Kajihara, Insu Kawahara, Kaori Isono, Yoshitomo Samejima, Shizu Miura, Kotaro Uemura, Keiichi Morita, Makoto Nakao, Akiko Yokoi, Koji Fukumoto, Masaya Yamoto, Kosaku Maeda

Published in: Pediatric Surgery International | Issue 10/2018

Abstract

Purpose

This study aimed to investigate the clinical features and risk factors of bile duct perforation in pediatric congenital biliary dilatation (CBD) patients.

Methods

CBD patients, whose initial symptom was abdominal pain, were enrolled in this study and were divided into perforated and non-perforated groups. The clinical features of the perforated group were investigated. Moreover, the age at operation, sex, and morphologic features of the extrahepatic bile duct were compared between the groups.

Results

Fifteen cases of bile duct perforation (10.4%) were identified among the 144 CBD patients who had abdominal pain. Majority of bile duct perforation occurred in patients aged < 4 years. The median duration from onset of abdominal pain to bile duct perforation was 6 (4–14) days. Age at onset [< 4 years old; P = 0.02, OR 13.9, (1.663, 115.3)], shape of extrahepatic bile duct [non-cystic type; P = 0.009, OR 8.36, (1.683, 41.5)], and dilatation of the common channel [P = 0.02, OR 13.6, (1.651, 111.5)] were risk factors of bile duct perforation.

Conclusions

Emergent bile duct drainage might be planned to prevent bile duct perforation if CBD patients have the abovementioned risk factors and experience persistent abdominal pain lasting for a few days from onset.

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Title: Clinical features and risk factors of bile duct perforation associated with pediatric congenital biliary dilatation
Authors: Hiroaki Fukuzawa
Naoto Urushihara
Chisato Miyakoshi
Keisuke Kajihara
Insu Kawahara
Kaori Isono
Yoshitomo Samejima
Shizu Miura
Kotaro Uemura
Keiichi Morita
Makoto Nakao
Akiko Yokoi
Koji Fukumoto
Masaya Yamoto
Kosaku Maeda
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 10/2018
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4321-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Clinical features and risk factors of bile duct perforation associated with pediatric congenital biliary dilatation

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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