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01-10-2018 | Original Article

Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia

Authors: Wataru Sumida, Hiroo Uchida, Takahisa Tainaka, Chiyoe Shirota, Akinari Hinoki, Takazumi Kato, Kazuki Yokota, Kazuo Oshima, Ryo Shirotuki, Kosuke Chiba, Yujiro Tanaka

Published in: Pediatric Surgery International | Issue 10/2018

Abstract

Purpose

Biliary atresia (BA) is characterized by progressive inflammation of the biliary system. This inflammation persists and causes liver fibrosis, although jaundice disappears after Kasai portoenterostomy (KP). We aimed to confirm whether the oral administration of eicosapentaenoic acid (EPA) suppresses liver fibrosis in postoperative patients with BA.

Methods

We reviewed patients who underwent laparoscopic KP (lapKP) between January 2014 and September 2017. From December 2016, 30 mg/kg/day of EPA was orally administered to patients who opted to take medicine (EPA group). Patients who did not receive EPA were assigned to the non-EPA group. Mac-2 binding protein sugar chain modified isomer (M2BPGi) and hyaluronic acid (HA) levels were compared between the two groups in patients showing disappearance of jaundice at 6 months after the first lapKP.

Results

Seventeen patients in the non-EPA group and 11 in the EPA group were enrolled. At 6 months after the first lapKP, 10 patients in the non-EPA group and six in the EPA group were without jaundice. M2BPGi and HA levels were significantly lower in the EPA group.

Conclusions

Liver fibrosis was suppressed in patients without jaundice 6 months after lapKP, who were administered EPA. We believe that periductular inflammation was alleviated by EPA supplementation.

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Title: Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia
Authors: Wataru Sumida
Hiroo Uchida
Takahisa Tainaka
Chiyoe Shirota
Akinari Hinoki
Takazumi Kato
Kazuki Yokota
Kazuo Oshima
Ryo Shirotuki
Kosuke Chiba
Yujiro Tanaka
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 10/2018
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4313-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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