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Pediatric Surgery International
Published in: Pediatric Surgery International 1/2018

01-01-2018 | Original Article

The initial prophylactic antibiotic usage and subsequent necrotizing enterocolitis in high-risk premature infants: a systematic review and meta-analysis

Authors: Xue Fan, Li Zhang, Jun Tang, Chao Chen, Juan Chen, Yi Qu, Dezhi Mu

Published in: Pediatric Surgery International | Issue 1/2018

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Abstract

Objective

To investigate the correlation between the initial prophylactic antibiotic use and the subsequent NEC in high-risk premature infants.

Methods

We performed a literature search of PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Web of Science, and nine studies with a total of 5207 infants were selected for inclusion in this study.

Results

The pooled estimate for the seven studies combined indicating that prophylactic antibiotic usage was associated with a non-significant trend toward increased incidence of NEC [odds ratio (OR) 0.75; 95% confidence interval (CI) 0.26–2.17], and prolonged exposure to prophylactic antibiotics, compared with limited prophylactic antibiotic use, was associated with a significant trend toward the risk of increasing incidence of NEC (OR 1.31; 95% CI 1.08–1.59).

Conclusion

Current evidence does not support the use of prophylactic antibiotics to reduce the incidence of NEC for high-risk premature infants.
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Metadata
Title
The initial prophylactic antibiotic usage and subsequent necrotizing enterocolitis in high-risk premature infants: a systematic review and meta-analysis
Authors
Xue Fan
Li Zhang
Jun Tang
Chao Chen
Juan Chen
Yi Qu
Dezhi Mu
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Surgery International / Issue 1/2018
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI
https://doi.org/10.1007/s00383-017-4207-z

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