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Published in:

01-09-2016 | Original Article

Steroid pulse therapy prevents restenosis following balloon dilatation for esophageal stricture

Authors: Kazuki Yokota, Hiroo Uchida, Akihide Tanano, Chiyoe Shirota, Takahisa Tainaka, Akinari Hinoki, Naruhiko Murase, Kazuo Oshima, Ryo Shirotsuki, Kosuke Chiba

Published in: Pediatric Surgery International | Issue 9/2016

Abstract

Purpose

This study aimed to evaluate the effectiveness of intravenous steroid pulse therapy following balloon dilatation for esophageal stenosis and stricture in children.

Methods

The study enrolled six children, including three with congenital esophageal stenosis and three with anastomotic strictures after surgery for esophageal atresia, all of whom were treated by balloon dilatation combined with high-dose intravenous methylprednisolone pulse therapy. Methylprednisolone was injected intravenously at a dose of 20 mg/kg/day for 2 days, starting from the day of dilatation, followed by 10 mg/kg/day for 2 days, for a total of 4 days.

Results

Esophageal stricture recurred in all three patients with congenital esophageal stenosis despite repeated balloon dilatation without methylprednisolone. However, the symptoms of dysphagia improved and did not recur after systemic steroid pulse therapy following balloon dilatation. Symptoms also resolved in all three patients with anastomotic strictures following balloon dilatation with systemic steroid pulse therapy. All six patients remained asymptomatic after 6–21 months follow-up, with no complications.

Conclusion

Intravenous methylprednisolone pulse therapy following balloon dilatation is safe and effective for the treatment of esophageal stenosis and strictures in children.

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Title: Steroid pulse therapy prevents restenosis following balloon dilatation for esophageal stricture
Authors: Kazuki Yokota
Hiroo Uchida
Akihide Tanano
Chiyoe Shirota
Takahisa Tainaka
Akinari Hinoki
Naruhiko Murase
Kazuo Oshima
Ryo Shirotsuki
Kosuke Chiba
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 9/2016
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-016-3939-5

At a glance: The STEP trials

Springer Medicine

Steroid pulse therapy prevents restenosis following balloon dilatation for esophageal stricture

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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