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Published in:

01-05-2015 | Review Article

Autologous intestinal reconstruction surgery as part of comprehensive management of intestinal failure

Author: Mikko P. Pakarinen

Published in: Pediatric Surgery International | Issue 5/2015

Abstract

Pediatric intestinal failure (IF) remains to be associated with significant morbidity and mortality, the most frequent underlying etiologies being short bowel syndrome (SBS), and primary motility disorders. Management aims to assure growth and development, while preventing complications and facilitating weaning off parenteral support (PS) by fully utilizing adaptation potential of the remaining gut. Probability of survival and weaning off PS is improved by coordinated multidisciplinary intestinal rehabilitation combining individualized physiological enteral and parenteral nutrition (PN), meticulous central line care and medical management with carefully planned surgical care. Increasing evidence suggests that autologous intestinal reconstruction (AIR) surgery is effective treatment for selected short bowel patients. Bowel lengthening procedures normalize pathological adaptation-associated short bowel dilatation with potential to support intestinal absorption and liver function by various mechanisms. Although reversed small intestinal segment, designed to prolong accelerated intestinal transit, improves absorption in adult SBS, its feasibility in children remains unclear. Controlled bowel obstruction to induce dilatation followed by bowel lengthening aims to gain extra length in patients with the shortest duodenojejunal remnant. Reduced PS requirement limits the extent of complications, improving prognosis and quality of life. The great majority of children with SBS can be weaned from PS while prognosis of intractable primary motility disorders remains poor without intestinal transplantation, which serves as a salvage therapy for life-threatening complications such as liver failure, central vein thrombosis or recurrent bloodstream infections.

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Title: Autologous intestinal reconstruction surgery as part of comprehensive management of intestinal failure
Author: Mikko P. Pakarinen
Publication date: 01-05-2015
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 5/2015
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-015-3696-x

At a glance: The STEP trials

Springer Medicine

Autologous intestinal reconstruction surgery as part of comprehensive management of intestinal failure

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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