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Pediatric Surgery International

Published in:

01-04-2014 | Original Article

Endoscopic correction of complex cases of vesicoureteral reflux utilizing Vantris as a new non-biodegradable tissue-augmenting substance

Authors: Boris Chertin, Wael Abu Arafeh, Stanislav Kocherov

Published in: Pediatric Surgery International | Issue 4/2014

Abstract

Purpose

We aimed to evaluate prospectively the efficacy of Vantris as a new non-biodegradable tissue-augmenting substance in children with complex cases of VUR.

Materials and methods

Over the last 4 years, 37 children (28 female and 9 male) with a mean age of 5.8 ± 3.1 years (mean ± SD) underwent endoscopic correction of complex VUR. A total of 38 renal refluxing units (RRU) was treated as 5 had persistent reflux after open surgery, 16 had duplication, 4 had Hutch diverticulum, 6 had small poorly functioning kidneys (less than 20 % of relative renal function) with grade V VUR, 2 had ureterocele after puncture, 3 had persistent stump reflux, 1 had prune belly syndrome, and 1 had urogenital sinus. VUR was Grade I in 2, Grade II in 9, Grade III in 11, Grade IV in 10, and Grade V in 6 RRU, respectively.

Results

The reflux was corrected in 34 (89.4 %) RRU after a single injection, after second injection in 2 (5.3 %) RRU. In 2 (5.3 %) RRU, VUR downgraded to Grade I (1RRU) and Grade II (1RRU) and they were taken off antibiotic prophylaxis. VCUG was performed in 11 (73.3 %) of 15 children who completed 1 year and in 3 (33.3 %) of 9 who completed 3 years of follow up as a part of the routine protocol. None showed VUR recurrence. US demonstrated normal appearance of kidneys in all patients.

Conclusion

Our data show that Vantris injection provides a high level of reflux resolution in complex cases of VUR.

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Title: Endoscopic correction of complex cases of vesicoureteral reflux utilizing Vantris as a new non-biodegradable tissue-augmenting substance
Authors: Boris Chertin
Wael Abu Arafeh
Stanislav Kocherov
Publication date: 01-04-2014
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 4/2014
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-014-3468-z

At a glance: The ONWARDS insulin icodec trials

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Endoscopic correction of complex cases of vesicoureteral reflux utilizing Vantris as a new non-biodegradable tissue-augmenting substance

Abstract

Purpose

Materials and methods

Results

Conclusion

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Abstract

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Materials and methods

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