Published in:
18-05-2023 | Arteriovenous Malformation | Original Article
Multi-modality treatment approach for paediatric AVMs with quality-of-life outcome measures
Published in: Child's Nervous System | Issue 9/2023
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Purpose
Despite the potentially devastating and permanently disabling effects of paediatric arteriovenous malformations (pAVMs), there is a paucity of studies reporting long-term quality-of-life (QoL) outcomes in AVM patients. We aim to evaluate the management strategies for paediatric intracranial pAVMs in the UK and long-term QoL outcomes using a validated paediatric quality-of-life outcome measure.
Methods
In this single-centre case-series, we retrospectively reviewed a prospectively maintained database of all paediatric patients (i.e. 0–18 years old) with intracranial AVMs, who were managed at Alder Hey Children’s Hospital from July 2007 to December 2021. We also collected the PedsQL 4.0 score for these patients as a measure of QoL.
Results
Fifty-two AVMs were included in our analysis. Forty (80%) were ruptured, 8 (16%) required emergency intervention, 17 (35%) required elective surgery, 15 (30%) underwent endovascular embolisation, and 15 (30%) patients underwent stereotactic radiosurgery. There was an 88% overall obliteration rate. Two (4%) pAVMs rebled, and there were no mortalities. Overall, the mean time from diagnosis to definitive treatment was 144 days (median 119; range 0–586). QoL outcomes were collected for 26 (51%) patients. Ruptured pAVM presentation was associated with worse QoL (p = 0.0008). Location impacted psychosocial scores significantly (71.4, 56.9, and 46.6 for right supratentorial, left supratentorial, and infratentorial, respectively; p = 0.04).
Conclusion
This study shows a staged multi-modality treatment approach to pAVMs is safe and effective, with superior obliteration rates with surgery alone. QoL scores are impacted by AVM presentation and location regardless of treatment modality.