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01-02-2021 | Obesity | Original Article

Novel predictive scoring system for morbid hypothalamic obesity in patients with pediatric craniopharyngioma

Authors: Mohammed A. Fouda, David Zurakowski, R. Michael Scott, Karen J. Marcus, Peter E. Manley, Nicole J. Ullrich, Laurie E. Cohen, Liliana C. Goumnerova

Published in: Child's Nervous System | Issue 2/2021

Abstract

Purpose

To identify the independent risk factors for developing morbid hypothalamic obesity, to propose a predictive scoring system for morbid hypothalamic obesity, and to propose an algorithm for management in order to minimize the risk of developing morbid hypothalamic obesity in patients with pediatric craniopharyngioma.

Methods

A retrospective analysis of all pediatric craniopharyngioma patients diagnosed and treated at Boston Children’s Hospital (BCH) between 1985 and 2017. Analysis of the data was conducted using IBM SPSS Statistics.

Results

We identified 105 patients, 90 (47 males and 43 females) fulfilled the inclusion criteria. The median age of patients at time of diagnosis was 8.4 years. The median follow-up was 10.6 years. Morbid hypothalamic obesity was evident in 28 (31.1%) patients at the last follow-up visit. Age of patients at time of diagnosis > 10 years (P = 0.023), preoperative body mass index (BMI) > 95th percentile (P = 0.006), and preoperative papilledema (P < 0.001) were the independent risk factors for developing morbid hypothalamic obesity.

Conclusion

We developed a unique predictive scoring system in order to differentiate between patients with and without high risk for developing morbid hypothalamic obesity.

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Title: Novel predictive scoring system for morbid hypothalamic obesity in patients with pediatric craniopharyngioma
Authors: Mohammed A. Fouda
David Zurakowski
R. Michael Scott
Karen J. Marcus
Peter E. Manley
Nicole J. Ullrich
Laurie E. Cohen
Liliana C. Goumnerova
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Obesity
Craniopharyngioma
Obesity
Hydrocephalus
Hydrocephalus
Hydrocephalus
Published in: Child's Nervous System / Issue 2/2021
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-020-04877-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Novel predictive scoring system for morbid hypothalamic obesity in patients with pediatric craniopharyngioma

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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