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Child's Nervous System
Published in: Child's Nervous System 10/2020

Open Access 01-10-2020 | Ultrasound | Annual issue paper

Role of high-resolution ultrasound in detection and monitoring of peripheral nerve tumor burden in neurofibromatosis in children

Authors: Natalie Winter, Maike F. Dohrn, Julia Wittlinger, Alexander Loizides, Hannes Gruber, Alexander Grimm

Published in: Child's Nervous System | Issue 10/2020

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Abstract

Purpose

Peripheral nerve sheath tumors are hallmark findings in neurofibromatosis types 1 and 2. With increasing size, they typically lead to neurological symptoms, and NF1 patients have a lifetime risk of 8–13% for developing malignant peripheral nerve sheath tumors. Medical imaging is therefore highly needed for early detection and exact localization of symptomatic or potentially malignant tumors. This review will give an overview of the ultrasound characteristics of peripheral nerve sheath tumors and findings in patients with neurofibromatosis types 1 and 2.

Methods

A systematic search of electronic databases, reference lists, and unpublished literature was conducted including the keywords “schwannoma,” “neurofibroma,” “neurofibromatosis,” “benign and malignant peripheral nerve sheath tumor.”

Results

The high-resolution allows a clear analysis of tumor echotexture, definition of margins, and the relation to the parent nerve. The use of color duplex/Doppler and contrast agent adds valuable information for the differentiation of benign and malignant tumors.

Conclusion

High-resolution ultrasound is a well-established, non-invasive, and easily repeatable first-line tool in diagnostic procedures of soft tissue tumors.
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Metadata
Title
Role of high-resolution ultrasound in detection and monitoring of peripheral nerve tumor burden in neurofibromatosis in children
Authors
Natalie Winter
Maike F. Dohrn
Julia Wittlinger
Alexander Loizides
Hannes Gruber
Alexander Grimm
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 10/2020
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-020-04718-z

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