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Published in: Child's Nervous System 9/2019

01-09-2019 | Stroke | Case Report

Suprasellar ganglioglioma presenting as a middle cerebral artery infarction

Authors: Laura Pastor, Sara Iglesias, Bienvenido Ros, Bernardo Weil, María Isabel Martínez-León, Miguel Ángel Arráez

Published in: Child's Nervous System | Issue 9/2019

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Abstract

Background

Gangliogliomas are a relatively rare neoplasm with a major incidence in the pediatric population. As the temporal lobes are the most common site, patients usually present with seizures.

Case report

We report the case of a 9-year-old child with an extensive suprasellar ganglioglioma presenting with a cerebral infarction due to direct compression of the medium cerebral artery.

Conclusions

Suprasellar lesions can compress adjacent vascular structures, so an accurate diagnosis is necessary for an early treatment.
Literature
1.
go back to reference Abbas MS, AlBerawi MN, Al Bozom I, Shaikh NF, Salem KY (2016) Unusual complication of pituitary macroadenoma: a case report and review. Am J Case Rep 17:707–711CrossRefPubMedPubMedCentral Abbas MS, AlBerawi MN, Al Bozom I, Shaikh NF, Salem KY (2016) Unusual complication of pituitary macroadenoma: a case report and review. Am J Case Rep 17:707–711CrossRefPubMedPubMedCentral
2.
go back to reference Bhat DI, Mahadevan A, Manish R, Sampath S, Chandramouli BA, Shankar SK (2010) Intraventricular ganglioglioma with bleed: a rare case report. Neurol India 58:477–480CrossRefPubMed Bhat DI, Mahadevan A, Manish R, Sampath S, Chandramouli BA, Shankar SK (2010) Intraventricular ganglioglioma with bleed: a rare case report. Neurol India 58:477–480CrossRefPubMed
3.
go back to reference Dahiya S, Haydon DH, Alvarado D, Gurnett CA, Gutmann DH, Leonard JR (2013) BRAF (V600E) mutation is a negative prognosticator in pediatric ganglioglioma. Acta Neuropathol 125(6):901–910CrossRefPubMed Dahiya S, Haydon DH, Alvarado D, Gurnett CA, Gutmann DH, Leonard JR (2013) BRAF (V600E) mutation is a negative prognosticator in pediatric ganglioglioma. Acta Neuropathol 125(6):901–910CrossRefPubMed
4.
go back to reference Horbinsky C, Kofler J, Yeaney G, Camelo-Piragua S, Venneti S, Louis DN, Perry A, Murdoch G, Nikiforova M (2011) Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas. Brain Pathol 21:564 Horbinsky C, Kofler J, Yeaney G, Camelo-Piragua S, Venneti S, Louis DN, Perry A, Murdoch G, Nikiforova M (2011) Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas. Brain Pathol 21:564
5.
go back to reference Karaaslan B, Uçar M, Kulduk G, Börcek AÖ, Baykaner MK (2016) Bilateral optic pathway ganglioglioma: the fifth case in the literature. Pediatr Neurosurg 51:48–54CrossRefPubMed Karaaslan B, Uçar M, Kulduk G, Börcek AÖ, Baykaner MK (2016) Bilateral optic pathway ganglioglioma: the fifth case in the literature. Pediatr Neurosurg 51:48–54CrossRefPubMed
6.
go back to reference Koelsche C, Wöhrer A, Jeibmann A, Schittenhelm J, Schindler G, Preusser M, Lasitschka F, von Deimling A, Capper D (2013) Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells. Acta Neuropathol 125:891–900CrossRefPubMed Koelsche C, Wöhrer A, Jeibmann A, Schittenhelm J, Schindler G, Preusser M, Lasitschka F, von Deimling A, Capper D (2013) Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells. Acta Neuropathol 125:891–900CrossRefPubMed
7.
go back to reference Luyken C, Blümcke I, Fimmers R, Urback H, Wiestler OD, Schramm J (2004) Supratentorial gangliogliomas: histophatologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years. Cancer 101(1):146–155CrossRefPubMed Luyken C, Blümcke I, Fimmers R, Urback H, Wiestler OD, Schramm J (2004) Supratentorial gangliogliomas: histophatologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years. Cancer 101(1):146–155CrossRefPubMed
8.
go back to reference Puget S, Alshehri A, Beccaria K, Blauwblomme T, Paternoster G, James S, Dirocco F, Dufour C, Zerah M, Varlet P, Sainte-Rose C (2015) Pediatric infratentorial ganglioglioma. Childs Nerv Syst 31(10):1707–1716CrossRefPubMed Puget S, Alshehri A, Beccaria K, Blauwblomme T, Paternoster G, James S, Dirocco F, Dufour C, Zerah M, Varlet P, Sainte-Rose C (2015) Pediatric infratentorial ganglioglioma. Childs Nerv Syst 31(10):1707–1716CrossRefPubMed
9.
go back to reference Resta IT, Singh A, Gilbert BC, Rojiani MV, Alleyne C, Roijani AM (2018) Suprasellar ganglioglioma: expanding the differential diagnosis. Case Rep Pathol 2018:9486064PubMedPubMedCentral Resta IT, Singh A, Gilbert BC, Rojiani MV, Alleyne C, Roijani AM (2018) Suprasellar ganglioglioma: expanding the differential diagnosis. Case Rep Pathol 2018:9486064PubMedPubMedCentral
10.
go back to reference Rumana CS, Valadka AB (1998) Radiation therapy and malignant degeneration of benign supratentorial gangliogliomas. Neurosrugery 42(5):1038–1043CrossRef Rumana CS, Valadka AB (1998) Radiation therapy and malignant degeneration of benign supratentorial gangliogliomas. Neurosrugery 42(5):1038–1043CrossRef
11.
go back to reference Schroeder JW, Vezina LG (2011) Pediatric sellar and suprasellar lesions. Pediatr Radiol 41(3):287–298CrossRefPubMed Schroeder JW, Vezina LG (2011) Pediatric sellar and suprasellar lesions. Pediatr Radiol 41(3):287–298CrossRefPubMed
12.
go back to reference Seeburg DP, Dremmen MH, Huisman TA (2017) Imaging of the sella and parasellar region in the pediatric population. Neuroimaging Clin N Am 27(1):99–121CrossRefPubMed Seeburg DP, Dremmen MH, Huisman TA (2017) Imaging of the sella and parasellar region in the pediatric population. Neuroimaging Clin N Am 27(1):99–121CrossRefPubMed
13.
go back to reference Shih KC, Shastry M, Williams JT, Jelsma PF, Abram SR, Ayyanar K, Burris HA 3rd, Infante JR (2014) Successful treatment with dabrafenib (GSK2118436) in a patient with ganglioglioma. J Clin Oncol 32(29):e98–e100CrossRefPubMed Shih KC, Shastry M, Williams JT, Jelsma PF, Abram SR, Ayyanar K, Burris HA 3rd, Infante JR (2014) Successful treatment with dabrafenib (GSK2118436) in a patient with ganglioglioma. J Clin Oncol 32(29):e98–e100CrossRefPubMed
14.
go back to reference Shono T, Tosaka M, Matsumoto K, Onaka S, Yamaguchi S, Mizoguchi M, Iwaki T, Nakazato Y, Sasaki T (2007) Ganglioglioma in the third ventricle: report on two cases. Neurosurg Rev 30:253–258 discussion 258CrossRefPubMed Shono T, Tosaka M, Matsumoto K, Onaka S, Yamaguchi S, Mizoguchi M, Iwaki T, Nakazato Y, Sasaki T (2007) Ganglioglioma in the third ventricle: report on two cases. Neurosurg Rev 30:253–258 discussion 258CrossRefPubMed
15.
go back to reference Shuangshoti S, Kirsch E, Bannan P, Fabian VA (2000) Ganglioglioma of the optic chiasm: case report and review of the literature. AJNR Am J Neuroradiol 21(8):1486–1489PubMed Shuangshoti S, Kirsch E, Bannan P, Fabian VA (2000) Ganglioglioma of the optic chiasm: case report and review of the literature. AJNR Am J Neuroradiol 21(8):1486–1489PubMed
16.
go back to reference Warnica W, Provias JP (2017) Intraventricular ganglioglioma with extensive hemorrhage. Clin Neuropathol 36(4):178–182CrossRefPubMed Warnica W, Provias JP (2017) Intraventricular ganglioglioma with extensive hemorrhage. Clin Neuropathol 36(4):178–182CrossRefPubMed
17.
go back to reference Zaky W, Patil SS, Park M, Liu D, Wang WL, Wani KM, Calle S, Ketonen L, Khatua S (2018) Ganglioglioma in children and young adults: single institution experience and review of the literature. J Neuro-Oncol 139:739–747CrossRef Zaky W, Patil SS, Park M, Liu D, Wang WL, Wani KM, Calle S, Ketonen L, Khatua S (2018) Ganglioglioma in children and young adults: single institution experience and review of the literature. J Neuro-Oncol 139:739–747CrossRef
Metadata
Title
Suprasellar ganglioglioma presenting as a middle cerebral artery infarction
Authors
Laura Pastor
Sara Iglesias
Bienvenido Ros
Bernardo Weil
María Isabel Martínez-León
Miguel Ángel Arráez
Publication date
01-09-2019
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 9/2019
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-019-04292-z

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