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Published in: Child's Nervous System 1/2019

01-01-2019 | Review Paper

Peripheral nerve injuries in the pediatric population: a review of the literature. Part III: peripheral nerve tumors in children

Authors: Javier Robla Costales, Mariano Socolovsky, Jaime A. Sánchez Lázaro, Rubén Álvarez García, David Robla Costales

Published in: Child's Nervous System | Issue 1/2019

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Abstract

Introduction

Peripheral nerve tumors type, inciedence and treatment in the pediatric population should be analyzed.

Methods

We have performed an extense literature review of this subject.

Results

incidence and distribution are similar to those observed in adults. The most common peripheral nerve tumors in children are neurofibromas and schwannomas. Malignant peripheral nerve sheath tumors are also observed, specially associated with genetic syndromes, like neurofibromatosis and Carney complex.

Conclusion

In this review, peripheral nerve tumors have been divided into three categories to aid with understanding: reactive and hyperplastic lesions, benign tumors, and malignant tumors. The most frequent lesions have been described.
Literature
1.
go back to reference Baccon J, Wellons JC, Rizk EB (2015) Pediatric peripheral nerve tumors. In: Tubbs RS, Rizk E, Shoja M, Loukas M, Barbaro N, Spinner E (eds) Nerves and nerve injuries. Vol 2: Pain, treatment, injury, disease and future directions. Academic press, London, pp 839–846 Baccon J, Wellons JC, Rizk EB (2015) Pediatric peripheral nerve tumors. In: Tubbs RS, Rizk E, Shoja M, Loukas M, Barbaro N, Spinner E (eds) Nerves and nerve injuries. Vol 2: Pain, treatment, injury, disease and future directions. Academic press, London, pp 839–846
2.
go back to reference Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG (2005) A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg 102:246–255CrossRefPubMed Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG (2005) A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg 102:246–255CrossRefPubMed
3.
go back to reference Rodriguez FJ, Folpe AL, Giannini C, Perry A (2012) Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol (Berl) 123:295–319CrossRef Rodriguez FJ, Folpe AL, Giannini C, Perry A (2012) Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol (Berl) 123:295–319CrossRef
4.
go back to reference Guedes-Corrêa JF, Torrao FJL, Barbosa D (2017) Benign peripheral nerve tumors. In: manual of peripheral nerve surgery: from the basics to complex procedures. Thieme Medical Publishers, Stuttgart, pp 184–194 Guedes-Corrêa JF, Torrao FJL, Barbosa D (2017) Benign peripheral nerve tumors. In: manual of peripheral nerve surgery: from the basics to complex procedures. Thieme Medical Publishers, Stuttgart, pp 184–194
5.
go back to reference Hassell DS, Bancroft LW, Kransdorf MJ, Peterson JJ, Berquist TH, Murphey MD, Fanburg-Smith JC (2008) Imaging appearance of diffuse neurofibroma. AJR Am J Roentgenol 190:582–588CrossRef Hassell DS, Bancroft LW, Kransdorf MJ, Peterson JJ, Berquist TH, Murphey MD, Fanburg-Smith JC (2008) Imaging appearance of diffuse neurofibroma. AJR Am J Roentgenol 190:582–588CrossRef
6.
go back to reference Gabhane SK, Kotwal MN, Bobhate SK (2009) Morphological spectrum of peripheral nerve sheath tumors: a series of 126 cases. Indian J Pathol Microbiol 52:29–33CrossRefPubMed Gabhane SK, Kotwal MN, Bobhate SK (2009) Morphological spectrum of peripheral nerve sheath tumors: a series of 126 cases. Indian J Pathol Microbiol 52:29–33CrossRefPubMed
7.
go back to reference Evans DGR (2009) Neurofibromatosis 2 [bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]. Genet Med Off J Am Coll Med Genet 11:599–610 Evans DGR (2009) Neurofibromatosis 2 [bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]. Genet Med Off J Am Coll Med Genet 11:599–610
8.
go back to reference MacCollin M, Chiocca EA, Evans DG, Friedman JM, Horvitz R, Jaramillo D, Lev M, Mautner VF, Niimura M, Plotkin SR, Sang CN, Stemmer-Rachamimov A, Roach ES (2005) Diagnostic criteria for schwannomatosis. Neurology 64:1838–1845CrossRef MacCollin M, Chiocca EA, Evans DG, Friedman JM, Horvitz R, Jaramillo D, Lev M, Mautner VF, Niimura M, Plotkin SR, Sang CN, Stemmer-Rachamimov A, Roach ES (2005) Diagnostic criteria for schwannomatosis. Neurology 64:1838–1845CrossRef
9.
go back to reference Rodriguez FJ, Stratakis CA, Evans DG (2012) Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes. Acta Neuropathol (Berl) 123:349–367CrossRef Rodriguez FJ, Stratakis CA, Evans DG (2012) Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes. Acta Neuropathol (Berl) 123:349–367CrossRef
10.
go back to reference Rankine AJ, Filion PR, Platten MA, Spagnolo DV (2004) Perineurioma: a clinicopathological study of eight cases. Pathology (Phila) 36:309–315 Rankine AJ, Filion PR, Platten MA, Spagnolo DV (2004) Perineurioma: a clinicopathological study of eight cases. Pathology (Phila) 36:309–315
11.
go back to reference Ferraresi S, Garozzo D, Bianchini E, Gasparotti R (2010) Perineurioma of the sciatic nerve: a possible cause of idiopathic foot drop in children: report of 4 cases. J Neurosurg Pediatr 6:506–510CrossRefPubMed Ferraresi S, Garozzo D, Bianchini E, Gasparotti R (2010) Perineurioma of the sciatic nerve: a possible cause of idiopathic foot drop in children: report of 4 cases. J Neurosurg Pediatr 6:506–510CrossRefPubMed
12.
go back to reference Roux A, Tréguier C, Bruneau B, Marin F, Riffaud L, Violas P, Michel A, Gandon Y, Gauvrit JY (2012) Localized hypertrophic neuropathy of the sciatic nerve in children: MRI findings. Pediatr Radiol 42:952–958CrossRefPubMed Roux A, Tréguier C, Bruneau B, Marin F, Riffaud L, Violas P, Michel A, Gandon Y, Gauvrit JY (2012) Localized hypertrophic neuropathy of the sciatic nerve in children: MRI findings. Pediatr Radiol 42:952–958CrossRefPubMed
13.
go back to reference Ridel P, Perrot P, Moreau A, Duteille F (2014) A rare tumor of the median nerve in a young child: intraneural perineurioma. About one clinical case. Ann Chir Plast Esthet 59:204–207CrossRefPubMed Ridel P, Perrot P, Moreau A, Duteille F (2014) A rare tumor of the median nerve in a young child: intraneural perineurioma. About one clinical case. Ann Chir Plast Esthet 59:204–207CrossRefPubMed
14.
go back to reference Al-Adnani M (2017) Soft tissue perineurioma in a child with neurofibromatosis type 1: a case report and review of the literature. Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc 20:444–448CrossRef Al-Adnani M (2017) Soft tissue perineurioma in a child with neurofibromatosis type 1: a case report and review of the literature. Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc 20:444–448CrossRef
15.
go back to reference Spinner RJ, Hébert-Blouin M, Zager EL (2011) Peripheral nerve tumors. In: Siqueira M, Socolovsky M, Malessy M, Devy I (eds) treatment of peripheral nerve lesions. Prism Publications, Bangalore, pp 155–170 Spinner RJ, Hébert-Blouin M, Zager EL (2011) Peripheral nerve tumors. In: Siqueira M, Socolovsky M, Malessy M, Devy I (eds) treatment of peripheral nerve lesions. Prism Publications, Bangalore, pp 155–170
16.
go back to reference Fetsch JF, Laskin WB, Hallman JR, Lupton GP, Miettinen M (2007) Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol 31:1103–1114CrossRefPubMed Fetsch JF, Laskin WB, Hallman JR, Lupton GP, Miettinen M (2007) Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol 31:1103–1114CrossRefPubMed
17.
go back to reference Rasulic L, Samardzic M, Bascarevic V, Micovic M, Cvrkota I, Zivkovic B (2015) A rare case of peripheral nerve hemangioblastoma—case report and literature review. Neurosurg Rev 38:205–209 discussion 209CrossRefPubMed Rasulic L, Samardzic M, Bascarevic V, Micovic M, Cvrkota I, Zivkovic B (2015) A rare case of peripheral nerve hemangioblastoma—case report and literature review. Neurosurg Rev 38:205–209 discussion 209CrossRefPubMed
18.
go back to reference Hornick JL, Fletcher CDM (2007) Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol 31:329–340CrossRefPubMed Hornick JL, Fletcher CDM (2007) Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol 31:329–340CrossRefPubMed
19.
go back to reference Ahmed I, Rawat JD, Singh S et al (2010) Neurothekeoma: a rare sacrococcygeal tumor in a child. J Pediatr Surg 45:1037–1039CrossRefPubMed Ahmed I, Rawat JD, Singh S et al (2010) Neurothekeoma: a rare sacrococcygeal tumor in a child. J Pediatr Surg 45:1037–1039CrossRefPubMed
20.
go back to reference Seo BF, Kang H, Lee JY et al (2013) Ankle neurothekeoma: a case report. J Foot Ankle Surg Off Publ Am Coll Foot Ankle Surg 52:678–680 Seo BF, Kang H, Lee JY et al (2013) Ankle neurothekeoma: a case report. J Foot Ankle Surg Off Publ Am Coll Foot Ankle Surg 52:678–680
21.
go back to reference Skovronsky DM (2004) Pathologic classification of peripheral nerve tumors. Neurosurg Clin N Am 15(2):157–166CrossRefPubMed Skovronsky DM (2004) Pathologic classification of peripheral nerve tumors. Neurosurg Clin N Am 15(2):157–166CrossRefPubMed
22.
go back to reference Modha A (2005) Presacral ganglioneuromas. Report of five cases and review of the literature. J Neurosurg Spine 2(3):366–371CrossRefPubMed Modha A (2005) Presacral ganglioneuromas. Report of five cases and review of the literature. J Neurosurg Spine 2(3):366–371CrossRefPubMed
23.
go back to reference Albuquerque BS (2013) Surgical management of parapharyngeal ganglioneuroma: case report and review of the literature. ORL J Otorhinolaryngol Relat Spec 75(4):240–244CrossRefPubMed Albuquerque BS (2013) Surgical management of parapharyngeal ganglioneuroma: case report and review of the literature. ORL J Otorhinolaryngol Relat Spec 75(4):240–244CrossRefPubMed
25.
go back to reference Scheithauer BW (2008) Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: report of a pediatric example and literature review. Hum Pathol 39(11):1708–1712CrossRefPubMed Scheithauer BW (2008) Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: report of a pediatric example and literature review. Hum Pathol 39(11):1708–1712CrossRefPubMed
26.
go back to reference Bates JE, Peterson CR, Dhakal S, Giampoli EJ, Constine LS (2014) Malignant peripheral nerve sheath tumors (MPNST): a SEER analysis of incidence across the age spectrum and therapeutic interventions in the pediatric population. Pediatr Blood Cancer 61:1955–1960CrossRefPubMed Bates JE, Peterson CR, Dhakal S, Giampoli EJ, Constine LS (2014) Malignant peripheral nerve sheath tumors (MPNST): a SEER analysis of incidence across the age spectrum and therapeutic interventions in the pediatric population. Pediatr Blood Cancer 61:1955–1960CrossRefPubMed
27.
go back to reference Stark AM, Buhl R, Hugo HH, Mehdorn HM (2001) Malignant peripheral nerve sheath tumours--report of 8 cases and review of the literature. Acta Neurochir 143(4):357–363 discussion 363–4CrossRefPubMed Stark AM, Buhl R, Hugo HH, Mehdorn HM (2001) Malignant peripheral nerve sheath tumours--report of 8 cases and review of the literature. Acta Neurochir 143(4):357–363 discussion 363–4CrossRefPubMed
28.
go back to reference Carli M, Ferrari A, Mattke A, Zanetti I, Casanova M, Bisogno G, Cecchetto G, Alaggio R, de Sio L, Koscielniak E, Sotti G, Treuner J (2005) Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group. J Clin Oncol Off J Am Soc Clin Oncol 23:8422–8430CrossRef Carli M, Ferrari A, Mattke A, Zanetti I, Casanova M, Bisogno G, Cecchetto G, Alaggio R, de Sio L, Koscielniak E, Sotti G, Treuner J (2005) Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group. J Clin Oncol Off J Am Soc Clin Oncol 23:8422–8430CrossRef
29.
go back to reference Yohay K (2009) Neurofibromatosis type 1 and associated malignancies. Curr Neurol Neurosci Rep 9:247–253CrossRefPubMed Yohay K (2009) Neurofibromatosis type 1 and associated malignancies. Curr Neurol Neurosci Rep 9:247–253CrossRefPubMed
30.
go back to reference Ferrari A, Bisogno G, Carli M (2007) Management of childhood malignant peripheral nerve sheath tumor. Paediatr Drugs 9:239–248CrossRefPubMed Ferrari A, Bisogno G, Carli M (2007) Management of childhood malignant peripheral nerve sheath tumor. Paediatr Drugs 9:239–248CrossRefPubMed
31.
go back to reference Karpinsky G, Krawczyk MA, Izycka-Swieszewska E, Fatyga A, Budka A, Balwierz W, Sobol G, Zalewska-Szewczyk B, Rychlowska-Pruszynska M, Klepacka T, Dembowska-Baginska B, Kazanowska B, Gabrych A, Bien E (2018) Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor. J Cancer Res Clin Oncol 144:519–529CrossRefPubMedPubMedCentral Karpinsky G, Krawczyk MA, Izycka-Swieszewska E, Fatyga A, Budka A, Balwierz W, Sobol G, Zalewska-Szewczyk B, Rychlowska-Pruszynska M, Klepacka T, Dembowska-Baginska B, Kazanowska B, Gabrych A, Bien E (2018) Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor. J Cancer Res Clin Oncol 144:519–529CrossRefPubMedPubMedCentral
32.
go back to reference Amirian ES, Goodman JC, New P, Scheurer ME (2014) Pediatric and adult malignant peripheral nerve sheath tumors: an analysis of data from the surveillance, epidemiology, and end results program. J Neuro-Oncol 116:609–616CrossRef Amirian ES, Goodman JC, New P, Scheurer ME (2014) Pediatric and adult malignant peripheral nerve sheath tumors: an analysis of data from the surveillance, epidemiology, and end results program. J Neuro-Oncol 116:609–616CrossRef
33.
go back to reference Casanova M, Ferrari A, Spreafico F, Luksch R, Terenziani M, Cefalo G, Massimino M, Gandola L, Lombardi F, Fossati-Bellani F (1999) Malignant peripheral nerve sheath tumors in children: a single-institution twenty-year experience. J Pediatr Hematol Oncol 21:509–513CrossRefPubMed Casanova M, Ferrari A, Spreafico F, Luksch R, Terenziani M, Cefalo G, Massimino M, Gandola L, Lombardi F, Fossati-Bellani F (1999) Malignant peripheral nerve sheath tumors in children: a single-institution twenty-year experience. J Pediatr Hematol Oncol 21:509–513CrossRefPubMed
34.
go back to reference Wesche WA, Khare V, Rao BN et al (1999) Malignant peripheral nerve sheath tumor of bone in children and adolescents. Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc 2:159–167CrossRef Wesche WA, Khare V, Rao BN et al (1999) Malignant peripheral nerve sheath tumor of bone in children and adolescents. Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc 2:159–167CrossRef
35.
36.
go back to reference Omori Y, Tanito K, Ito K, Itoh M, Saeki H, Nakagawa H (2014) A pediatric case of multiple palisaded encapsulated neuromas of the palms and soles. Pediatr Dermatol 31:e107–e109CrossRefPubMed Omori Y, Tanito K, Ito K, Itoh M, Saeki H, Nakagawa H (2014) A pediatric case of multiple palisaded encapsulated neuromas of the palms and soles. Pediatr Dermatol 31:e107–e109CrossRefPubMed
37.
go back to reference Moore RL, White CR (2010) Multiple palisaded encapsulated neuromas in a child without other associated abnormalities. J Am Acad Dermatol 62:358–359CrossRefPubMed Moore RL, White CR (2010) Multiple palisaded encapsulated neuromas in a child without other associated abnormalities. J Am Acad Dermatol 62:358–359CrossRefPubMed
38.
go back to reference Hall LD, Ferringer T (2013) Palisaded encapsulated neuroma. Cutis 92(167):177–178 Hall LD, Ferringer T (2013) Palisaded encapsulated neuroma. Cutis 92(167):177–178
39.
go back to reference Altmeyer P (1979) Histology of a plexiform neuroma with Vater-Pacini-lamellar-corpuscle-like structures. Hautarzt Z Dermatol Venerol Verwandte Geb 30:248–252 Altmeyer P (1979) Histology of a plexiform neuroma with Vater-Pacini-lamellar-corpuscle-like structures. Hautarzt Z Dermatol Venerol Verwandte Geb 30:248–252
40.
go back to reference Spinner RJ, Scheithauer BW, Amrami KK (2009) The unifying articular (synovial) origin of intraneural ganglia: evolution-revelation-revolution. Neurosurgery 65(4 Suppl):A115–A124CrossRefPubMed Spinner RJ, Scheithauer BW, Amrami KK (2009) The unifying articular (synovial) origin of intraneural ganglia: evolution-revelation-revolution. Neurosurgery 65(4 Suppl):A115–A124CrossRefPubMed
41.
go back to reference Robla-Costales J, Socolovsky M, Dubrovsky A et al (2011) Intraneural cysts of the peroneal nerve in childhood: report of 2 cases and literature review. Neurocir Astur Spain 22:324–331CrossRef Robla-Costales J, Socolovsky M, Dubrovsky A et al (2011) Intraneural cysts of the peroneal nerve in childhood: report of 2 cases and literature review. Neurocir Astur Spain 22:324–331CrossRef
42.
go back to reference Consales A, Pacetti M, Imperato A, Valle M, Cama A (2016) Intraneural ganglia of the common peroneal nerve in children: case report and review of the literature. World Neurosurg 86:510.e11–510.e17CrossRef Consales A, Pacetti M, Imperato A, Valle M, Cama A (2016) Intraneural ganglia of the common peroneal nerve in children: case report and review of the literature. World Neurosurg 86:510.e11–510.e17CrossRef
43.
go back to reference Nucci F, Artico M, Santoro A, Bardella L, Delfini R, Bosco S, Palma L (1990) Intraneural synovial cyst of the peroneal nerve: report of two cases and review of the literature. Neurosurgery 26:339–344CrossRefPubMed Nucci F, Artico M, Santoro A, Bardella L, Delfini R, Bosco S, Palma L (1990) Intraneural synovial cyst of the peroneal nerve: report of two cases and review of the literature. Neurosurgery 26:339–344CrossRefPubMed
44.
go back to reference Desy NM, Spinner RJ (2016) Pediatric intraneural ganglia: the value of a systematic review for “orphan” conditions. World Neurosurg 91:658–659.e2CrossRefPubMed Desy NM, Spinner RJ (2016) Pediatric intraneural ganglia: the value of a systematic review for “orphan” conditions. World Neurosurg 91:658–659.e2CrossRefPubMed
45.
go back to reference Spinner RJ et al (2003) Peroneal intraneural ganglia: the importance of the articular branch. Clinical series. J Neurosurg 99(2):319–329CrossRefPubMed Spinner RJ et al (2003) Peroneal intraneural ganglia: the importance of the articular branch. Clinical series. J Neurosurg 99(2):319–329CrossRefPubMed
46.
go back to reference Spinner RJ, Scheithauer BW, Amrami KK, Wenger DE, Hébert-Blouin MN (2012) Adipose lesions of nerve: the need for a modified classification. J Neurosurg 116:418–431CrossRefPubMed Spinner RJ, Scheithauer BW, Amrami KK, Wenger DE, Hébert-Blouin MN (2012) Adipose lesions of nerve: the need for a modified classification. J Neurosurg 116:418–431CrossRefPubMed
47.
go back to reference Maher CO, Spinner RJ, Giannini C, Scheithauer BW, Crum BA (2002) Neuromuscular choristoma of the sciatic nerve. Case report. J Neurosurg 96:1123–1126CrossRefPubMed Maher CO, Spinner RJ, Giannini C, Scheithauer BW, Crum BA (2002) Neuromuscular choristoma of the sciatic nerve. Case report. J Neurosurg 96:1123–1126CrossRefPubMed
48.
go back to reference Ouvrier RA, McLeod JG, Pollard JD (1999) Peripheral neuropathy in childhood, 2nd edn. MacKeith Press, London Ouvrier RA, McLeod JG, Pollard JD (1999) Peripheral neuropathy in childhood, 2nd edn. MacKeith Press, London
49.
go back to reference Moschella SL (2004) An update on the diagnosis and treatment of leprosy. J Am Acad Dermatol 51:417–426CrossRefPubMed Moschella SL (2004) An update on the diagnosis and treatment of leprosy. J Am Acad Dermatol 51:417–426CrossRefPubMed
50.
go back to reference McLeod JG, Hargrave JC, Gye RS et al (1975) Nerve grafting in leprosy. Brain J Neurol 98:203–212CrossRef McLeod JG, Hargrave JC, Gye RS et al (1975) Nerve grafting in leprosy. Brain J Neurol 98:203–212CrossRef
Metadata
Title
Peripheral nerve injuries in the pediatric population: a review of the literature. Part III: peripheral nerve tumors in children
Authors
Javier Robla Costales
Mariano Socolovsky
Jaime A. Sánchez Lázaro
Rubén Álvarez García
David Robla Costales
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 1/2019
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-018-3976-6

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