Skip to main content
Top
Published in: Child's Nervous System 11/2018

01-11-2018 | Original Paper

Guillain-Barré syndrome in children: subtypes and outcome

Authors: Zeynep Selen Karalok, Birce Dilge Taskin, Zeliha Brohi Yanginlar, Esra Gurkas, Alev Guven, Aydan Degerliyurt, Ece Unlu, Gulsen Kose

Published in: Child's Nervous System | Issue 11/2018

Login to get access

Abstract

Objective

This study reviews the clinical features, subtypes, and outcomes of childhood Guillain-Barré syndrome (GBS).

Methods

Fifty-four children who attended a tertiary care training and research hospital in Turkey were enrolled in the study.

Results

The mean age was 6.5 ± 4.2 years and 32 patients (59.5%) were male. The most common subtype of GBS was acute inflammatory demyelinating polyneuropathy (AIDP), which was seen in 27 patients (50%). Having antecedent history, especially upper respiratory tract infection was significantly more common in AIDP (P = 0.028). Sensorial symptoms were significantly more frequent in axonal type GBS (P = 0.001). When we compare the demyelinating and axonal forms, all of the groups had favorable outcome.

Conclusion

The diagnosis of pediatric GBS can be delayed because of its variable presentation. Early admission to hospital and early treatment are important for decreasing the need for respiratory support and improving the outcome.
Literature
1.
go back to reference Hughes RA, Rees JH (1997) Clinical and epidemiological features of Guillain-Barré syndrome. J Infect Dis 176:S92–S98CrossRef Hughes RA, Rees JH (1997) Clinical and epidemiological features of Guillain-Barré syndrome. J Infect Dis 176:S92–S98CrossRef
2.
go back to reference Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KW, Swan AV (1998) Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Ann Neurol 44:780–788CrossRef Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KW, Swan AV (1998) Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Ann Neurol 44:780–788CrossRef
3.
go back to reference Hughes RA, Cornblath DR (2005) Guillain-Barre syndrome. Lancet 366:1653–1666CrossRef Hughes RA, Cornblath DR (2005) Guillain-Barre syndrome. Lancet 366:1653–1666CrossRef
4.
go back to reference McKhann GM, Cornblath DR, Griffin JW, Ho TW, Li CY, Jiang Z et al (1993) Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol 33:333–342CrossRef McKhann GM, Cornblath DR, Griffin JW, Ho TW, Li CY, Jiang Z et al (1993) Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol 33:333–342CrossRef
5.
go back to reference Paradiso G, Tripoli J, Galicchio S, Fejerman N (1999) Epidemiological, clinical, and electrodiagnostic findings in childhood Guillain-Barré syndrome: a reappraisal. Ann Neurol 46:701–707CrossRef Paradiso G, Tripoli J, Galicchio S, Fejerman N (1999) Epidemiological, clinical, and electrodiagnostic findings in childhood Guillain-Barré syndrome: a reappraisal. Ann Neurol 46:701–707CrossRef
6.
go back to reference Ogawara K, Kuwabara S, Mori M, Hattori T, Koga M, Yuki N (2000) Axonal Guillain-Barré syndrome: relation to anti-ganglioside antibodies and Campylobacter jejuni infection in Japan. Ann Neurol 48:624–631CrossRef Ogawara K, Kuwabara S, Mori M, Hattori T, Koga M, Yuki N (2000) Axonal Guillain-Barré syndrome: relation to anti-ganglioside antibodies and Campylobacter jejuni infection in Japan. Ann Neurol 48:624–631CrossRef
7.
go back to reference Asbury AK (2000) New concepts of Guillain-Barre syndrome. J Child Neurol 15:183–191CrossRef Asbury AK (2000) New concepts of Guillain-Barre syndrome. J Child Neurol 15:183–191CrossRef
8.
go back to reference Korinthenberg R, Monting JS (1996) Natural history and treatment effects in Guillain-Barré syndrome: a multicentre study. Arch Dis Child 74:281–287CrossRef Korinthenberg R, Monting JS (1996) Natural history and treatment effects in Guillain-Barré syndrome: a multicentre study. Arch Dis Child 74:281–287CrossRef
9.
go back to reference Abd-Allah SA, Jansen PW, Ashwal S, Perkin RM (1997) Intravenous immunoglobulin as therapy for pediatric Guillain-Barré syndrome. J Child Neurol 12:376–380CrossRef Abd-Allah SA, Jansen PW, Ashwal S, Perkin RM (1997) Intravenous immunoglobulin as therapy for pediatric Guillain-Barré syndrome. J Child Neurol 12:376–380CrossRef
10.
go back to reference Kanra G, Ozon A, Vajsar J, Castagna L, Secmeer G, Topaloglu H (1997) Intravenous immunoglobulin treatment in children with Guillain-Barré syndrome. Eur J Paediatr Neurol 1:7–12CrossRef Kanra G, Ozon A, Vajsar J, Castagna L, Secmeer G, Topaloglu H (1997) Intravenous immunoglobulin treatment in children with Guillain-Barré syndrome. Eur J Paediatr Neurol 1:7–12CrossRef
11.
go back to reference Asbury AK, Cornblath DR (1990) Assessment of current diagnostic criteria for Guillain-Barré syndrome. Ann Neurol 27:21–24CrossRef Asbury AK, Cornblath DR (1990) Assessment of current diagnostic criteria for Guillain-Barré syndrome. Ann Neurol 27:21–24CrossRef
12.
go back to reference Levin KH (2004) Variants and mimics of Guillain-Barré syndrome. Neurologist 10:61–74CrossRef Levin KH (2004) Variants and mimics of Guillain-Barré syndrome. Neurologist 10:61–74CrossRef
13.
go back to reference Bradshaw DY, Jones HR Jr (1992) Guillain-Barré syndrome children: clinical course, electrodiagnosis, and prognosis. Muscle Nerve 15:500–506CrossRef Bradshaw DY, Jones HR Jr (1992) Guillain-Barré syndrome children: clinical course, electrodiagnosis, and prognosis. Muscle Nerve 15:500–506CrossRef
14.
go back to reference Hartung HP, Kieseier BC, Kiefer R (2001) Progress in Guillain-Barré syndrome. Curr Opin Neurol 14:597–604CrossRef Hartung HP, Kieseier BC, Kiefer R (2001) Progress in Guillain-Barré syndrome. Curr Opin Neurol 14:597–604CrossRef
15.
go back to reference Lu JL, Sheikh KA, Wu HS, Zou LP, Zhang WC, Zhaori G et al (2000) Physiologic–pathologic correlation in Guillain–Barré syndrome in children. Neurology 54:33–39CrossRef Lu JL, Sheikh KA, Wu HS, Zou LP, Zhang WC, Zhaori G et al (2000) Physiologic–pathologic correlation in Guillain–Barré syndrome in children. Neurology 54:33–39CrossRef
16.
go back to reference Nagasawa K, Kuwabara S, Misawa S, Fujii K, Tanabe Y, Yuki N, Hattori T, Kohno Y (2006) Electrophysiological subtypes and prognosis of childhood Guillain-Barré syndrome in Japan. Muscle Nerve 33:766–770CrossRef Nagasawa K, Kuwabara S, Misawa S, Fujii K, Tanabe Y, Yuki N, Hattori T, Kohno Y (2006) Electrophysiological subtypes and prognosis of childhood Guillain-Barré syndrome in Japan. Muscle Nerve 33:766–770CrossRef
17.
go back to reference Tekgul H, Serdaroglu G, Tutuncuoglu S (2003) Outcome of axonal and demyelinating forms of Guillain–Barré syndrome in children. Pediatr Neurol 28:295–299CrossRef Tekgul H, Serdaroglu G, Tutuncuoglu S (2003) Outcome of axonal and demyelinating forms of Guillain–Barré syndrome in children. Pediatr Neurol 28:295–299CrossRef
18.
go back to reference Sankhyan N, Sharma S, Konanki R, Gulati S (2014) Childhood Guillain-Barré syndrome subtypes in northern India. J Clin Neurosci 21:427–430CrossRef Sankhyan N, Sharma S, Konanki R, Gulati S (2014) Childhood Guillain-Barré syndrome subtypes in northern India. J Clin Neurosci 21:427–430CrossRef
19.
go back to reference Nachamkin I, Arzarte Barbosa P, Ung H, Lobato C, Gonzalez Rivera A, Rodriguez P, Garcia Briseno A, Cordero LM, Garcia Perea L, Perez JC, Ribera M, Aldama PC, Guitérrez GD, Sarnat LF, García MR, Veitch J, Fitzgerald C, Cornblath DR, Rodriguez Pinto M, Griffin JW, Willison HJ, Asbury AK, McKhann G (2007) Patterns of Guillain-Barre syndrome in children: results from a Mexican population. Neurology 69:1665–1671CrossRef Nachamkin I, Arzarte Barbosa P, Ung H, Lobato C, Gonzalez Rivera A, Rodriguez P, Garcia Briseno A, Cordero LM, Garcia Perea L, Perez JC, Ribera M, Aldama PC, Guitérrez GD, Sarnat LF, García MR, Veitch J, Fitzgerald C, Cornblath DR, Rodriguez Pinto M, Griffin JW, Willison HJ, Asbury AK, McKhann G (2007) Patterns of Guillain-Barre syndrome in children: results from a Mexican population. Neurology 69:1665–1671CrossRef
20.
go back to reference Lin JJ, Hsia SH, Wang HS, Lyu RK, Chou ML, Hung PC, Hsieh MY, Lin KL (2012) Clinical variants of Guillain-Barré syndrome in children. Pediatr Neurol 47:91–96CrossRef Lin JJ, Hsia SH, Wang HS, Lyu RK, Chou ML, Hung PC, Hsieh MY, Lin KL (2012) Clinical variants of Guillain-Barré syndrome in children. Pediatr Neurol 47:91–96CrossRef
21.
go back to reference Hiraga A, Mori M, Ogawara K, Kojima S, Kanesaka T, Misawa S, Hattori T, Kuwabara S (2005) Recovery patterns and long term prognosis for axonal Guillain–Barré syndrome. J Neurol Neurosurg Psychiatry 76:719–722CrossRef Hiraga A, Mori M, Ogawara K, Kojima S, Kanesaka T, Misawa S, Hattori T, Kuwabara S (2005) Recovery patterns and long term prognosis for axonal Guillain–Barré syndrome. J Neurol Neurosurg Psychiatry 76:719–722CrossRef
22.
go back to reference Ryan MM (2013) Pediatric Guillain-Barré syndrome. Curr Opin Pediatr 25:689–693CrossRef Ryan MM (2013) Pediatric Guillain-Barré syndrome. Curr Opin Pediatr 25:689–693CrossRef
23.
go back to reference Mulkey SB, Glasier CM, El-Nabbout B, Walters WD, Ionita C, McCarthy MH et al (2010) Nerve root enhancement on spinal MRI in pediatric Guillain-Barré syndrome. Pediatr Neurol 43:263–269CrossRef Mulkey SB, Glasier CM, El-Nabbout B, Walters WD, Ionita C, McCarthy MH et al (2010) Nerve root enhancement on spinal MRI in pediatric Guillain-Barré syndrome. Pediatr Neurol 43:263–269CrossRef
24.
go back to reference Zuccoli G, Panigrahy A, Bailey A, Fitz C (2011) Redefining the Guillain-Barré spectrum in children: neuroimaging findings of cranial nerve involvement. Am J Neuroradiol 32:639–642CrossRef Zuccoli G, Panigrahy A, Bailey A, Fitz C (2011) Redefining the Guillain-Barré spectrum in children: neuroimaging findings of cranial nerve involvement. Am J Neuroradiol 32:639–642CrossRef
25.
go back to reference Korinthenberg R, Schessl J, Kirschner J (2007) Clinical presentation and course of childhood Guillain-Barré syndrome: a prospective multicentre study. Neuropediatrics 38:10–17CrossRef Korinthenberg R, Schessl J, Kirschner J (2007) Clinical presentation and course of childhood Guillain-Barré syndrome: a prospective multicentre study. Neuropediatrics 38:10–17CrossRef
26.
go back to reference Dimario FJ Jr, Edwards C (2012) Autonomic dysfunction in childhood Guillain-Barré syndrome. J Child Neurol 27:581–586CrossRef Dimario FJ Jr, Edwards C (2012) Autonomic dysfunction in childhood Guillain-Barré syndrome. J Child Neurol 27:581–586CrossRef
27.
go back to reference Cooper WO, Daniels SR, Loggie JMH (1998) Prevalence and correlates of blood pressure elevation in children with Guillain-Barré syndrome. Clin Pediatr 37:621–625CrossRef Cooper WO, Daniels SR, Loggie JMH (1998) Prevalence and correlates of blood pressure elevation in children with Guillain-Barré syndrome. Clin Pediatr 37:621–625CrossRef
28.
go back to reference de Jager AE, Sluiter HJ (1991) Clinical signs in severe Guillain-Barré syndrome: analysis of 63 patients. J Neurol Sci 104:143–150CrossRef de Jager AE, Sluiter HJ (1991) Clinical signs in severe Guillain-Barré syndrome: analysis of 63 patients. J Neurol Sci 104:143–150CrossRef
29.
go back to reference Flachenecker P, Wermuth P, Hartung HP, Reiners K (1997) Quantitative assessment of cardiovascular autonomic function in Guillain-Barré syndrome. Ann Neurol 42:171–179CrossRef Flachenecker P, Wermuth P, Hartung HP, Reiners K (1997) Quantitative assessment of cardiovascular autonomic function in Guillain-Barré syndrome. Ann Neurol 42:171–179CrossRef
30.
go back to reference Samadi M, Kazemi B, Golzari Oskoui S, Barzegar M (2013) Assessment of autonomic dysfunction in childhood Guillain-Barré syndrome. J Cardiovasc Thorac Res 5:81–85PubMedPubMedCentral Samadi M, Kazemi B, Golzari Oskoui S, Barzegar M (2013) Assessment of autonomic dysfunction in childhood Guillain-Barré syndrome. J Cardiovasc Thorac Res 5:81–85PubMedPubMedCentral
31.
go back to reference Samoĭlovich EO, Ermolovich MA, Kotova IF, Svirchevskaia E, Shimanovich VP, Kozhemiakin AK et al (2007) Surveillance of acute flaccid paralysis in Belarus. Zh Mikrobiol Epidemiol Immunobiol 2:24–31 Samoĭlovich EO, Ermolovich MA, Kotova IF, Svirchevskaia E, Shimanovich VP, Kozhemiakin AK et al (2007) Surveillance of acute flaccid paralysis in Belarus. Zh Mikrobiol Epidemiol Immunobiol 2:24–31
32.
go back to reference Yuki N, Yoshino H, Sato S, Miyatake T (1990) Acute axonal polyneuropathy associated with anti-GM1 antibodies following Campylobacter enteritis. Neurology 40:1900–1902CrossRef Yuki N, Yoshino H, Sato S, Miyatake T (1990) Acute axonal polyneuropathy associated with anti-GM1 antibodies following Campylobacter enteritis. Neurology 40:1900–1902CrossRef
33.
go back to reference Feasby TE, Gilbert JJ, Brown WF, Bolton CF, Gilbert JJ, Koop-man WJ (1986) An acute axonal form of Guillain–Barrée polyneuropathy. Brain 109:1115–1126CrossRef Feasby TE, Gilbert JJ, Brown WF, Bolton CF, Gilbert JJ, Koop-man WJ (1986) An acute axonal form of Guillain–Barrée polyneuropathy. Brain 109:1115–1126CrossRef
34.
go back to reference Ho TW, Li CY, Cornblath DR, Gao CY, Asbury AK, Griffin JW (1997) Patterns of recovery in the Guillain–Barré syndromes. Neurology 48:717–724CrossRef Ho TW, Li CY, Cornblath DR, Gao CY, Asbury AK, Griffin JW (1997) Patterns of recovery in the Guillain–Barré syndromes. Neurology 48:717–724CrossRef
35.
go back to reference Kuwabara S, Asahina M, Koga M, Mori M, Yuki N, Hattori T (1998) Two patterns of clinical recovery in Guillain–Barré syndrome with IgG anti-GM1 antibody. Neurology 51:1656–1660CrossRef Kuwabara S, Asahina M, Koga M, Mori M, Yuki N, Hattori T (1998) Two patterns of clinical recovery in Guillain–Barré syndrome with IgG anti-GM1 antibody. Neurology 51:1656–1660CrossRef
36.
go back to reference Asbury AK, Cornblath DR (1990) Assessment of current diagnostic criteria for Guillain-Barré syndrome. Ann Neurol 27:21–24CrossRef Asbury AK, Cornblath DR (1990) Assessment of current diagnostic criteria for Guillain-Barré syndrome. Ann Neurol 27:21–24CrossRef
Metadata
Title
Guillain-Barré syndrome in children: subtypes and outcome
Authors
Zeynep Selen Karalok
Birce Dilge Taskin
Zeliha Brohi Yanginlar
Esra Gurkas
Alev Guven
Aydan Degerliyurt
Ece Unlu
Gulsen Kose
Publication date
01-11-2018
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 11/2018
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-018-3856-0

Other articles of this Issue 11/2018

Child's Nervous System 11/2018 Go to the issue