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Child's Nervous System
Published in: Child's Nervous System 11/2018

01-11-2018 | Case Report

Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma

Authors: Kenji Miyata, Toshinori Hori, Yasuto Shimomura, Masahiro Joko, Masakazu Takayasu, Akihisa Okumura

Published in: Child's Nervous System | Issue 11/2018

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Abstract

Clinical case

We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings.

Conclusion

This case highlights the efficacy and tolerability of bevacizumab for the treatment of pseudoprogression in children with spinal low-grade gliomas.
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Metadata
Title
Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma
Authors
Kenji Miyata
Toshinori Hori
Yasuto Shimomura
Masahiro Joko
Masakazu Takayasu
Akihisa Okumura
Publication date
01-11-2018
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 11/2018
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-018-3841-7

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