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Child's Nervous System
Published in: Child's Nervous System 7/2016

01-07-2016 | Case Report

Langerhans cell histiocytosis with seborrheic eczema of the scalp and extensive calvarial involvement

Authors: Satoshi Tsutsumi, Shintaro Nakajima, Hisayuki Oda, Yukimasa Yasumoto

Published in: Child's Nervous System | Issue 7/2016

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Abstract

Introduction

Langerhans cell histiocytosis (LCH) is a multisystem disorder of unknown etiology and characterized by accumulation of histiocytes in various tissues.

Case report

A 3-year-old, previously healthy girl presented with progressive flattening of the parietal convexity for 6 months and seborrheic eczema of the scalp. At presentation, the patient showed no neurological deficit. The eczemas were extensively distributed over the scalp, but not found in any other site of the body. Blood examination revealed a marked increase in soluble interleukin-2 receptor levels. Neuroimages revealed multiple calvarial defects that were replaced by well-demarcated, enhancing extracerebral masses. A biopsy surgery confirmed the diagnosis as LCH.

Conclusion

LCH may cause progressive calvarial defects. If seborrheic eczemas are concurrent, they may suggest prompt histological verification and treatments be initiated.
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Metadata
Title
Langerhans cell histiocytosis with seborrheic eczema of the scalp and extensive calvarial involvement
Authors
Satoshi Tsutsumi
Shintaro Nakajima
Hisayuki Oda
Yukimasa Yasumoto
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 7/2016
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-016-3026-1

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