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Child's Nervous System
Published in: Child's Nervous System 12/2014

01-12-2014 | Case Report

Fetal intracranial hemorrhage related to maternal autoimmune thrombocytopenic purpura

Authors: Mehmet Serdar Kutuk, Laure Croisille, Sureyya Burcu Gorkem, Ebru Yilmaz, Levent Korkmaz, Philippe Bierling, Ekrem Unal

Published in: Child's Nervous System | Issue 12/2014

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Abstract

Background

Maternal autoimmune thrombocytopenic purpura (AITP) can cause fetal intracranial hemorrhage.

Case report

A 19-year-old primigravida was referred to our institution for prenatally detected ventriculomegaly at 30th week of gestation. Her personal and family histories were unremarkable. Her platelet count was 54 × 109/L. Fetal neurosonography showed intraparenchymal hemorrhage. AITP was diagnosed in the mother and platelet count decreased at 34 × 109/L. Patient was treated with methylprednisolone and intravenous immunoglobulin. She delivered a 2,340-g infant at 37 weeks with elective cesarean section. The platelet count of the newborn was 181 × 109/L and coagulation tests were normal. No antiplatelet specific antibodies were detected in cord blood. Postnatal MRI evaluation confirmed grade IV intracranial hemorrhage. The newborn baby has suffered from mild spasticity and seizures.

Conclusions

Clinicians must be vigilant about the catastrophic fetal complications of maternal AITP; a close follow-up with a multidisciplinary cooperation between obstetricians, hematologists, and neonatologists must be warranted.
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Metadata
Title
Fetal intracranial hemorrhage related to maternal autoimmune thrombocytopenic purpura
Authors
Mehmet Serdar Kutuk
Laure Croisille
Sureyya Burcu Gorkem
Ebru Yilmaz
Levent Korkmaz
Philippe Bierling
Ekrem Unal
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 12/2014
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-014-2473-9

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