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Child's Nervous System
Published in: Child's Nervous System 3/2014

01-03-2014 | Original Paper

Childhood central nervous system tumors at MAHAK’s Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran

Authors: Azim Mehrvar, Mohammad Faranoush, Amir Abbas Hedayati Asl, Maryam Tashvighi, Mohammad Ali Fazeli, Ibrahim Qaddoumi, Narjes Mehrvar, Behdad Sobuti, Ali Jafarpour, Reza Ravan parsa, Rokhsaneh Zangooei, Mardawig Alebouyeh, Parvaneh Vossough

Published in: Child's Nervous System | Issue 3/2014

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Abstract

Purpose

As central nervous system (CNS) tumors account for second most common childhood malignancies and the first cause of mortality in children with cancer, improving treatment modalities can lead to increase the health care of patients. In this study, we examined the prevalence of childhood brain tumors in patients who referred to MAHAK’s Pediatric Cancer Treatment and Research Center (MPCTRC) for treatment.

Methods

A retrospective review of all children less than 15 years old with a CNS histologically proven tumor, who presented to MPCTRC from April 2007 to April 2010, was performed. Data was analyzed by SPSS version 19 with Kolmogorov–Smirnov and Chi-square tests.

Results

There were 198 (124 boys) children eligible for the study. The majority of the tumors were infratentorial (n = 134), and the rest were supratentorial (n = 60) and spinal (n = 4) cases. The median age was 6.11 ± 3.65 years old. Medulloblastoma (n = 66), low-grade glioma (n = 52), and high-grade glioma (n = 40) were the most common tumors. The mean duration of follow-up was 21 months. At the time of this analysis, there were 105 (53 %) children alive, 82 (41.4 %) deaths, and 11 (5.6 %) lost for follow-up. The survival rate was 51.68 ± 5.22 %.

Conclusions

In contrast of high rate of death in this study, other general characteristics can serve as benchmark for improving our care for children with brain tumors in Iran.
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Metadata
Title
Childhood central nervous system tumors at MAHAK’s Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran
Authors
Azim Mehrvar
Mohammad Faranoush
Amir Abbas Hedayati Asl
Maryam Tashvighi
Mohammad Ali Fazeli
Ibrahim Qaddoumi
Narjes Mehrvar
Behdad Sobuti
Ali Jafarpour
Reza Ravan parsa
Rokhsaneh Zangooei
Mardawig Alebouyeh
Parvaneh Vossough
Publication date
01-03-2014
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 3/2014
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-013-2256-8

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