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01-11-2013 | Original Paper

Histologic grade and extent of resection are associated with survival in pediatric spinal cord ependymomas

Authors: Michael Safaee, Michael C. Oh, Joseph M. Kim, Derick Aranda, Phiroz E. Tarapore, Tene A. Cage, Nalin Gupta, Andrew T. Parsa

Published in: Child's Nervous System | Issue 11/2013

Abstract

Purpose

Prognostic factors affecting outcomes in pediatric spinal cord ependymomas are limited. We sought to investigate potential associations between extent of resection and histologic grade on progression-free survival (PFS) and overall survival (OS).

Methods

A comprehensive literature search was performed to identify pediatric patients who underwent surgical resection for spinal cord ependymomas. Only manuscripts with clearly defined age, tumor grade, extent of resection, and clinical follow-up were included.

Results

A total of 80 patients were identified with a histologic distribution as follows: 36 % myxopapillary (grade I), 54 % classical (grade II), and 10 % anaplastic (grade III). There was no association between tumor grade and PFS. The only factor associated with improved PFS was gross total resection (GTR), which remained significant in a multivariate model (hazard ratio (HR) = 0.248, p = 0.022). Moreover, older age (HR = 0.818, p = 0.026), GTR (HR = 0.042, p = 0.013), and anaplastic grade (HR = 19.847, p = 0.008) demonstrated a significant association with OS in a multivariate model.

Conclusions

Among pediatric patients with spinal cord ependymomas, PFS did not differ across histologic grades but was prolonged among patients who underwent GTR. Age, extent of resection, and tumor grade were all significantly associated with survival.

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Title: Histologic grade and extent of resection are associated with survival in pediatric spinal cord ependymomas
Authors: Michael Safaee
Michael C. Oh
Joseph M. Kim
Derick Aranda
Phiroz E. Tarapore
Tene A. Cage
Nalin Gupta
Andrew T. Parsa
Publication date: 01-11-2013
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 11/2013
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-013-2149-x

At a glance: The STEP trials

Springer Medicine

Histologic grade and extent of resection are associated with survival in pediatric spinal cord ependymomas

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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