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Child's Nervous System

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01-03-2013 | Review Paper

Paediatric spinal glioblastoma: case report and review of therapeutic strategies

Authors: Philip J. O’Halloran, Michael Farrell, John Caird, Michael Capra, David O’Brien

Published in: Child's Nervous System | Issue 3/2013

Abstract

Introduction

Although uncommon, there is significant morbidity and mortality associated with paediatric spinal glioblastoma. The paucity of cases makes treatment options difficult. The current recommended standard of care is biopsy followed by adjuvant chemo-radiotherapy, with emerging data supporting the role of safe gross total resection.

Objective

The purpose of this paper is to provide a single-institution case study and to discuss current and future therapeutic treatment strategies.

Case presentation

A 14-year-old boy presented with a 2-year history of intermittent back pain with recent progressively worsening motor and sensory deficits of the right side. Pre-operative MRI revealed an enhancing intra-medullary tumour extending from C2 to C7. During the operative case, no tumour–cord margin could be identified, and the patient underwent a subtotal excision. Histopathology confirmed glioblastoma. In the subsequent weeks, the patient's clinical condition deteriorated. Adjuvant therapy was declined by the family, and the patient died 9 weeks after initial presentation.

Conclusion

Despite major advances in surgical techniques, peri-operative neuro-imaging as well as chemo-radiotherapy, the prognosis of a paediatric intra-medullary high-grade spinal tumour remains poor. Detailed analysis of our understanding of tumour dynamics in this patient group is important in establishing future therapeutic strategies.

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Title: Paediatric spinal glioblastoma: case report and review of therapeutic strategies
Authors: Philip J. O’Halloran
Michael Farrell
John Caird
Michael Capra
David O’Brien
Publication date: 01-03-2013
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 3/2013
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-013-2023-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Paediatric spinal glioblastoma: case report and review of therapeutic strategies

Abstract

Introduction

Objective

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Objective

Case presentation

Conclusion

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