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Published in: Child's Nervous System 6/2011

01-06-2011 | Original Paper

Neuroendoscopy in the management of pineal tumors

Authors: Tai-Tong Wong, Hsin-Hung Chen, Muh-Lii Liang, Yu-Shu Yen, Feng-Chi Chang

Published in: Child's Nervous System | Issue 6/2011

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Abstract

Introduction

Endoscopy has been applied for the management of pineal tumors and the associated obstructive hydrocephalus. The techniques include endoscopic third ventriculostomy (ETV), endoscopic biopsy, and endoscopic-assisted open surgery of tumor in selected cases. The purpose of this study is to report our experience and techniques of endoscopic surgeries for pineal tumors in children.

Methods

This is a retrospective review of 36 ETVs, 25 endoscopic transventricular biopsies (ETB), 2 endoscopic transnasal transsphenoid biopsies, and 5 endoscopic-assisted open resections of pineal tumors.

Results

One patient died of delay tumor hemorrhage after ETV and ETB were excluded. With a mean follow-up period of 5.4 years, ETV failure occurred in 7 of 35 patients with long-term success rate of 80.0%. Histological diagnosis was established in 21 of 25 (84.0%) patients through ETBs. Tissue diagnosis was obtained in two selected patients with bifocal germ cell tumors by endsocopic transnasal transsphenoid approach to the intrasellar lesion. Direct radical resections were achieved in four of five selected patients of pineal tumors with hydrocephalus by endoscopic-assisted open surgery.
Literature
1.
go back to reference Baskin DS, Wilson CB (1983) Transsphenoidal surgery of intrasellar germinomas: reported of two cases. J Neurosurg 59(6):1063–1066PubMedCrossRef Baskin DS, Wilson CB (1983) Transsphenoidal surgery of intrasellar germinomas: reported of two cases. J Neurosurg 59(6):1063–1066PubMedCrossRef
2.
go back to reference Bruce JN, Ogden AT (2004) Surgical strategies for treating patients with pineal region tumors. J Neurooncol 69(1–3):221–236PubMedCrossRef Bruce JN, Ogden AT (2004) Surgical strategies for treating patients with pineal region tumors. J Neurooncol 69(1–3):221–236PubMedCrossRef
3.
go back to reference Chermov MF, Kamikawa S, Fumitaka Y, Shoichiro I, Osami K, Tomokatsue H (2006) Neurofibersocopic biopsy of tumors of the pineal region and posterior third ventricle: indications, technique, complications, and results. Neurosurgery 59(2):267–277CrossRef Chermov MF, Kamikawa S, Fumitaka Y, Shoichiro I, Osami K, Tomokatsue H (2006) Neurofibersocopic biopsy of tumors of the pineal region and posterior third ventricle: indications, technique, complications, and results. Neurosurgery 59(2):267–277CrossRef
4.
go back to reference Drummond KJ, Rosenfeld JV (1999) Pineal region tumors in childhood. A 30-year experience. Childs Nerv Syst 15(2–3):119–126PubMedCrossRef Drummond KJ, Rosenfeld JV (1999) Pineal region tumors in childhood. A 30-year experience. Childs Nerv Syst 15(2–3):119–126PubMedCrossRef
5.
go back to reference de Divitiis, Cappabianca P, Gangemi M, Cavallo LM (2000) The role of endoscopic transsphenoidal approach in pediatric neurosurgery. Child’s Nerv Syst 16:692–695CrossRef de Divitiis, Cappabianca P, Gangemi M, Cavallo LM (2000) The role of endoscopic transsphenoidal approach in pediatric neurosurgery. Child’s Nerv Syst 16:692–695CrossRef
6.
go back to reference Depreitere B, Dasi N, Rutka J, Dirks P, Drake J (2007) Endoscopic biopsy for intraventricular tumors in children. J Neurosurg 106(5 Suppl):340–346PubMed Depreitere B, Dasi N, Rutka J, Dirks P, Drake J (2007) Endoscopic biopsy for intraventricular tumors in children. J Neurosurg 106(5 Suppl):340–346PubMed
7.
go back to reference Di Rocco C, Cinalli G, Massimi L, Spennato P, Cianciulli E, Tamburini G (2006) Endoscopic third ventriculostomy in the treatment of hydrocephalus in pediatric patients. Adv Tech Stand Neurosurg 31:119–219PubMedCrossRef Di Rocco C, Cinalli G, Massimi L, Spennato P, Cianciulli E, Tamburini G (2006) Endoscopic third ventriculostomy in the treatment of hydrocephalus in pediatric patients. Adv Tech Stand Neurosurg 31:119–219PubMedCrossRef
8.
go back to reference Di Rocco F, Oi S, Samii A, Paterno V, Feigl GC, Ludermann W, Samii M (2007) Neuronavigational endoscopic endonasal sellar and parasellar surgery using a 2-mm-diameter lens rigid-rod endoscope: a cadaver study. Neurosurgery (ONS Suppl 2):ONS394–400 Di Rocco F, Oi S, Samii A, Paterno V, Feigl GC, Ludermann W, Samii M (2007) Neuronavigational endoscopic endonasal sellar and parasellar surgery using a 2-mm-diameter lens rigid-rod endoscope: a cadaver study. Neurosurgery (ONS Suppl 2):ONS394–400
9.
go back to reference Haw C, Steinbok P (2001) Ventriculoscope tract recurrence after endoscopic biopsy of pineal germinoma. Pediatr Neurosurg 34(4):215–217PubMedCrossRef Haw C, Steinbok P (2001) Ventriculoscope tract recurrence after endoscopic biopsy of pineal germinoma. Pediatr Neurosurg 34(4):215–217PubMedCrossRef
10.
go back to reference Hellwig D, Grotenhuis JA, Tirakotai W, Riegel T, Schulte DM, Bauer BL, Bertalanffy H (2005) Endoscopic third ventriculostomy for obstructive hydrocephalus. Neurosurg Rev 28(1):1–3PubMed Hellwig D, Grotenhuis JA, Tirakotai W, Riegel T, Schulte DM, Bauer BL, Bertalanffy H (2005) Endoscopic third ventriculostomy for obstructive hydrocephalus. Neurosurg Rev 28(1):1–3PubMed
11.
go back to reference Huang PI, Chen YW, Wong TT, Lee YY, Chang KP, Guo WY, Chang FC, Liang ML, Chen HH, Chiou SH, Yen SH (2008) Extended focal radiotherapy of 30 GY alone for intracranial synchronous bifocal germinoma: a single institute experience. Childs Nerv Syst 24(11):1315–1321PubMedCrossRef Huang PI, Chen YW, Wong TT, Lee YY, Chang KP, Guo WY, Chang FC, Liang ML, Chen HH, Chiou SH, Yen SH (2008) Extended focal radiotherapy of 30 GY alone for intracranial synchronous bifocal germinoma: a single institute experience. Childs Nerv Syst 24(11):1315–1321PubMedCrossRef
12.
go back to reference Konovalov AN, Pitskhelauri DI (2003) Principles of treatment of the pineal region tumors. Surg Neurol 59(4):250–268PubMedCrossRef Konovalov AN, Pitskhelauri DI (2003) Principles of treatment of the pineal region tumors. Surg Neurol 59(4):250–268PubMedCrossRef
13.
go back to reference Nomura K (2001) Epidemiology of germ cell tumors in Asia of pineal region tumor. J Neurooncol 54(3):211–217PubMedCrossRef Nomura K (2001) Epidemiology of germ cell tumors in Asia of pineal region tumor. J Neurooncol 54(3):211–217PubMedCrossRef
14.
go back to reference O’Brien DF, Hayhurst C, Pizer B, Mallucci CL (2006) Outcomes in patients undergoing single-trajectory endoscopic third ventriculostomy and endoscopic biopsy for midline tumors presenting with obstructive hydrocephalus. J Neurosurg 105(3 Suppl Pediatrics):219–226PubMed O’Brien DF, Hayhurst C, Pizer B, Mallucci CL (2006) Outcomes in patients undergoing single-trajectory endoscopic third ventriculostomy and endoscopic biopsy for midline tumors presenting with obstructive hydrocephalus. J Neurosurg 105(3 Suppl Pediatrics):219–226PubMed
15.
go back to reference Oi S, Kamio M, Joki T, Abe T (2001) Neuroendoscopic anatomy and surgery in pineal region tumors: role of neuroendoscopic procedure in the ‘minimally- invasive preferential’ management. J Neurooncol 54(3):277–286PubMedCrossRef Oi S, Kamio M, Joki T, Abe T (2001) Neuroendoscopic anatomy and surgery in pineal region tumors: role of neuroendoscopic procedure in the ‘minimally- invasive preferential’ management. J Neurooncol 54(3):277–286PubMedCrossRef
16.
go back to reference Oi S, Matsuzawa K, Choi JU, Kim DS, Kang JK, Cho BK (1998) Identical characteristics of the patient populations with pineal region tumors in Japan and in Korea and therapeutic modalities. Childs Nerv Syst 14(102):36–40PubMedCrossRef Oi S, Matsuzawa K, Choi JU, Kim DS, Kang JK, Cho BK (1998) Identical characteristics of the patient populations with pineal region tumors in Japan and in Korea and therapeutic modalities. Childs Nerv Syst 14(102):36–40PubMedCrossRef
17.
go back to reference Pople IK, Athanasiou TC, Sandeman DR, Coakham HB (2001) The role of endoscopicbiopsy and third ventriculostomy in the management of pineal region tumours. Br J Neurosurg 15:305–311PubMedCrossRef Pople IK, Athanasiou TC, Sandeman DR, Coakham HB (2001) The role of endoscopicbiopsy and third ventriculostomy in the management of pineal region tumours. Br J Neurosurg 15:305–311PubMedCrossRef
18.
go back to reference Schild SE, Scheithauer BW, Haddock MG, Wong WW, Lyons MK, Marks LB, Nroman MG, Burger PC (1996) Histlogically confirmed pineal tumors and other germ cell tumors of the brain. Cancer 78(12):2564–2571PubMedCrossRef Schild SE, Scheithauer BW, Haddock MG, Wong WW, Lyons MK, Marks LB, Nroman MG, Burger PC (1996) Histlogically confirmed pineal tumors and other germ cell tumors of the brain. Cancer 78(12):2564–2571PubMedCrossRef
19.
go back to reference Shin HJ, Cho BK, Jung HW, Wang KC (1998) Pediatric pineal tumors: need for a direct surgical approach and complications of the occipital transtentorial approach. Childs Nerv Syst 14(4–5):174–178PubMedCrossRef Shin HJ, Cho BK, Jung HW, Wang KC (1998) Pediatric pineal tumors: need for a direct surgical approach and complications of the occipital transtentorial approach. Childs Nerv Syst 14(4–5):174–178PubMedCrossRef
20.
go back to reference Shirane R, Shamoto H, Umezawa K, Su CC, Kumabe T, Jokura H, Yoshimoto (1999) Surgical treatment of pineal tumors through the occipital transtentorial approach: evaluation of the effectiveness of intraoperative microendoscope combined with neuronavigation. Acta Neurochir (Wien) 141:801–809CrossRef Shirane R, Shamoto H, Umezawa K, Su CC, Kumabe T, Jokura H, Yoshimoto (1999) Surgical treatment of pineal tumors through the occipital transtentorial approach: evaluation of the effectiveness of intraoperative microendoscope combined with neuronavigation. Acta Neurochir (Wien) 141:801–809CrossRef
21.
go back to reference Wellson JC, Reddy AT, Tubbs ST, Abdullatif H (2004) Neuroendoscopic findings in patients with intracranial germinomas correlating with diabetes insipidus. J Neurosurg 100(5 Suppl Pediatrics):430–436 Wellson JC, Reddy AT, Tubbs ST, Abdullatif H (2004) Neuroendoscopic findings in patients with intracranial germinomas correlating with diabetes insipidus. J Neurosurg 100(5 Suppl Pediatrics):430–436
22.
go back to reference Wong TT, Ho DM, Chang KP, Yen SH, Guo WY, Chang FC, Liang ML, Pan HC, Chung WY (2005) Primary pediatric brain tumors: statistics of Taipei VGH, Taiwan (1975–2004). Cancer 104(10):2156–2167PubMedCrossRef Wong TT, Ho DM, Chang KP, Yen SH, Guo WY, Chang FC, Liang ML, Pan HC, Chung WY (2005) Primary pediatric brain tumors: statistics of Taipei VGH, Taiwan (1975–2004). Cancer 104(10):2156–2167PubMedCrossRef
23.
go back to reference Wong TT, Lee LS (1996) A method of enlarging the opening of the third ventricular floor for flexible endoscopic third ventriculostomy. Childs Nerv Syst 12(7):396–398PubMedCrossRef Wong TT, Lee LS (1996) A method of enlarging the opening of the third ventricular floor for flexible endoscopic third ventriculostomy. Childs Nerv Syst 12(7):396–398PubMedCrossRef
24.
go back to reference Wong TT, Yen SH, Ho DM, Chang FC, Chang KP (2003) Pineal germinoma with intratumoral hemorrhage after neuroendoscopic tumor biopsy. Childs Nerv Syst 19:769–772PubMedCrossRef Wong TT, Yen SH, Ho DM, Chang FC, Chang KP (2003) Pineal germinoma with intratumoral hemorrhage after neuroendoscopic tumor biopsy. Childs Nerv Syst 19:769–772PubMedCrossRef
25.
go back to reference Villani R, Papagno C, Tomei G, Grimoldi N, Spagnoli D, Bello L (1997) Transcallosal approach to tumors of the third ventricle. Surgical results and neuropsychological evaluation. J Neurol Sci 41(1):41–50 Villani R, Papagno C, Tomei G, Grimoldi N, Spagnoli D, Bello L (1997) Transcallosal approach to tumors of the third ventricle. Surgical results and neuropsychological evaluation. J Neurol Sci 41(1):41–50
26.
go back to reference Yamini B, Refai D, Rubin CM, Frim DM (2004) Initial endoscopic management of pineal region tumors and associated hydrocephalus: clinical series and literature review. J Neurosurg 100(5 Suppl Pediatrics):437–441PubMed Yamini B, Refai D, Rubin CM, Frim DM (2004) Initial endoscopic management of pineal region tumors and associated hydrocephalus: clinical series and literature review. J Neurosurg 100(5 Suppl Pediatrics):437–441PubMed
Metadata
Title
Neuroendoscopy in the management of pineal tumors
Authors
Tai-Tong Wong
Hsin-Hung Chen
Muh-Lii Liang
Yu-Shu Yen
Feng-Chi Chang
Publication date
01-06-2011
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 6/2011
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-010-1325-5

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