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Child's Nervous System

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01-02-2010 | Focus Session

Clinical applications of biomarkers in pediatric traumatic brain injury

Authors: Simon J. I. Sandler, Anthony A. Figaji, P. David Adelson

Published in: Child's Nervous System | Issue 2/2010

Abstract

Introduction

The diagnosis, treatment, and prediction of outcome in pediatric traumatic brain injury (TBI) present significant challenges to the treating clinician. Clinical and radiological tools for assessing injury severity and predicting outcome, in particular, lack sensitivity and specificity. In patients with mild TBI, often there is uncertainty about which patients should undergo radiological imaging and who is at risk for long term neurological sequelae. In severe TBI, often there is uncertainty about which patients will experience secondary insults and what the outcome for individual patients will be. In several other clinical specialties, biomarkers are used to diagnose disease, direct treatment, and prognosticate. However, an ideal biomarker for brain injury has not been found.

Methods

In this review, we examine the various factors that must be taken into account in the search for a reliable biomarker in brain injury. We review the important studies that have investigated common biomarkers of structural brain injury, in particular S100B, neuron-specific enolase, myelin basic protein, and glial fibrillary acid protein.

Discussion

The potential uses and limitations of these biomarkers in the context of TBI are discussed.

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Title: Clinical applications of biomarkers in pediatric traumatic brain injury
Authors: Simon J. I. Sandler
Anthony A. Figaji
P. David Adelson
Publication date: 01-02-2010
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 2/2010
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-009-1009-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical applications of biomarkers in pediatric traumatic brain injury

Abstract

Introduction

Methods

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Discussion

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