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Child's Nervous System

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01-03-2010 | Original Paper

Neurological complications of neuroblastic tumors: experience of a single center

Authors: G. Burca Aydin, M. Tezer Kutluk, Munevver Buyukpamukcu, Canan Akyuz, Bilgehan Yalcin, Ali Varan

Published in: Child's Nervous System | Issue 3/2010

Abstract

Aim

This study aims to evaluate the prevalence and clinical characteristics of neurological complications in patients with newly diagnosed neuroblastic tumors (NT).

Patients and method

Hospital file search was performed in patients with NT, and neurological complications, clinical, and treatment features were analyzed.

Results

Out of 523 patients with NT, 19 patients had Horner's syndrome, 9 patients had opsoclonus-myoclonus-ataxia syndrome (OMA), 11 patients had central nervous system (CNS) involvement, and 49 patients had spinal cord compression (SCC) at diagnosis. During follow-up, seven more patients had CNS metastases. Survival rates were poor in patients with CNS involvement; all died at a median of 7.9 months after diagnosis. The neurological symptoms and signs of patients with SCC were mild, moderate, and severe in 13, 9, and 22 patients, respectively. Sphincter deficiency and sensory loss were diagnosed in 52.3% and 43.2% of patients. The neurological deficits of 11/17 patients who had symptoms less than 4 weeks were completely resolved or improved. The incidence of sequelae after laminectomy, radiotherapy, and chemotherapy were 46.2%, 66.6%, and 13.6%, respectively.

Conclusion

The prevalence rates of Horner's syndrome, OMA, CNS metastasis, and SCC were found to be 3.6%, 1.8%, 2.2%, and 9.4%, respectively. Metastasis to the CNS indicated a very poor prognosis. No differences in neurological improvement in patients with SCC were found between those treated with radiotherapy, laminectomy, or chemotherapy alone, but laminectomy and radiotherapy caused significant late sequelae. Early diagnosis and proper management is critical to avoid long-term sequelae in patients with SCC.

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Title: Neurological complications of neuroblastic tumors: experience of a single center
Authors: G. Burca Aydin
M. Tezer Kutluk
Munevver Buyukpamukcu
Canan Akyuz
Bilgehan Yalcin
Ali Varan
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 3/2010
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-009-0979-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Neurological complications of neuroblastic tumors: experience of a single center

Abstract

Aim

Patients and method

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Aim

Patients and method

Results

Conclusion

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