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Child's Nervous System
Published in: Child's Nervous System 5/2009

01-05-2009 | Case Report

Thyroid neoplasm after central nervous system irradiation for medulloblastoma in childhood: report of two cases

Authors: Benedetta Ludovica Pettorini, Alessandro Narducci, Antonella de Carlo, Francesca Abet, Massimo Caldarelli, Luca Massimi, Gianpiero Tamburrini, Concezio Di Rocco

Published in: Child's Nervous System | Issue 5/2009

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Abstract

Objective

Surgical excision combined with radio-chemotherapy represents the gold standard of therapy of medulloblastoma. The effectiveness of such a combined treatment has encouraged the use of radiotherapy even in young paediatric patients, in spite of the many adverse effects reported in literature, and, in particular, the increased risk of a second radioinduced malignancy. Irradiation is the well-known risk factor for development of benign and malignant thyroid tumours. Children are more exposed to this risk because of their thyroid gland is more sensitive to carcinogenic effect of ionising radiation.

Case report

Two children underwent radiotherapy for the treatment of a medulloblastoma when they were 3 and 4 years old, respectively. At the age of 20 and 23, both of them underwent the surgical excision of a papillary thyroid carcinoma, 20 and 17 years after the radiotherapeutic treatment, respectively.

Conclusions

Radioinduced thyroid tumours are a well-recognised nosographic entities due to the particular sensitivity of this gland to ionising radiations. However, only a few papers on radioinduced thyroid neoplasms after CNS irradiation have been published in the literature. We report on two additional cases of thyroid neoplasms following childhood CNS irradiation for the treatment of a posterior fossa medulloblastoma.
Literature
1.
Acharya S, Sarafoglou K, LaQuaglia M, Lindsley S, Gerald W, Wolner N, Tan C, Sklar C (2003) Thyroid neoplasms after therapeutic irradiation for malignancies during childhood or adolescence. Cancer 97:2397–2403PubMedCrossRef
2.
Andrew DS, Kerr IF (1965) Carcinoma of thyroid following irradiation for medulloblastoma. Clin Radiol 16:282–283PubMedCrossRef
3.
Borejko J, Jeleniewska A (1978) Radiation induced thyroid carcinoma following treatment for fetal medulloblastoma. Pol Przegl Radiol Med Nukl 42:231–235PubMed
4.
Constine LS, Donaldson SS, McDougall IR, Cox RS, Link MP, Kaplan HS (1984) Thyroid dysfunction after radiotherapy in children with Hodgkin’s disease. Cancer 53:878–883PubMedCrossRef
5.
Corkill AG, Ross CF (1969) A case of neurofibromatosis complicated by medulloblastoma, neurogenic sarcoma, and radiation induced carcinoma of thyroid. J Neurol Neurosurg Psychiatry 32:43–47PubMedCrossRef
6.
de Vathaire F, Hardiman C, Shamsaldin A, Campbell S, Grimaud E, Hawkins M, Raquin M, Oberlin O, Diallo I, Zucker JM, Panis X, Lagrange JL, Daly-Schveitzer N, Lemerle J, Chavaudra J, Schlumberger M, Bonaiti C (1999) Thyroid carcinomas after irradiation for a first cancer during childhood. Arch Intern Med 159:2713–2719PubMedCrossRef
7.
Hancock SL, Cox RS, McDougall IR (1991) Thyroid diseases after treatment of Hodgkin’s disease. N Engl J Med 29:599–605CrossRef
8.
Knab B, Connell PP (2007) Radiotherapy for pediatric brain tumors: when and how. Expert Rev Anticancer Ther 7:69–77CrossRef
9.
Mazonakis M, Damilakis J, Varveris H, Fasoulaki M, Gourtsoyiannis N (2003) Risk estimation of radiation-induced thyroid cancer from treatment of brain tumors in adults and children. Int J Oncol 22:221–225PubMed
10.
Moysich KB, Menezes RJ, Michalek AM (2002) Chernobyl-related ionising radiation exposure and cancer risk: an epidemiological review. Lancet Oncol 3:269–79PubMedCrossRef
11.
Pettorini BL, Park YS, Caldarelli M, Massimi L, Tamburrini G, Di Rocco C (2008) Radiation-induced brain tumours after central nervous system irradiation in childhood: a review. Child’s Nerv Syst 24:793–805CrossRef
12.
Polkinghorn WR, Tarbell NJ (2007) Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification. Nat Clin Pract Oncol 4:295–304PubMedCrossRef
13.
Rabes HM, Demidchik EP, Sidorow JD, Lengfelder E, Beimfohr C, Hoelzel D, Klugbauer S (2000) Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. Clin Cancer Res 6:1093–1103PubMed
14.
Ricardi U, Corrias A, Einaudi S, Genitori L, Sandri A, Cordero di Montezemolo L, Besenzon L, Madon E, Urgesi A (2001) Thyroid disfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. Int J Radiation Oncol Biol Phys 50:1287–1294
15.
Roggli VL, Estrada R, Fechner RE (1979) Thyroid neoplasia following irradiation for medulloblastoma: report of two cases. Cancer 43:2232–2238PubMedCrossRef
16.
Ron E, Modan B, Preston D, Alfandary E, Stovall M, Boice JD Jr (1989) Thyroid neoplasia following low-dose radiation in childhood. Radiat Res 120:516–531PubMedCrossRef
17.
Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, Schneider AB, Tucker MA, Boice JD Jr (1995) Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 141:259–277PubMedCrossRef
18.
Roudebush CP, Asteris GT, DeGroot LJ (1978) Natural history of radiation-associated thyroid cancer. Arch Intern Med 138:1631–1634PubMedCrossRef
19.
Rubino C, Cailleux AF, Abbas M, Diallo I, Shamsaldin A, Caillou B, De Vathaire F, Schlumberger M (2002) Characteristics of follicular cell-derived thyroid carcinomas occurring after external radiation exposure: results of a case control study nested in a cohort. Thyroid 12:299–304PubMedCrossRef
20.
Samaan NA, Schultz PN, Hickey RC (1989) Medullary thyroid carcinoma: prognosis of familial versus nonfamilial disease and the role of radiotherapy. Horm Metab Res 21:21–25
21.
Sadetzki S, Chetrit A, Lubina A, Stovall M, Novikov I (2006) Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis. J Clin Endocrin Metab 91:4798–4804CrossRef
22.
Sandhu A, Constine LS, O’Mara RE, Hinkle A, Muhs AG, Woolf PD (2000) Subclinical thyroid disease after radiation therapy detected by radionuclide scanning. Int J Radiation Oncology Biol Phys 48:181–188CrossRef
23.
Sarne D, Schneider AB (1996) External radiation and thyroid neoplasia. Endocrinol Metab Clin North Am 25:181–195PubMedCrossRef
24.
Schneider AB, Shore-Freedman E, Ryo UY, Bekerman C, Favus M, Pinsky S (1985) Radiation induced tumors of the head and neck following childhood radiation: prospective studies. Medicine 64:1–15PubMedCrossRef
25.
Shalet SM, Rosenstock JD, Beardwell CG, Pearson D, Jones PH (1977) Thyroid dysfunction following external irradiation to the neck for Hodgkin’s disease in childhood. Clin Radiol 28:511–515PubMedCrossRef
26.
Shore RE (1992) Issues and epidemiological evidence regarding radiation-induced thyroid cancer. Radiat Res 131:98–111PubMedCrossRef
27.
Tucker MA, Jones PH, Boice JD Jr, Robison LL, Stone BJ, Stovall M, Jenkin RD, Lubin JH, Baum ES, Siegel SE (1991) Therapeutic radiation at a young age is linked to secondary thyroid cancer. Cancer Res 51:2885–2888PubMed
28.
Wood JW, Tamagaki H, Neriishi S, Sato T, Sheldon WF, Archer PG, Hamilton HB, Johnson KG (1969) Thyroid carcinoma in atomic bomb survivors, Hiroshima and Nagasaki. Am J Epidemiol 89:4–14PubMed
Metadata
Title
Thyroid neoplasm after central nervous system irradiation for medulloblastoma in childhood: report of two cases
Authors
Benedetta Ludovica Pettorini
Alessandro Narducci
Antonella de Carlo
Francesca Abet
Massimo Caldarelli
Luca Massimi
Gianpiero Tamburrini
Concezio Di Rocco
Publication date
01-05-2009
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 5/2009
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-009-0814-x

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