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Child's Nervous System
Published in: Child's Nervous System 7/2009

01-07-2009 | Invited Paper

The changing epidemiology of paediatric brain tumours: a review from the Hospital for Sick Children

Authors: Zul Kaderali, Maria Lamberti-Pasculli, James T. Rutka

Published in: Child's Nervous System | Issue 7/2009

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Abstract

Purpose

This study examines the changing epidemiology of paediatric brain tumours over the past three decades (1980–2008) in a single institution, SickKids, Toronto, Canada.

Methods

We classified 1,866 surgical pathology cases of brain tumours in children under the age of 19 according to the World Health Organization 2007 consensus and analysed them by gender, histological tumour type, age distribution and decade.

Results

Males showed a slightly higher predominance with 56.8% of cases overall. The main histological tumour types were low-grade (I/II) astrocytomas (26.4%), medulloblastoma (10.6%), anaplastic astrocytoma/glioblastoma multiforme (7.1%) and ependymoma (7.0%). Over three decades, an increasing proportion of certain tumour types, including pilocytic astroctoma, atypical teratoma/rhabdoid tumours and neuronal/mixed neuronal-glial tumours was seen.

Conclusions

Our results are consistent with those published with similar methodologies in other countries. Any changes in the epidemiology of childhood central nervous system tumours over the past three decades may be attributed in part to changing classification systems, improved imaging technologies and developments in epilepsy surgery; however, continued surveillance remains important.
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Metadata
Title
The changing epidemiology of paediatric brain tumours: a review from the Hospital for Sick Children
Authors
Zul Kaderali
Maria Lamberti-Pasculli
James T. Rutka
Publication date
01-07-2009
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 7/2009
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-008-0771-9

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