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Child's Nervous System
Published in: Child's Nervous System 10/2006

01-10-2006 | Original Paper

Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature

Authors: Manolo Piccirilli, Jacopo Lenzi, Catia Delfinis, Guido Trasimeni, Maurizio Salvati, Antonino Raco

Published in: Child's Nervous System | Issue 10/2006

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Abstract

Case reports

The authors report their experience about three children (two girls, one boy; average age 1.6 years) with a spontaneous regression of optic gliomas. All of them had a previous diagnosis of neurofibromatosis type 1 (NF 1). None of them underwent surgery or biopsy nor received chemotherapy or radiotherapy. The complete regression was documented by MRI scans performed during a mean follow-up of 6.3 years.

Literature review

Moreover, the authors analyze the features of the 16 cases previously reported in English literature of spontaneously regressed optic gliomas with an overview of the different therapeutic strategies. The knowledge that this kind of tumor, particularly in young patients, may regress is important in the decision of the best therapeutic approach.
Literature
1.
Martin P, Cushing H (1923) Primary gliomas of the chiasm and optic nerves in their intracranial portion. Arch Ophthalmol 52:209
2.
Hoffman HJ (1983) Optic pathway gliomas. In Amador L (ed) Brain tumors in the young. Charles C. Thomas, Springfield, IL, pp 622–633
3.
Matson DD (1969) Neurosurgery of infancy and childhood. Charles C. Thomas, Springfield, IL, pp 436–448
4.
McCullough DC, Johnson DL (1989) Optic nerve gliomas and other tumors involving the optic nerve and chiasm. In: McLaurin RL (ed) Pediatric neurosurgery. Saunders, Philadelphia, pp 391–397
5.
Sayers MP (1982) Optic nerve gliomas. In: McLaurin RL (ed) Pediatric neurosurgery. Grune & Stratton, New York, pp 513–522
6.
Hoffman HJ, Humphreys RP, Drake JM, et al (1993) Optic pathway/hypothalamic gliomas: a dilemma in management. Pediatr Neurosurg 19:186–195PubMedCrossRef
7.
Liu GT, Brodsky MC, Phillips PC, Belasco J, Janss A, Golden JC, Bilaniuk LL, Burson T, Duhaime AC, Sutton LN (2004) Optic radiation involvement in optic pathways gliomas in neurofibromatosis. Am J Ophthalmol 137:407–414PubMedCrossRef
8.
Menor F, Marti-Bonmati L, Arana E, Poyatos C, Cortina H (1998) Neurofibromatosis type one in children: MR imaging and follow-up studies of central nervous system findings. Eur J Radiol 26:121–131PubMedCrossRef
9.
Brzowski AE, Bazan C, Mumma JV, Ryan SG (1992) Spontaneous regression of optic glioma in a patient with neurofibromatosis. Neurology 42:679–680PubMed
10.
Gottschalk S, Tavkolian R, Buske A, Tinschert S, Lehmann R (1999) Spontaneous remission of chiasmatic/hypothalamic masses in neurofibromatosis type 1: report of two cases. Neuroradiology 91:199–201CrossRef
11.
Parazzini C, Triulzi F, Bianchini E, Agnetti V, Conti M, Zanolini C, Maninetti MM, Rossi LN, Scotti G (1995) Spontaneous involution of optic pathway lesions in neurofibromatosis type I: serial contrast MR evaluation. Am J Neuroradiol 16:1711–1718PubMed
12.
Parsa CF, Hoyt CS, Lesser RL, Weinstein JM, Strother CM, Muci-Mendoza R, Ramella M, Manor RS, Fletcher WA, Repka MX, Garrity JA, Ebner RN, Monteiro MLR, McFadzean RM, Rubtsova IV, Hoyt WF (2001) Spontaneous regression of optic gliomas. Arch Ophthalmol 119:516–529PubMed
13.
Perilongo G, Moras P, Carollo C, Battistella A, Clementi M, Laverda A, Murgia A (1999) Spontaneous partial regression of low grade glioma in children with neurofibromatosis-1: a real possibility. J Child Neurol 14:352–356PubMedCrossRef
14.
Shuper A, Horev G, Kornreich L, Michowiz S, Weitz R, Zaizov R, Cohen IJ (1997) Visual pathway glioma: an erratic tumour with therapeutic dilemmas. Arch Dis Child 76:259–263PubMedCrossRef
15.
Kovalic JJ, Grigsby PW, Shepard MJ, Fineberg BB, Thomas PR (1990) Radiation therapy for gliomas of the optic nerve and chiasm. Int J Radiat Oncol Biol Phys 18:927–932PubMed
16.
Weiss L, Sagerman RH, King GA, Chung CT, Dubowy RL (1987) Controversy in the management of optic nerve glioma. Cancer 59:1000–1004PubMedCrossRef
17.
Wong JY, Uhl V, Wara WM, Sheline GE (1987) Optic gliomas. A reanalysis of the University of California, San Francisco experience. Cancer 60:1847–1855PubMedCrossRef
18.
Epstein MA, Packer RJ, Rorke LB, Zimmerman RA, Goldwein JW, Sutton LN, Schut L (1992) Vascular malformation with radiation vasculopathy after treatment of chiasmatic/hypothalamic glioma. Cancer 70:887–893PubMedCrossRef
19.
Packer RJ, Savino PJ, Bilaniuk LT, Zimmerman RA, Schatz NJ, Rosenstock JG, Nelson DS, Jarrett PD, Bruce DA, Schut L (1983) Chiasmatic gliomas of childhood. A reappraisal of natural history and effectiveness of cranial irradiation. Childs Brain 10:393–403PubMedCrossRef
20.
Petronio J, Edwards MS, Prados M, Freyberger S, Rabbitt J, Silver P, Levin VA (1991) Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy. J Neurosurg 74:701–708PubMed
21.
Rosenstock JG, Packer RJ, Bilaniuk L, Bruce DA, Radcliffe JL, Savino P (1985) Chiasmatic optic glioma treated with chemotherapy. A preliminary report. J Neurosurg 63:862–866PubMedCrossRef
22.
Listernick R, Charrow J, Tomita T, Goldman S (1999) Carboplatin therapy for optic pathway tumors in children with neurofibromatosis type-1. J Neurooncology 45:185–190CrossRef
23.
Packer RJ, Lange B, Ater J, Nicholson S, Allen J, Walker R, Prados M, Jakacki R, Reaman G, Needles MN, Phillips PC, Ryan J, Boyett JM, Geyer R, Finlay J (1993) Carboplatin and vincristine for recurrent and newly diagnosed low grade gliomas of childhood. J Clin Oncol 11:850–856PubMed
24.
Moghrabi A, Friedman HS, Burger PC, Tien R, Oakes WJ (1993) Carboplatin treatment of progressive optic pathway gliomas to delay radiotherapy. J Neurosurg 79:223–227PubMedCrossRef
25.
Colosimo C, Cerase A, Giulio M (2000) Regression after biopsy of a pilocytic opticochiasmatic astrocytoma in a young adult without neurofibromatosis. Neuroradiology 42:352–356PubMedCrossRef
26.
Kernan JC, Horgan MA, Piatt JH, D’Agostino A (1998) Spontaneous involution of a diencephalic astrocytoma. Pediatr Neurosurg 29:149–153PubMedCrossRef
27.
Leisti EL, Pyhtinen J, Poyhonen M (1996) Spontaneous decrease of a pilocytic astrocytoma in neurofibromatosis type 1. Am J Neuroradiol 17:1691–1694PubMed
28.
Rubtsova IV, Parsa CF, Hoyt WF (1998) Spontaneous regression of familial glioma of the optic nerve in a boy with suspected neurofibromatosis 1 (Recklinghausen’s disease). Vestn Oftalmol 114(3):48–51PubMed
29.
Schmandt SM, Packer RJ, Vezina LG, Jane J (2000) Spontaneous regression of low grade astrocytomas in childhood. Pediatr Neurosurg 32:132–136PubMedCrossRef
30.
Takeuchi H, Kabuto M, Sato K, Kubota T (1997) Chiasmal gliomas with spontaneous regression: proliferation and apoptosis. Childs Nerv Syst 13:229–233CrossRef
31.
Guttman DH, Collins FS (1992) Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis. Ann Neurol 31:555CrossRef
32.
Basu TN, Gutmann DH, Fletcher JA (1992) Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis. Nature 356:713PubMedCrossRefADS
Metadata
Title
Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature
Authors
Manolo Piccirilli
Jacopo Lenzi
Catia Delfinis
Guido Trasimeni
Maurizio Salvati
Antonino Raco
Publication date
01-10-2006
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 10/2006
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-006-0061-3

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